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Epidemiology, clinical manifestations, and long-term outcomes of a major outbreak of chikungunya in a hamlet in sri lanka, in 2007: a longitudinal cohort study.

Kularatne SA, Weerasinghe SC, Gihan C, Wickramasinghe S, Dharmarathne S, Abeyrathna A, Jayalath T - J Trop Med (2012)

Bottom Line: Of the CAD patients, 102 (44%) had recovered in 141 days (range 30-210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively.Carpal tunnel syndrome (CTS) manifested in 110 (21%).Females showed preponderance for complications over males: acute arthritis 147 versus 86, P = 0.001; CAD 136 versus 84, P = 0.029; CTS 88 versus 22, P = 0.001; relapses 105 versus 68, P = 0.001.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.

ABSTRACT
Chikungunya outbreaks occurred in the central province, Sri Lanka in 2006. This community-based study reports the epidemiology and the natural history of the infection from an affected village. Of the 199 families and 1001 individuals in the village, 159 (80%) and 513 (51%) were affected, respectively, comprising 237 (46%) males with peak incidence at 40-50 years. The acute illness caused polyarthritis in 233 (46%), and of them 230 (98%) progressed to chronic arthritic disability (CAD). Of the CAD patients, 102 (44%) had recovered in 141 days (range 30-210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively. Carpal tunnel syndrome (CTS) manifested in 110 (21%). Females showed preponderance for complications over males: acute arthritis 147 versus 86, P = 0.001; CAD 136 versus 84, P = 0.029; CTS 88 versus 22, P = 0.001; relapses 105 versus 68, P = 0.001. Chikungunya was highly communicable and caused lasting crippling complications.

No MeSH data available.


Related in: MedlinePlus

Number of individuals with chronic arthritic disability (CAD) at followup.
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fig3: Number of individuals with chronic arthritic disability (CAD) at followup.

Mentions: The proportion with CTS had increased with the age. In the age group of 0–12 years, there were no reported cases of CTS whilst the incidence increased with age: in 13–22-year group 5%, 33–42-year group 31%, 43–52-year group 37%, and 53–62-year group 36%. Furthermore, the incidence of CTS had significantly increased in females, in patients with past history of arthritis and in the chronic arthritic disability group. Subjects with CAD were followed up at 6, 12, 24, and 36 months following the acute clinical illness. The numbers with the CAD are as follows: 230 (100%), 41 (17.8%), 22 (9.5%), and 14 (6.1%), respectively (Figure 3).


Epidemiology, clinical manifestations, and long-term outcomes of a major outbreak of chikungunya in a hamlet in sri lanka, in 2007: a longitudinal cohort study.

Kularatne SA, Weerasinghe SC, Gihan C, Wickramasinghe S, Dharmarathne S, Abeyrathna A, Jayalath T - J Trop Med (2012)

Number of individuals with chronic arthritic disability (CAD) at followup.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3306924&req=5

fig3: Number of individuals with chronic arthritic disability (CAD) at followup.
Mentions: The proportion with CTS had increased with the age. In the age group of 0–12 years, there were no reported cases of CTS whilst the incidence increased with age: in 13–22-year group 5%, 33–42-year group 31%, 43–52-year group 37%, and 53–62-year group 36%. Furthermore, the incidence of CTS had significantly increased in females, in patients with past history of arthritis and in the chronic arthritic disability group. Subjects with CAD were followed up at 6, 12, 24, and 36 months following the acute clinical illness. The numbers with the CAD are as follows: 230 (100%), 41 (17.8%), 22 (9.5%), and 14 (6.1%), respectively (Figure 3).

Bottom Line: Of the CAD patients, 102 (44%) had recovered in 141 days (range 30-210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively.Carpal tunnel syndrome (CTS) manifested in 110 (21%).Females showed preponderance for complications over males: acute arthritis 147 versus 86, P = 0.001; CAD 136 versus 84, P = 0.029; CTS 88 versus 22, P = 0.001; relapses 105 versus 68, P = 0.001.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.

ABSTRACT
Chikungunya outbreaks occurred in the central province, Sri Lanka in 2006. This community-based study reports the epidemiology and the natural history of the infection from an affected village. Of the 199 families and 1001 individuals in the village, 159 (80%) and 513 (51%) were affected, respectively, comprising 237 (46%) males with peak incidence at 40-50 years. The acute illness caused polyarthritis in 233 (46%), and of them 230 (98%) progressed to chronic arthritic disability (CAD). Of the CAD patients, 102 (44%) had recovered in 141 days (range 30-210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively. Carpal tunnel syndrome (CTS) manifested in 110 (21%). Females showed preponderance for complications over males: acute arthritis 147 versus 86, P = 0.001; CAD 136 versus 84, P = 0.029; CTS 88 versus 22, P = 0.001; relapses 105 versus 68, P = 0.001. Chikungunya was highly communicable and caused lasting crippling complications.

No MeSH data available.


Related in: MedlinePlus