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In situ absorption in rat intestinal tract of solid dispersion of annonaceous acetogenins.

Dang YJ, Feng HZ, Zhang L, Hu CH, Zhu CY - Gastroenterol Res Pract (2012)

Bottom Line: Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs.The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method.So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China.

ABSTRACT
Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat's intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat's intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.

No MeSH data available.


HPLC Chromatograms of A: Cherimolin-1, B: annonacin, C: Squamocin, D: annonin-VI. (a) blank K-R buffer solution; (b) the four compounds in ACGs extract.
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fig2: HPLC Chromatograms of A: Cherimolin-1, B: annonacin, C: Squamocin, D: annonin-VI. (a) blank K-R buffer solution; (b) the four compounds in ACGs extract.

Mentions: As the Figure 2 shows, under the HPLC condition, no interference peaks were observed from the K-R buffer solution as well as the pre-dose intestinal samples from the SD rats which participated in the absorption study of ACGs. This method provided a sufficient specificity.


In situ absorption in rat intestinal tract of solid dispersion of annonaceous acetogenins.

Dang YJ, Feng HZ, Zhang L, Hu CH, Zhu CY - Gastroenterol Res Pract (2012)

HPLC Chromatograms of A: Cherimolin-1, B: annonacin, C: Squamocin, D: annonin-VI. (a) blank K-R buffer solution; (b) the four compounds in ACGs extract.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303619&req=5

fig2: HPLC Chromatograms of A: Cherimolin-1, B: annonacin, C: Squamocin, D: annonin-VI. (a) blank K-R buffer solution; (b) the four compounds in ACGs extract.
Mentions: As the Figure 2 shows, under the HPLC condition, no interference peaks were observed from the K-R buffer solution as well as the pre-dose intestinal samples from the SD rats which participated in the absorption study of ACGs. This method provided a sufficient specificity.

Bottom Line: Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs.The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method.So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.

View Article: PubMed Central - PubMed

Affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China.

ABSTRACT
Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility. Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs. The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method. We studied the absorption property of ACGs in rat's intestine, which showed there was a good absorption and uptake percentages with solid dispersion. The study on uptake percentage in different regions of rat's intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences. So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.

No MeSH data available.