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Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract of Mirabilis jalapa L. Root on Normal and Diabetic Mice.

Zhou JY, Zhou SW, Zeng SY, Zhou JY, Jiang MJ, He Y - Evid Based Complement Alternat Med (2012)

Bottom Line: Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice.Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice.These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

View Article: PubMed Central - PubMed

Affiliation: Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

ABSTRACT
The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

No MeSH data available.


Related in: MedlinePlus

Effects of single and repeated EEM administration on blood glucose level in normal and diabetic mice. Data are expressed as mean ± SD, n = 10 mice per group. *P < 0.01, compared to normal control. #P < 0.01, compared to diabetic control. ▼P < 0.01, compared to before administration.
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fig2: Effects of single and repeated EEM administration on blood glucose level in normal and diabetic mice. Data are expressed as mean ± SD, n = 10 mice per group. *P < 0.01, compared to normal control. #P < 0.01, compared to diabetic control. ▼P < 0.01, compared to before administration.

Mentions: In streptozotocin-induced untreated diabetic mice, fasting blood glucose level was significantly higher than that of untreated normal ones both before and after EEM administration (P < 0.01). But fasting blood glucose level did not change after single administration of EEM at doses of 2, 4, and 8 g/kg either in normal or diabetic mice (Figure 2(a)). In the diabetic mice, glibenclamide produced significant hypoglycemic effect. But glibenclamide had no effect on glucose level of normal mice.


Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract of Mirabilis jalapa L. Root on Normal and Diabetic Mice.

Zhou JY, Zhou SW, Zeng SY, Zhou JY, Jiang MJ, He Y - Evid Based Complement Alternat Med (2012)

Effects of single and repeated EEM administration on blood glucose level in normal and diabetic mice. Data are expressed as mean ± SD, n = 10 mice per group. *P < 0.01, compared to normal control. #P < 0.01, compared to diabetic control. ▼P < 0.01, compared to before administration.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303618&req=5

fig2: Effects of single and repeated EEM administration on blood glucose level in normal and diabetic mice. Data are expressed as mean ± SD, n = 10 mice per group. *P < 0.01, compared to normal control. #P < 0.01, compared to diabetic control. ▼P < 0.01, compared to before administration.
Mentions: In streptozotocin-induced untreated diabetic mice, fasting blood glucose level was significantly higher than that of untreated normal ones both before and after EEM administration (P < 0.01). But fasting blood glucose level did not change after single administration of EEM at doses of 2, 4, and 8 g/kg either in normal or diabetic mice (Figure 2(a)). In the diabetic mice, glibenclamide produced significant hypoglycemic effect. But glibenclamide had no effect on glucose level of normal mice.

Bottom Line: Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice.Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice.These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

View Article: PubMed Central - PubMed

Affiliation: Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

ABSTRACT
The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

No MeSH data available.


Related in: MedlinePlus