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Dietary ganglioside reduces proinflammatory signaling in the intestine.

Miklavcic JJ, Schnabl KL, Mazurak VC, Thomson AB, Clandinin MT - J Nutr Metab (2012)

Bottom Line: Gangliosides are integral to the structure and function of cell membranes.Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside.Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside.

View Article: PubMed Central - PubMed

Affiliation: 4-002 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, Canada T6G 2R1.

ABSTRACT
Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling. Accelerated catabolism of ganglioside in intestinal disease results in increased proinflammatory signaling. Restoring proper structure and function to the diseased intestine can resolve inflammation, increase resistance to infection, and improve gut integrity to induce remission of conditions like necrotizing enterocolitis (NEC) and Crohn's disease (CD). Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside. Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside.

No MeSH data available.


Related in: MedlinePlus

Ganglioside catabolism. Enzyme responsible for catabolic processing step is shown adjacent to arrow. Adapted from Devlin [11].
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fig2: Ganglioside catabolism. Enzyme responsible for catabolic processing step is shown adjacent to arrow. Adapted from Devlin [11].

Mentions: In mammalian cells, ganglioside synthesis commences with ceramide synthesis in the endoplasmic reticulum [7, 8]. Ceramide is transported to the cytosolic Golgi face for addition of glucose [9]. From this point, sugar moieties and sialic acids are added to form one of several gangliosides. These reactions are accomplished by sialyltransferases, galactosaminyltransferases, and galactosyltransferases on the luminal face of the Golgi complex at controlled rates [10]. Ganglioside catabolism is outlined in Figure 2.


Dietary ganglioside reduces proinflammatory signaling in the intestine.

Miklavcic JJ, Schnabl KL, Mazurak VC, Thomson AB, Clandinin MT - J Nutr Metab (2012)

Ganglioside catabolism. Enzyme responsible for catabolic processing step is shown adjacent to arrow. Adapted from Devlin [11].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3306953&req=5

fig2: Ganglioside catabolism. Enzyme responsible for catabolic processing step is shown adjacent to arrow. Adapted from Devlin [11].
Mentions: In mammalian cells, ganglioside synthesis commences with ceramide synthesis in the endoplasmic reticulum [7, 8]. Ceramide is transported to the cytosolic Golgi face for addition of glucose [9]. From this point, sugar moieties and sialic acids are added to form one of several gangliosides. These reactions are accomplished by sialyltransferases, galactosaminyltransferases, and galactosyltransferases on the luminal face of the Golgi complex at controlled rates [10]. Ganglioside catabolism is outlined in Figure 2.

Bottom Line: Gangliosides are integral to the structure and function of cell membranes.Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside.Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside.

View Article: PubMed Central - PubMed

Affiliation: 4-002 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, Canada T6G 2R1.

ABSTRACT
Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division, differentiation, and signaling. Accelerated catabolism of ganglioside in intestinal disease results in increased proinflammatory signaling. Restoring proper structure and function to the diseased intestine can resolve inflammation, increase resistance to infection, and improve gut integrity to induce remission of conditions like necrotizing enterocolitis (NEC) and Crohn's disease (CD). Maintaining inactive state of disease may be achieved by reducing the rate that gangliosides are degraded or by increasing intake of dietary ganglioside. Collectively, the studies outlined in this paper indicate that the amount of gangliosides GM3 and GD3 in intestinal mucosa is decreased with inflammation, low level of GM3 is associated with higher production of proinflammatory signals, and ganglioside content of intestinal mucosa can be increased by dietary ganglioside.

No MeSH data available.


Related in: MedlinePlus