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Acid-base disorders in patients with chronic obstructive pulmonary disease: a pathophysiological review.

Bruno CM, Valenti M - J. Biomed. Biotechnol. (2012)

Bottom Line: The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate.Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis.Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine and Systemic Diseases, University of Catania, 95100 Catania, Italy. cmbruno@unict.it

ABSTRACT
The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate. Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis. Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided.

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Related in: MedlinePlus

Relationship between pCO2 and bicarbonate in acute and chronic respiratory acidosis.
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Related In: Results  -  Collection


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fig5: Relationship between pCO2 and bicarbonate in acute and chronic respiratory acidosis.

Mentions: In the last example, the variation in pH value is significantly smaller than in the previous one (0.11 versus 0.23 units). This explains why chronic respiratory acidosis is generally less severe and better tolerated than acute with similar hypercapnia. Figure 5 shows the different slope of the relationship between pCO2 and bicarbonate in acute and chronic respiratory acidosis.


Acid-base disorders in patients with chronic obstructive pulmonary disease: a pathophysiological review.

Bruno CM, Valenti M - J. Biomed. Biotechnol. (2012)

Relationship between pCO2 and bicarbonate in acute and chronic respiratory acidosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303884&req=5

fig5: Relationship between pCO2 and bicarbonate in acute and chronic respiratory acidosis.
Mentions: In the last example, the variation in pH value is significantly smaller than in the previous one (0.11 versus 0.23 units). This explains why chronic respiratory acidosis is generally less severe and better tolerated than acute with similar hypercapnia. Figure 5 shows the different slope of the relationship between pCO2 and bicarbonate in acute and chronic respiratory acidosis.

Bottom Line: The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate.Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis.Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine and Systemic Diseases, University of Catania, 95100 Catania, Italy. cmbruno@unict.it

ABSTRACT
The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate. Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis. Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided.

Show MeSH
Related in: MedlinePlus