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Direction-sensitive codes for observed head turns in human superior temporal sulcus.

Carlin JD, Rowe JB, Kriegeskorte N, Thompson R, Calder AJ - Cereb. Cortex (2011)

Bottom Line: Research in macaque neurophysiology suggests that anterior superior temporal sulcus (STS) contains a direction-sensitive code for such social attention cues.Such head turn discrimination was observed in right anterior STS/superior temporal gyrus (STG).Response patterns in this region were also significantly more discriminable for head turn direction than for rotation direction in physically matched ellipsoid control stimuli.

View Article: PubMed Central - PubMed

Affiliation: Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK. johan.carlin@mrc-cbu.cam.ac.uk

ABSTRACT
Humans and other primates are adept at using the direction of another's gaze or head turn to infer where that individual is attending. Research in macaque neurophysiology suggests that anterior superior temporal sulcus (STS) contains a direction-sensitive code for such social attention cues. By contrast, most human functional Magnetic resonance imaging (fMRI) studies report that posterior STS is responsive to social attention cues. It is unclear whether this functional discrepancy is caused by a species difference or by experimental design differences. Furthermore, social attention cues are dynamic in naturalistic social interaction, but most studies to date have been restricted to static displays. In order to address these issues, we used multivariate pattern analysis of fMRI data to test whether response patterns in human right STS distinguish between leftward and rightward dynamic head turns. Such head turn discrimination was observed in right anterior STS/superior temporal gyrus (STG). Response patterns in this region were also significantly more discriminable for head turn direction than for rotation direction in physically matched ellipsoid control stimuli. Our findings suggest a role for right anterior STS/STG in coding the direction of motion in dynamic social attention cues.

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Group results for the univariate analysis, displayed on the mean T1 volume for the sample. Effects are displayed corrected for multiple comparisons within the right STS region (panels A–B; hypothesis-driven analysis, P < 0.05 FWE) or the full gray matter volume (panels C–D; exploratory analysis, P < 0.05 FWE). The highlighted portion of each panel shows the extent of the mask. (A) Greater univariate responses to heads than to ellipsoids in the right STS region. (B) Greater univariate responses to ellipsoids than to heads in the right STS region. (C) Gray matter regions with greater univariate responses to left than to right head turns (warm colors) or with greater univariate responses to right than to left head turns (cool colors). The effects do not overlap at any site. (D) Gray matter regions with greater univariate responses to heads than to ellipsoids.
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fig4: Group results for the univariate analysis, displayed on the mean T1 volume for the sample. Effects are displayed corrected for multiple comparisons within the right STS region (panels A–B; hypothesis-driven analysis, P < 0.05 FWE) or the full gray matter volume (panels C–D; exploratory analysis, P < 0.05 FWE). The highlighted portion of each panel shows the extent of the mask. (A) Greater univariate responses to heads than to ellipsoids in the right STS region. (B) Greater univariate responses to ellipsoids than to heads in the right STS region. (C) Gray matter regions with greater univariate responses to left than to right head turns (warm colors) or with greater univariate responses to right than to left head turns (cool colors). The effects do not overlap at any site. (D) Gray matter regions with greater univariate responses to heads than to ellipsoids.

Mentions: Collapsing across motion direction, right posterior STS responded significantly more to heads than to ellipsoids (P < 0.002 FWE, 48 −44 16 mm MNI, Fig. 4A), while a region in middle STG bordering on the edge of the ROI responded more to ellipsoids than to heads (P = 0.004 FWE, 60 0 0 mm MNI, Fig. 4B). Thus, univariate selectivity for heads over ellipsoids occurred in posterior STS, 57 mm from the left–right head turn classification peak in anterior STS/STG. The peaks for univariate selectivity for ellipsoids over heads and for left–right ellipsoid rotation classification were separated by 20 mm. Neither of the univariate effects overlapped with the classification effects.


Direction-sensitive codes for observed head turns in human superior temporal sulcus.

Carlin JD, Rowe JB, Kriegeskorte N, Thompson R, Calder AJ - Cereb. Cortex (2011)

Group results for the univariate analysis, displayed on the mean T1 volume for the sample. Effects are displayed corrected for multiple comparisons within the right STS region (panels A–B; hypothesis-driven analysis, P < 0.05 FWE) or the full gray matter volume (panels C–D; exploratory analysis, P < 0.05 FWE). The highlighted portion of each panel shows the extent of the mask. (A) Greater univariate responses to heads than to ellipsoids in the right STS region. (B) Greater univariate responses to ellipsoids than to heads in the right STS region. (C) Gray matter regions with greater univariate responses to left than to right head turns (warm colors) or with greater univariate responses to right than to left head turns (cool colors). The effects do not overlap at any site. (D) Gray matter regions with greater univariate responses to heads than to ellipsoids.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3306570&req=5

fig4: Group results for the univariate analysis, displayed on the mean T1 volume for the sample. Effects are displayed corrected for multiple comparisons within the right STS region (panels A–B; hypothesis-driven analysis, P < 0.05 FWE) or the full gray matter volume (panels C–D; exploratory analysis, P < 0.05 FWE). The highlighted portion of each panel shows the extent of the mask. (A) Greater univariate responses to heads than to ellipsoids in the right STS region. (B) Greater univariate responses to ellipsoids than to heads in the right STS region. (C) Gray matter regions with greater univariate responses to left than to right head turns (warm colors) or with greater univariate responses to right than to left head turns (cool colors). The effects do not overlap at any site. (D) Gray matter regions with greater univariate responses to heads than to ellipsoids.
Mentions: Collapsing across motion direction, right posterior STS responded significantly more to heads than to ellipsoids (P < 0.002 FWE, 48 −44 16 mm MNI, Fig. 4A), while a region in middle STG bordering on the edge of the ROI responded more to ellipsoids than to heads (P = 0.004 FWE, 60 0 0 mm MNI, Fig. 4B). Thus, univariate selectivity for heads over ellipsoids occurred in posterior STS, 57 mm from the left–right head turn classification peak in anterior STS/STG. The peaks for univariate selectivity for ellipsoids over heads and for left–right ellipsoid rotation classification were separated by 20 mm. Neither of the univariate effects overlapped with the classification effects.

Bottom Line: Research in macaque neurophysiology suggests that anterior superior temporal sulcus (STS) contains a direction-sensitive code for such social attention cues.Such head turn discrimination was observed in right anterior STS/superior temporal gyrus (STG).Response patterns in this region were also significantly more discriminable for head turn direction than for rotation direction in physically matched ellipsoid control stimuli.

View Article: PubMed Central - PubMed

Affiliation: Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK. johan.carlin@mrc-cbu.cam.ac.uk

ABSTRACT
Humans and other primates are adept at using the direction of another's gaze or head turn to infer where that individual is attending. Research in macaque neurophysiology suggests that anterior superior temporal sulcus (STS) contains a direction-sensitive code for such social attention cues. By contrast, most human functional Magnetic resonance imaging (fMRI) studies report that posterior STS is responsive to social attention cues. It is unclear whether this functional discrepancy is caused by a species difference or by experimental design differences. Furthermore, social attention cues are dynamic in naturalistic social interaction, but most studies to date have been restricted to static displays. In order to address these issues, we used multivariate pattern analysis of fMRI data to test whether response patterns in human right STS distinguish between leftward and rightward dynamic head turns. Such head turn discrimination was observed in right anterior STS/superior temporal gyrus (STG). Response patterns in this region were also significantly more discriminable for head turn direction than for rotation direction in physically matched ellipsoid control stimuli. Our findings suggest a role for right anterior STS/STG in coding the direction of motion in dynamic social attention cues.

Show MeSH