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Basaloid squamous cell carcinoma.

Poornima V, Patankar SR, Gokul S, Khot K - J Oral Maxillofac Pathol (2012)

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology and Microbiology, Dr. G D Pol Foundation YMT Dental College and Hospital, Navi Mumbai, India.

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On clinical examination, a proliferative verrucous growth was noticed in the lower anterior region, extending from 33 to 43 and crossing the midline... The lesion was firm in consistency and nontender... Superficial parakeratinized stratified squamous surface epithelium is seen invading the underlying connective tissue [Figure 1]... The connective tissue stroma shows strands and islands of neoplastic epithelial cells... There is a squamous cell component interspersed among the basaloid islands... Surface squamous cell component and deeper glandular component are more distinct... Glandular structures are lined by basaloid, columnar, or mucin-secreting cells... Intracytoplasmic mucin demonstrated by mucicarmine staining helps to differentiate this from the variants of squamous cell carcinoma that show a pseudoglandular pattern of differentiation... Increased mucin is present in the surrounding stroma, with cleft artifact occuring between tumor nests and surrounding stroma because of shrinkage of mucin during fixation and staining... For the diagnosis of carcinoma there should be more than 4–5 mitotic figures per 10 high-powerfields... Islands of odontogenic epithelium lined peripherally by basaloid cells that tend to be cuboidal rather than columnar, surrounding central nests of uniform basaloid-appearing cells... Tumor islands with large central cystic spaces with comedo type of necrosis and a several-cell-layers-thick peripheral rim of tumor cells that are cuboidal/polygonal and have a moderate amount of eosinophilic cytoplasm... Perineural and perivascular invasion is common.

No MeSH data available.


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Tumor islands showing palisaded arrangement of peripheral basaloid cells (H and E, ×40)
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Figure 5: Tumor islands showing palisaded arrangement of peripheral basaloid cells (H and E, ×40)

Mentions: The connective tissue stroma shows strands and islands of neoplastic epithelial cells. These islands show peripheral palisading basaloid-appearing cells with hyperchromatic nuclei, scanty cytoplasm, and central comedo-like necrosis [Figures 2–5].


Basaloid squamous cell carcinoma.

Poornima V, Patankar SR, Gokul S, Khot K - J Oral Maxillofac Pathol (2012)

Tumor islands showing palisaded arrangement of peripheral basaloid cells (H and E, ×40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3303514&req=5

Figure 5: Tumor islands showing palisaded arrangement of peripheral basaloid cells (H and E, ×40)
Mentions: The connective tissue stroma shows strands and islands of neoplastic epithelial cells. These islands show peripheral palisading basaloid-appearing cells with hyperchromatic nuclei, scanty cytoplasm, and central comedo-like necrosis [Figures 2–5].

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology and Microbiology, Dr. G D Pol Foundation YMT Dental College and Hospital, Navi Mumbai, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

On clinical examination, a proliferative verrucous growth was noticed in the lower anterior region, extending from 33 to 43 and crossing the midline... The lesion was firm in consistency and nontender... Superficial parakeratinized stratified squamous surface epithelium is seen invading the underlying connective tissue [Figure 1]... The connective tissue stroma shows strands and islands of neoplastic epithelial cells... There is a squamous cell component interspersed among the basaloid islands... Surface squamous cell component and deeper glandular component are more distinct... Glandular structures are lined by basaloid, columnar, or mucin-secreting cells... Intracytoplasmic mucin demonstrated by mucicarmine staining helps to differentiate this from the variants of squamous cell carcinoma that show a pseudoglandular pattern of differentiation... Increased mucin is present in the surrounding stroma, with cleft artifact occuring between tumor nests and surrounding stroma because of shrinkage of mucin during fixation and staining... For the diagnosis of carcinoma there should be more than 4–5 mitotic figures per 10 high-powerfields... Islands of odontogenic epithelium lined peripherally by basaloid cells that tend to be cuboidal rather than columnar, surrounding central nests of uniform basaloid-appearing cells... Tumor islands with large central cystic spaces with comedo type of necrosis and a several-cell-layers-thick peripheral rim of tumor cells that are cuboidal/polygonal and have a moderate amount of eosinophilic cytoplasm... Perineural and perivascular invasion is common.

No MeSH data available.


Related in: MedlinePlus