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Amino acid and vitamin supplementation improved health conditions in elderly participants.

Ohtani M, Kawada S, Seki T, Okamoto Y - J Clin Biochem Nutr (2011)

Bottom Line: The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people.One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study.At post-point, natural killer cell activity in the outpatient and inpatient groups increased significantly compared to baseline.

View Article: PubMed Central - PubMed

Affiliation: Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa-shi, Chiba 277-8563, Japan.

ABSTRACT
The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people. One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study. A mixture supplementation with amino acids containing arginine (500 mg/day), glutamine (600 mg/day), and leucine (1200 mg/day), and 11 kinds of vitamins was daily administrated for 8 weeks. In both groups, general blood biomarkers such as white blood cell count, natural killer cell activity, and C-reactive protein levels were measured. All measurements were taken before (baseline), at 4 weeks (mid-point), and after each trial (post-point). At mid-point, natural killer cell activity in the outpatient group increased significantly compared to baseline. At post-point, natural killer cell activity in the outpatient and inpatient groups increased significantly compared to baseline. The other blood biomarkers did not show any significant change throughout the trial. This pilot study suggested that a mixture of arginine, glutamine, leucine, and vitamins is useful to support innate immunity in unhealthy older people, even if their diseases, symptoms, and prescribed medicines are different.

No MeSH data available.


Changes in body composition (a). Throughout the clinical trial, body weight (BW), lean body mass (LBM), and fat mass (FM) in the outpatients did not change with amino acid and vitamin supplementation. NK cell activity in the inpatient and outpatient groups increased with amino acid and vitamin supplementation (b).
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Figure 1: Changes in body composition (a). Throughout the clinical trial, body weight (BW), lean body mass (LBM), and fat mass (FM) in the outpatients did not change with amino acid and vitamin supplementation. NK cell activity in the inpatient and outpatient groups increased with amino acid and vitamin supplementation (b).

Mentions: The outpatients mean habitual nutrient intake was 34.1 ± 3.8 kcal/kg/day including 1.27 ± 0.32 g protein/kg/day. Body weight and body composition in the outpatients did not change throughout the trial (Fig. 1a). At mid-point, NK cell activity in the bedridden inpatients tended to increase compared to baseline (p = 0.08), and at post-point, it increased significantly compared to baseline (p = 0.03) (Fig. 1b). At mid-point (p = 0.01) and post-point (p = 0.001), NK cell activity in the outpatients increased significantly compared to baseline (Fig. 1b). The other biomarkers did not change throughout the trial (Table 4). Febrile frequency in the bedridden inpatients did not change throughout the trial, whereas at the second month in the control inpatients, it increased significantly compared to the first month (p = 0.03) (Fig. 2). Febrile frequency did not show a condition × time interaction.


Amino acid and vitamin supplementation improved health conditions in elderly participants.

Ohtani M, Kawada S, Seki T, Okamoto Y - J Clin Biochem Nutr (2011)

Changes in body composition (a). Throughout the clinical trial, body weight (BW), lean body mass (LBM), and fat mass (FM) in the outpatients did not change with amino acid and vitamin supplementation. NK cell activity in the inpatient and outpatient groups increased with amino acid and vitamin supplementation (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3303480&req=5

Figure 1: Changes in body composition (a). Throughout the clinical trial, body weight (BW), lean body mass (LBM), and fat mass (FM) in the outpatients did not change with amino acid and vitamin supplementation. NK cell activity in the inpatient and outpatient groups increased with amino acid and vitamin supplementation (b).
Mentions: The outpatients mean habitual nutrient intake was 34.1 ± 3.8 kcal/kg/day including 1.27 ± 0.32 g protein/kg/day. Body weight and body composition in the outpatients did not change throughout the trial (Fig. 1a). At mid-point, NK cell activity in the bedridden inpatients tended to increase compared to baseline (p = 0.08), and at post-point, it increased significantly compared to baseline (p = 0.03) (Fig. 1b). At mid-point (p = 0.01) and post-point (p = 0.001), NK cell activity in the outpatients increased significantly compared to baseline (Fig. 1b). The other biomarkers did not change throughout the trial (Table 4). Febrile frequency in the bedridden inpatients did not change throughout the trial, whereas at the second month in the control inpatients, it increased significantly compared to the first month (p = 0.03) (Fig. 2). Febrile frequency did not show a condition × time interaction.

Bottom Line: The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people.One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study.At post-point, natural killer cell activity in the outpatient and inpatient groups increased significantly compared to baseline.

View Article: PubMed Central - PubMed

Affiliation: Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa-shi, Chiba 277-8563, Japan.

ABSTRACT
The purpose of this study was to investigate the effects of supplementation with amino acids and vitamins on health conditions in unhealthy older people. One bedridden inpatient group (n = 10; mean age, 79.8 ± 8.5 y) and one outpatient group (n = 9; mean age, 72.9 ± 12.2 y) participated in this study. A mixture supplementation with amino acids containing arginine (500 mg/day), glutamine (600 mg/day), and leucine (1200 mg/day), and 11 kinds of vitamins was daily administrated for 8 weeks. In both groups, general blood biomarkers such as white blood cell count, natural killer cell activity, and C-reactive protein levels were measured. All measurements were taken before (baseline), at 4 weeks (mid-point), and after each trial (post-point). At mid-point, natural killer cell activity in the outpatient group increased significantly compared to baseline. At post-point, natural killer cell activity in the outpatient and inpatient groups increased significantly compared to baseline. The other blood biomarkers did not show any significant change throughout the trial. This pilot study suggested that a mixture of arginine, glutamine, leucine, and vitamins is useful to support innate immunity in unhealthy older people, even if their diseases, symptoms, and prescribed medicines are different.

No MeSH data available.