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Coincidence of HPV11-Positive Urethral Condyloma Acuminatum and HPV-Negative Multiple Bladder Papillomas in a Female.

Nakazaki N, Zaitsu M, Mikami K, Yui S, Kanatani A, Nakatani T, Ito A, Takeshima Y, Tonooka A, Oka H, Miki T, Takeuchi T - Case Rep Med (2012)

Bottom Line: Human papillomaviruses (HPVs) are associated with proliferative lesions in a variety of human epithelial types.Four of the bladder tumors were diagnosed as squamous papilloma, and the other was urothelial inverted papilloma.Postoperative course was uneventful.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki 211-8510, Japan.

ABSTRACT
Human papillomaviruses (HPVs) are associated with proliferative lesions in a variety of human epithelial types. A 38-year-old female presented with a diagnosis of urethral condyloma acuminatum. She underwent transurethral resection of the urethral condyloma. At that time, multiple (five) bladder tumors were simultaneously found and also removed by transurethral resection. Four of the bladder tumors were diagnosed as squamous papilloma, and the other was urothelial inverted papilloma. Postoperative course was uneventful. Genomic DNA was extracted from 10 μm thick sections of each bladder tumor as well as urethral condyloma. Then, 16 types of HPV DNA sequences were assessed with the PapiPlex method using genomic DNA samples extracted from each bladder tumor as well as urethral condyloma. HPV-11 was detected in DNA extracted from the urethral condyloma, while no HPV DNA sequences were positive in any of the genomic DNA samples extracted from the bladder tumors.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and eosin staining of bladder urothelial inverted papilloma (HPV negative).
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fig3: Hematoxylin and eosin staining of bladder urothelial inverted papilloma (HPV negative).

Mentions: A 38-year-old female presented with a diagnosis of urethral condyloma acuminatum. There were no condylomatous lesions in the gynecological area. She underwent transurethral resection of the urethral condyloma. At that time, multiple (five) bladder tumors of less than 1 cm in diameter were simultaneously found and also removed by transurethral resection. Tissues were fixed in 10% formalin, then embedded in paraffin. Sections were stained with hematoxylin and eosin (HE). Four of the bladder tumors were diagnosed as squamous papilloma (Figure 2), and the other was urothelial inverted papilloma (Figure 3) by HE staining. Histology of the urethral lesions showed koilocytosis and parakeratosis supporting the diagnosis as condyloma acuminatum (Figure 1). Post-operative course was uneventful.


Coincidence of HPV11-Positive Urethral Condyloma Acuminatum and HPV-Negative Multiple Bladder Papillomas in a Female.

Nakazaki N, Zaitsu M, Mikami K, Yui S, Kanatani A, Nakatani T, Ito A, Takeshima Y, Tonooka A, Oka H, Miki T, Takeuchi T - Case Rep Med (2012)

Hematoxylin and eosin staining of bladder urothelial inverted papilloma (HPV negative).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303756&req=5

fig3: Hematoxylin and eosin staining of bladder urothelial inverted papilloma (HPV negative).
Mentions: A 38-year-old female presented with a diagnosis of urethral condyloma acuminatum. There were no condylomatous lesions in the gynecological area. She underwent transurethral resection of the urethral condyloma. At that time, multiple (five) bladder tumors of less than 1 cm in diameter were simultaneously found and also removed by transurethral resection. Tissues were fixed in 10% formalin, then embedded in paraffin. Sections were stained with hematoxylin and eosin (HE). Four of the bladder tumors were diagnosed as squamous papilloma (Figure 2), and the other was urothelial inverted papilloma (Figure 3) by HE staining. Histology of the urethral lesions showed koilocytosis and parakeratosis supporting the diagnosis as condyloma acuminatum (Figure 1). Post-operative course was uneventful.

Bottom Line: Human papillomaviruses (HPVs) are associated with proliferative lesions in a variety of human epithelial types.Four of the bladder tumors were diagnosed as squamous papilloma, and the other was urothelial inverted papilloma.Postoperative course was uneventful.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki 211-8510, Japan.

ABSTRACT
Human papillomaviruses (HPVs) are associated with proliferative lesions in a variety of human epithelial types. A 38-year-old female presented with a diagnosis of urethral condyloma acuminatum. She underwent transurethral resection of the urethral condyloma. At that time, multiple (five) bladder tumors were simultaneously found and also removed by transurethral resection. Four of the bladder tumors were diagnosed as squamous papilloma, and the other was urothelial inverted papilloma. Postoperative course was uneventful. Genomic DNA was extracted from 10 μm thick sections of each bladder tumor as well as urethral condyloma. Then, 16 types of HPV DNA sequences were assessed with the PapiPlex method using genomic DNA samples extracted from each bladder tumor as well as urethral condyloma. HPV-11 was detected in DNA extracted from the urethral condyloma, while no HPV DNA sequences were positive in any of the genomic DNA samples extracted from the bladder tumors.

No MeSH data available.


Related in: MedlinePlus