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Short-term Outcomes of Collagen Crosslinking for Early Keratoconus.

Derakhshan A, Shandiz JH, Ahadi M, Daneshvar R, Esmaily H - J Ophthalmic Vis Res (2011)

Bottom Line: Postoperatively, UCVA increased by 2 Snellen lines and BSCVA was improved by 1.7 Snellen lines (P < 0.001).Spherical equivalent refractive error was reduced by 0.55 D, and maximum and mean K values were decreased by 0.65 D and 0.51 D respectively (P < 0.05 for all comparisons).Evidence of regression was present in 71% of treated eyes.

View Article: PubMed Central - PubMed

Affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT

Purpose: To assess the efficacy of collagen crosslinking with riboflavin and ultraviolet A (UVA) radiation for treatment of early keratoconus.

Methods: Thirty-one eyes of 22 patients with early keratoconus were included in this study. All patients underwent slit lamp examination and assessment of uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), intraocular pressure, corneal topography and pachymetry. Collagen crosslinking was performed without epithelial removal. Riboflavin was applied to the cornea every 3 minutes 30 minutes before UVA irradiation and every 5 minutes thereafter. Patients were re-assessed 1, 3, and 6 months after treatment.

Results: Postoperatively, UCVA increased by 2 Snellen lines and BSCVA was improved by 1.7 Snellen lines (P < 0.001). Spherical equivalent refractive error was reduced by 0.55 D, and maximum and mean K values were decreased by 0.65 D and 0.51 D respectively (P < 0.05 for all comparisons). Evidence of regression was present in 71% of treated eyes.

Conclusion: Collagen crosslinking demonstrated significant improvement in vision with reduction in corneal power and spherical equivalent refractive error in eyes with early keratoconus.

No MeSH data available.


Related in: MedlinePlus

Changes in refraction (diopters).SE, spherical equivalent
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f2-jovr-6-3-155: Changes in refraction (diopters).SE, spherical equivalent

Mentions: Mean spherical equivalent refractive error was −5.13 ± 3.67 D preoperatively and −4.58 ± 3.27 D postoperatively (Fig. 2). Mean reduction in spherical equivalent was 0.55 ± 0.92 D (P = 0.004) over the follow-up period in 22 eyes (71%).


Short-term Outcomes of Collagen Crosslinking for Early Keratoconus.

Derakhshan A, Shandiz JH, Ahadi M, Daneshvar R, Esmaily H - J Ophthalmic Vis Res (2011)

Changes in refraction (diopters).SE, spherical equivalent
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3306103&req=5

f2-jovr-6-3-155: Changes in refraction (diopters).SE, spherical equivalent
Mentions: Mean spherical equivalent refractive error was −5.13 ± 3.67 D preoperatively and −4.58 ± 3.27 D postoperatively (Fig. 2). Mean reduction in spherical equivalent was 0.55 ± 0.92 D (P = 0.004) over the follow-up period in 22 eyes (71%).

Bottom Line: Postoperatively, UCVA increased by 2 Snellen lines and BSCVA was improved by 1.7 Snellen lines (P < 0.001).Spherical equivalent refractive error was reduced by 0.55 D, and maximum and mean K values were decreased by 0.65 D and 0.51 D respectively (P < 0.05 for all comparisons).Evidence of regression was present in 71% of treated eyes.

View Article: PubMed Central - PubMed

Affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.

ABSTRACT

Purpose: To assess the efficacy of collagen crosslinking with riboflavin and ultraviolet A (UVA) radiation for treatment of early keratoconus.

Methods: Thirty-one eyes of 22 patients with early keratoconus were included in this study. All patients underwent slit lamp examination and assessment of uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), intraocular pressure, corneal topography and pachymetry. Collagen crosslinking was performed without epithelial removal. Riboflavin was applied to the cornea every 3 minutes 30 minutes before UVA irradiation and every 5 minutes thereafter. Patients were re-assessed 1, 3, and 6 months after treatment.

Results: Postoperatively, UCVA increased by 2 Snellen lines and BSCVA was improved by 1.7 Snellen lines (P < 0.001). Spherical equivalent refractive error was reduced by 0.55 D, and maximum and mean K values were decreased by 0.65 D and 0.51 D respectively (P < 0.05 for all comparisons). Evidence of regression was present in 71% of treated eyes.

Conclusion: Collagen crosslinking demonstrated significant improvement in vision with reduction in corneal power and spherical equivalent refractive error in eyes with early keratoconus.

No MeSH data available.


Related in: MedlinePlus