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Role of angiogenesis in the pathogenesis of oral lichen planus.

Mittal N, Shankari GM, Palaskar S - J Oral Maxillofac Pathol (2012)

Bottom Line: There is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in the induction of aberrant angiogenesis.Reticular OLP had mean MVD of 84.61 and erosive OLP had mean MVD of 129.71, showing relatively greater angiogenesis in erosive OLP as compared to reticular OLP.Thus, angiogenesis can be considered to play a role in both the etiopathogenesis and the progression of OLP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Desh Bhagat Dental College, Sri Muktsar Sahib, Punjab, India.

ABSTRACT

Background: The etiology of oral lichen planus (OLP) is not fully understood. It is generally considered to be a T-cell mediated chronic inflammatory oral mucosal disease. There is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in the induction of aberrant angiogenesis.

Aim: Our aim was to evaluate the role of angiogenesis in the pathogenesis of OLP by immunohistochemistry, using the CD34 antibody.

Materials and methods: Forty tissue sections (7 of erosive lichen planus, 18 of reticular oral lichen planus, and 15 of normal oral mucosa), were assessed for microvessel density (MVD) in five selected areas of high inflammatory infiltrate by immunohistochemistry for the expression of CD34 antibody.

Results and conclusion: The mean MVD was 44.47 in the control group (normal oral mucosa) and 97.24 in the OLP group, showing that there is increased angiogenesis in the latter. Reticular OLP had mean MVD of 84.61 and erosive OLP had mean MVD of 129.71, showing relatively greater angiogenesis in erosive OLP as compared to reticular OLP. Thus, angiogenesis can be considered to play a role in both the etiopathogenesis and the progression of OLP.

No MeSH data available.


Related in: MedlinePlus

CD34-stained brown-colored blood vessels in normal oral mucosal tissue
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Figure 1: CD34-stained brown-colored blood vessels in normal oral mucosal tissue

Mentions: Microvessels were highlighted on the sections of OLP and normal oral mucosal tissue by immunostaining with anti-CD34 monoclonal antibody [Figures 1–3]. Any single brown-stained cell or cluster of endothelial cells that were clearly separated from adjacent microvessels, histiocytes, and other connective tissue elements were considered as a single vessel.


Role of angiogenesis in the pathogenesis of oral lichen planus.

Mittal N, Shankari GM, Palaskar S - J Oral Maxillofac Pathol (2012)

CD34-stained brown-colored blood vessels in normal oral mucosal tissue
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3303522&req=5

Figure 1: CD34-stained brown-colored blood vessels in normal oral mucosal tissue
Mentions: Microvessels were highlighted on the sections of OLP and normal oral mucosal tissue by immunostaining with anti-CD34 monoclonal antibody [Figures 1–3]. Any single brown-stained cell or cluster of endothelial cells that were clearly separated from adjacent microvessels, histiocytes, and other connective tissue elements were considered as a single vessel.

Bottom Line: There is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in the induction of aberrant angiogenesis.Reticular OLP had mean MVD of 84.61 and erosive OLP had mean MVD of 129.71, showing relatively greater angiogenesis in erosive OLP as compared to reticular OLP.Thus, angiogenesis can be considered to play a role in both the etiopathogenesis and the progression of OLP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Desh Bhagat Dental College, Sri Muktsar Sahib, Punjab, India.

ABSTRACT

Background: The etiology of oral lichen planus (OLP) is not fully understood. It is generally considered to be a T-cell mediated chronic inflammatory oral mucosal disease. There is increasing evidence that chronic inflammation is linked to the diseases associated with endothelial dysfunction and is involved in the induction of aberrant angiogenesis.

Aim: Our aim was to evaluate the role of angiogenesis in the pathogenesis of OLP by immunohistochemistry, using the CD34 antibody.

Materials and methods: Forty tissue sections (7 of erosive lichen planus, 18 of reticular oral lichen planus, and 15 of normal oral mucosa), were assessed for microvessel density (MVD) in five selected areas of high inflammatory infiltrate by immunohistochemistry for the expression of CD34 antibody.

Results and conclusion: The mean MVD was 44.47 in the control group (normal oral mucosa) and 97.24 in the OLP group, showing that there is increased angiogenesis in the latter. Reticular OLP had mean MVD of 84.61 and erosive OLP had mean MVD of 129.71, showing relatively greater angiogenesis in erosive OLP as compared to reticular OLP. Thus, angiogenesis can be considered to play a role in both the etiopathogenesis and the progression of OLP.

No MeSH data available.


Related in: MedlinePlus