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Immunologic corneal graft rejection after administration of topical latanoprost: a report of two patients.

Nouri-Mahdavi K, Javadi MA, Jafarinasab MR - J Ophthalmic Vis Res (2011)

Bottom Line: To report endothelial corneal graft rejection after administration of topical latanoprost eye drops.Cystoid macular edema developed simultaneously in one patient.Latanoprost may trigger endothelial graft rejection in susceptible eyes.

View Article: PubMed Central - PubMed

Affiliation: Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.

ABSTRACT

Purpose: To report endothelial corneal graft rejection after administration of topical latanoprost eye drops.

Case report: Two eyes of two patients with a history of multiple intraocular procedures prior to penetrating keratoplasty developed endothelial graft rejection one month after administration of topical latanoprost. Cystoid macular edema developed simultaneously in one patient.

Conclusion: Latanoprost may trigger endothelial graft rejection in susceptible eyes.

No MeSH data available.


Related in: MedlinePlus

Immunologic graft rejection one month after starting latanoprost in case 1. The larger arrow shows the border between the clear and edematous areas of the graft. The small arrow points to inferior keratic precipitates.
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f1-jovr-6-2-127: Immunologic graft rejection one month after starting latanoprost in case 1. The larger arrow shows the border between the clear and edematous areas of the graft. The small arrow points to inferior keratic precipitates.

Mentions: A 68-year-old woman underwent PKP a few months after complicated cataract surgery in the right eye in 1995. She had a second PKP in the same eye in June 2000. After intraocular pressure (IOP) became uncontrolled, latanoprost was added to her prescription of timolol. Two weeks later, best-corrected visual acuity (BCVA) was 20/400, slit-lamp examination revealed a clear, avascular graft and a quiet eye, IOP was 57 mmHg. A polymethyl methacrylate (PMMA) intraocular lens was observed, centered over an open posterior capsule. Vitreous incarceration in the cataract incision was present superonasally along with extensive iridocorneal adhesions. The optic disc seemed mildly saucerized. Moderate pigmentary changes were evident in the macula. After adding acetazolamide, IOP was reduced to 16 mmHg. Topical dorzolamide was substituted for acetazolamide with maintenance of IOP control. Two weeks later, the patient returned with a decrease in BCVA to counting fingers at 1 m having mistakenly used latanoprost four times daily. Tonometry revealed IOP of 10 mmHg. Sectoral corneal edema, multiple white keratic precipitates, and mild anterior chamber reaction were observed (Figure 1). Cystoid macular edema was suspected after fundus examination. Latanoprost was immediately discontinued and graft rejection was treated with corticosteroids. Fluorescein angiography was performed the next day and confirmed the presence of CME. The rejection episode gradually improved over the next few weeks together with resolution of corneal edema, inflammatory signs and CME while BCVA improved to 20/400.


Immunologic corneal graft rejection after administration of topical latanoprost: a report of two patients.

Nouri-Mahdavi K, Javadi MA, Jafarinasab MR - J Ophthalmic Vis Res (2011)

Immunologic graft rejection one month after starting latanoprost in case 1. The larger arrow shows the border between the clear and edematous areas of the graft. The small arrow points to inferior keratic precipitates.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3306091&req=5

f1-jovr-6-2-127: Immunologic graft rejection one month after starting latanoprost in case 1. The larger arrow shows the border between the clear and edematous areas of the graft. The small arrow points to inferior keratic precipitates.
Mentions: A 68-year-old woman underwent PKP a few months after complicated cataract surgery in the right eye in 1995. She had a second PKP in the same eye in June 2000. After intraocular pressure (IOP) became uncontrolled, latanoprost was added to her prescription of timolol. Two weeks later, best-corrected visual acuity (BCVA) was 20/400, slit-lamp examination revealed a clear, avascular graft and a quiet eye, IOP was 57 mmHg. A polymethyl methacrylate (PMMA) intraocular lens was observed, centered over an open posterior capsule. Vitreous incarceration in the cataract incision was present superonasally along with extensive iridocorneal adhesions. The optic disc seemed mildly saucerized. Moderate pigmentary changes were evident in the macula. After adding acetazolamide, IOP was reduced to 16 mmHg. Topical dorzolamide was substituted for acetazolamide with maintenance of IOP control. Two weeks later, the patient returned with a decrease in BCVA to counting fingers at 1 m having mistakenly used latanoprost four times daily. Tonometry revealed IOP of 10 mmHg. Sectoral corneal edema, multiple white keratic precipitates, and mild anterior chamber reaction were observed (Figure 1). Cystoid macular edema was suspected after fundus examination. Latanoprost was immediately discontinued and graft rejection was treated with corticosteroids. Fluorescein angiography was performed the next day and confirmed the presence of CME. The rejection episode gradually improved over the next few weeks together with resolution of corneal edema, inflammatory signs and CME while BCVA improved to 20/400.

Bottom Line: To report endothelial corneal graft rejection after administration of topical latanoprost eye drops.Cystoid macular edema developed simultaneously in one patient.Latanoprost may trigger endothelial graft rejection in susceptible eyes.

View Article: PubMed Central - PubMed

Affiliation: Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA.

ABSTRACT

Purpose: To report endothelial corneal graft rejection after administration of topical latanoprost eye drops.

Case report: Two eyes of two patients with a history of multiple intraocular procedures prior to penetrating keratoplasty developed endothelial graft rejection one month after administration of topical latanoprost. Cystoid macular edema developed simultaneously in one patient.

Conclusion: Latanoprost may trigger endothelial graft rejection in susceptible eyes.

No MeSH data available.


Related in: MedlinePlus