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Human blood-vessel-derived stem cells for tissue repair and regeneration.

Chen CW, Corselli M, Péault B, Huard J - J. Biomed. Biotechnol. (2012)

Bottom Line: Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues.Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively.The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA. chc88@pitt.edu

ABSTRACT
Multipotent stem/progenitor cells with similar developmental potentials have been independently identified from diverse human tissue/organ cultures. The increasing recognition of the vascular/perivascular origin of mesenchymal precursors suggested blood vessels being a systemic source of adult stem/progenitor cells. Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues. Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively. MECs and pericytes efficiently regenerate myofibers in injured and dystrophic skeletal muscles as well as improve cardiac function after myocardial infarction. The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined. Our recent finding that MECs and pericytes can be purified from cryogenically banked human primary muscle cell culture further indicates their potential applications in personalized regenerative medicine.

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Related in: MedlinePlus

Distinct morphology of the three purified subpopulations of human blood-vessel-derived stem cells (hBVSCs) in culture: myogenic endothelial cell (MEC), pericyte, and adventitial cell (AC) (100x).
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fig1: Distinct morphology of the three purified subpopulations of human blood-vessel-derived stem cells (hBVSCs) in culture: myogenic endothelial cell (MEC), pericyte, and adventitial cell (AC) (100x).

Mentions: We and other laboratories recently reported the existence of three distinct subpopulations of mesodermal precursors within the blood vessel walls through anatomic and molecular identifications. At least one precursor subset, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs) (Figure 1), was contained in each of the three tunicae of blood vessels: intima, media, and adventitia, respectively [26, 40, 45–47].


Human blood-vessel-derived stem cells for tissue repair and regeneration.

Chen CW, Corselli M, Péault B, Huard J - J. Biomed. Biotechnol. (2012)

Distinct morphology of the three purified subpopulations of human blood-vessel-derived stem cells (hBVSCs) in culture: myogenic endothelial cell (MEC), pericyte, and adventitial cell (AC) (100x).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303622&req=5

fig1: Distinct morphology of the three purified subpopulations of human blood-vessel-derived stem cells (hBVSCs) in culture: myogenic endothelial cell (MEC), pericyte, and adventitial cell (AC) (100x).
Mentions: We and other laboratories recently reported the existence of three distinct subpopulations of mesodermal precursors within the blood vessel walls through anatomic and molecular identifications. At least one precursor subset, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs) (Figure 1), was contained in each of the three tunicae of blood vessels: intima, media, and adventitia, respectively [26, 40, 45–47].

Bottom Line: Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues.Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively.The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA. chc88@pitt.edu

ABSTRACT
Multipotent stem/progenitor cells with similar developmental potentials have been independently identified from diverse human tissue/organ cultures. The increasing recognition of the vascular/perivascular origin of mesenchymal precursors suggested blood vessels being a systemic source of adult stem/progenitor cells. Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues. Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively. MECs and pericytes efficiently regenerate myofibers in injured and dystrophic skeletal muscles as well as improve cardiac function after myocardial infarction. The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined. Our recent finding that MECs and pericytes can be purified from cryogenically banked human primary muscle cell culture further indicates their potential applications in personalized regenerative medicine.

Show MeSH
Related in: MedlinePlus