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Acid – base disturbances in critically ill septic patients: a longitudinal quantitative study

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Applying a quantitative methodology, we described the acid – base status of severe septic patients in the first 5 days after admission to the ICU... At admission to the ICU, septic patients presented a severe metabolic acidosis with an average pH of 7.29; PCO2 = 36 mmHg and SBE = -8.0... Figure 1 presents the several components of the metabolic acid – base disturbances found on the first day in the ICU... We found that the magnitude of metabolic acidosis, measured by the SBE, was greater among the nonsurvivors than the survivors... However, the components of acid – base disturbances are kept proportionally constant among different clinical outcome subgroups... During the study period, the survivor group presented an increased SBE from -6.4 to -1.5 due to a significant decrease in serum lactate level and SIG... In contrast, the nonsurvivor group became even more acidemic due to an increase in the PCO2 and persistence of a highly negative SBE... From the metabolic point of view, no significant change occurred in this group from the first to the last day of the study, except for a small increase in the phosphate serum level... Over the study period, the survivor group partially corrected its acidosis mainly through the disappearance of unmeasured anions and lactate... Nonsurvivors did not change significantly their metabolic acidosis over time.

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Components of SBE on the first day.
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Figure 1: Components of SBE on the first day.

Mentions: Sixty patients were included in the study. At admission to the ICU, septic patients presented a severe metabolic acidosis with an average pH of 7.29; PCO2 = 36 mmHg and SBE = -8.0. Figure 1 presents the several components of the metabolic acid – base disturbances found on the first day in the ICU. We found that the magnitude of metabolic acidosis, measured by the SBE, was greater among the nonsurvivors than the survivors. However, the components of acid – base disturbances are kept proportionally constant among different clinical outcome subgroups.


Acid – base disturbances in critically ill septic patients: a longitudinal quantitative study
Components of SBE on the first day.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3301148&req=5

Figure 1: Components of SBE on the first day.
Mentions: Sixty patients were included in the study. At admission to the ICU, septic patients presented a severe metabolic acidosis with an average pH of 7.29; PCO2 = 36 mmHg and SBE = -8.0. Figure 1 presents the several components of the metabolic acid – base disturbances found on the first day in the ICU. We found that the magnitude of metabolic acidosis, measured by the SBE, was greater among the nonsurvivors than the survivors. However, the components of acid – base disturbances are kept proportionally constant among different clinical outcome subgroups.

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Applying a quantitative methodology, we described the acid – base status of severe septic patients in the first 5 days after admission to the ICU... At admission to the ICU, septic patients presented a severe metabolic acidosis with an average pH of 7.29; PCO2 = 36 mmHg and SBE = -8.0... Figure 1 presents the several components of the metabolic acid – base disturbances found on the first day in the ICU... We found that the magnitude of metabolic acidosis, measured by the SBE, was greater among the nonsurvivors than the survivors... However, the components of acid – base disturbances are kept proportionally constant among different clinical outcome subgroups... During the study period, the survivor group presented an increased SBE from -6.4 to -1.5 due to a significant decrease in serum lactate level and SIG... In contrast, the nonsurvivor group became even more acidemic due to an increase in the PCO2 and persistence of a highly negative SBE... From the metabolic point of view, no significant change occurred in this group from the first to the last day of the study, except for a small increase in the phosphate serum level... Over the study period, the survivor group partially corrected its acidosis mainly through the disappearance of unmeasured anions and lactate... Nonsurvivors did not change significantly their metabolic acidosis over time.

No MeSH data available.