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An experimental model for resistance exercise in rodents.

Nicastro H, Zanchi NE, da Luz CR, Chaves DF, Lancha AH - J. Biomed. Biotechnol. (2012)

Bottom Line: We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal.With this system, it is not necessary to impose fasting or electric shock for the animal to perform the task proposed (muscle contraction).Therefore, despite experimental limitations, we believe that this RE apparatus is closer to the physiological context observed in humans.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, Cidade Universitária, São Paulo, SP, Brazil. nicastro@usp.br

ABSTRACT
This study aimed to develop an equipment and system of resistance exercise (RE), based on squat-type exercise for rodents, with control of training variables. We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal. With this system, it is not necessary to impose fasting or electric shock for the animal to perform the task proposed (muscle contraction). Furthermore, it is possible to perform muscle function tests in vivo within the context of the exercise proposed and control variables such as intensity, volume (sets and repetitions), and exercise session length, rest interval between sets and repetitions, and concentric strength. Based on the experiments conducted, we demonstrated that the model proposed is able to perform more specific control of other RE variables, especially rest interval between sets and repetitions, and encourages the animal to exercise through short-term energy restriction and "disturbing" stimulus that do not promote alterations in body weight. Therefore, despite experimental limitations, we believe that this RE apparatus is closer to the physiological context observed in humans.

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Related in: MedlinePlus

Body weight before (Pre) and at the end (Post) of the adaptation phases. Not significantly different (P > 0.05).
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fig3: Body weight before (Pre) and at the end (Post) of the adaptation phases. Not significantly different (P > 0.05).

Mentions: As previously described, to condition the animal to the experimental model it was necessary to carry out periods of energy restriction on the previous day of nose-poke 1 and 2 and standing 1 phases. However, as shown in Figure 3, energy restriction did not promote significant changes in body weight at the end of the conditioning process (414.1 ± 4.8 g in Pre versus 410.8 ± 4.2 g in Post period; P > 0.05).


An experimental model for resistance exercise in rodents.

Nicastro H, Zanchi NE, da Luz CR, Chaves DF, Lancha AH - J. Biomed. Biotechnol. (2012)

Body weight before (Pre) and at the end (Post) of the adaptation phases. Not significantly different (P > 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303681&req=5

fig3: Body weight before (Pre) and at the end (Post) of the adaptation phases. Not significantly different (P > 0.05).
Mentions: As previously described, to condition the animal to the experimental model it was necessary to carry out periods of energy restriction on the previous day of nose-poke 1 and 2 and standing 1 phases. However, as shown in Figure 3, energy restriction did not promote significant changes in body weight at the end of the conditioning process (414.1 ± 4.8 g in Pre versus 410.8 ± 4.2 g in Post period; P > 0.05).

Bottom Line: We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal.With this system, it is not necessary to impose fasting or electric shock for the animal to perform the task proposed (muscle contraction).Therefore, despite experimental limitations, we believe that this RE apparatus is closer to the physiological context observed in humans.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, Cidade Universitária, São Paulo, SP, Brazil. nicastro@usp.br

ABSTRACT
This study aimed to develop an equipment and system of resistance exercise (RE), based on squat-type exercise for rodents, with control of training variables. We developed an operant conditioning system composed of sound, light and feeding devices that allowed optimized RE performance by the animal. With this system, it is not necessary to impose fasting or electric shock for the animal to perform the task proposed (muscle contraction). Furthermore, it is possible to perform muscle function tests in vivo within the context of the exercise proposed and control variables such as intensity, volume (sets and repetitions), and exercise session length, rest interval between sets and repetitions, and concentric strength. Based on the experiments conducted, we demonstrated that the model proposed is able to perform more specific control of other RE variables, especially rest interval between sets and repetitions, and encourages the animal to exercise through short-term energy restriction and "disturbing" stimulus that do not promote alterations in body weight. Therefore, despite experimental limitations, we believe that this RE apparatus is closer to the physiological context observed in humans.

Show MeSH
Related in: MedlinePlus