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Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices.

Allain V, Bourgaux C, Couvreur P - Nucleic Acids Res. (2011)

Bottom Line: This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly.Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids.Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Université Paris-Sud 11, Faculté de Pharmacie, 5 rue J.B. Clément, 92296 Châtenay-Malabry, France.

ABSTRACT
This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of the lipid chains and base-base interactions. Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids. Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.

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Related in: MedlinePlus

Self-assembly of SQddC. (A) SAXS pattern of the Pn3m and Ia3d inverse bicontinuous cubic phases shown on both linear and log (inset) scales. The stars denote the reflections of the Ia3d phase. (B) Schematic drawing of the Pn3m and Ia3d inverse bicontinuous cubic phases. (C) TEM image after freeze fracture of a SQddC cubosome [redrawn from Ref. (15)].
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gkr681-F7: Self-assembly of SQddC. (A) SAXS pattern of the Pn3m and Ia3d inverse bicontinuous cubic phases shown on both linear and log (inset) scales. The stars denote the reflections of the Ia3d phase. (B) Schematic drawing of the Pn3m and Ia3d inverse bicontinuous cubic phases. (C) TEM image after freeze fracture of a SQddC cubosome [redrawn from Ref. (15)].

Mentions: Squalenoylation of ddC (SQddC) yielded spontaneous formation of nanoassemblies with cubic inner symmetry upon nanoprecipitation of SQddC in excess water. Two lattices of space group Pn3m (lattice parameter a = 77.2 Å) and Ia3d (a = 122.5 Å) were identified using SAXS. SQddC molecules formed bilayers folded like a periodic minimal surface, either D (Diamond) or P (Primitive) surfaces (Figure 7) (15).Figure 7.


Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices.

Allain V, Bourgaux C, Couvreur P - Nucleic Acids Res. (2011)

Self-assembly of SQddC. (A) SAXS pattern of the Pn3m and Ia3d inverse bicontinuous cubic phases shown on both linear and log (inset) scales. The stars denote the reflections of the Ia3d phase. (B) Schematic drawing of the Pn3m and Ia3d inverse bicontinuous cubic phases. (C) TEM image after freeze fracture of a SQddC cubosome [redrawn from Ref. (15)].
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3300006&req=5

gkr681-F7: Self-assembly of SQddC. (A) SAXS pattern of the Pn3m and Ia3d inverse bicontinuous cubic phases shown on both linear and log (inset) scales. The stars denote the reflections of the Ia3d phase. (B) Schematic drawing of the Pn3m and Ia3d inverse bicontinuous cubic phases. (C) TEM image after freeze fracture of a SQddC cubosome [redrawn from Ref. (15)].
Mentions: Squalenoylation of ddC (SQddC) yielded spontaneous formation of nanoassemblies with cubic inner symmetry upon nanoprecipitation of SQddC in excess water. Two lattices of space group Pn3m (lattice parameter a = 77.2 Å) and Ia3d (a = 122.5 Å) were identified using SAXS. SQddC molecules formed bilayers folded like a periodic minimal surface, either D (Diamond) or P (Primitive) surfaces (Figure 7) (15).Figure 7.

Bottom Line: This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly.Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids.Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Université Paris-Sud 11, Faculté de Pharmacie, 5 rue J.B. Clément, 92296 Châtenay-Malabry, France.

ABSTRACT
This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of the lipid chains and base-base interactions. Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids. Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.

Show MeSH
Related in: MedlinePlus