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Cardiovascular and hormonal responses to static handgrip in young and older healthy men.

Krzemiński K, Cybulski G, Ziemba A, Nazar K - Eur. J. Appl. Physiol. (2011)

Bottom Line: SV decreased only in older men (p < 0.001).The baseline plasma ADM and catecholamines were higher in older man compared to young subjects.These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego str, 02-106 Warsaw, Poland. krzem@cmdik.pan.pl

ABSTRACT
The purpose of this study was to investigate the effect of age on cardiovascular changes and plasma concentrations of adrenomedullin (ADM), catecholamines, endothelin-1 (ET-1) and plasma renin activity (PRA) in healthy men. A total of 15 young (21 ± 0.3 years) and 15 older (64 ± 0.7 years) healthy men performed two 3-min bouts of static handgrip at 30% of maximal voluntary contraction, alternately with each hand without any break between the bouts. During exercise heart rate (HR), blood pressure (BP), stroke volume (SV) and pre-ejection period (PEP) and left ventricle ejection time (LVET) were measured. Blood samples were taken before exercise, at the end of both exercise bouts and in the fifth minute of the recovery period. The handgrip-induced increases in HR and cardiac output were significantly smaller in older than in young men (p < 0.01). SV decreased only in older men (p < 0.001). There were no differences between groups in BP increases. The baseline plasma ADM and catecholamines were higher in older man compared to young subjects. Handgrip caused increases in plasma ADM, ET-1 and PRA only in older men (p < 0.05). The increases in plasma ADM correlated positively with those of noradrenaline (NA), PRA, ET-1 and LVET and negatively with changes in total peripheral resistance (TPR), SV, PEP and PEP/LVET ratio. The increases in plasma ET-1 correlated positively with those of NA, PRA, TPR, mean BP and SV. These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

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The relationships between the changes in plasma adrenomedullin (∆ADM) and those of: noradrenaline (∆NA), endothellin-1 (∆ET-1), plasma renin activity (∆PRA) as well as between ∆ET-1 and ∆PRA in older subjects. All variables are expressed as percentage of baseline values
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Fig2: The relationships between the changes in plasma adrenomedullin (∆ADM) and those of: noradrenaline (∆NA), endothellin-1 (∆ET-1), plasma renin activity (∆PRA) as well as between ∆ET-1 and ∆PRA in older subjects. All variables are expressed as percentage of baseline values

Mentions: A significant positive relationships between baseline values of plasma ADM and plasma NA concentrations were ascertained for older and younger groups of subjects (r = 0.76, P < 0.001; r = 0.62, P < 0.01; respectively). The exercise-evoked increases in plasma ADM concentrations expressed as percentage of baseline values correlated with those of plasma NA, ET-1 and PRA only in the older men (r = 0.80, P < 0.001; r = 0.74, P < 0.001 and r = 0.84, P < 0.001; respectively; Fig. 2). The exercise-evoked increases in plasma ET-1 concentrations expressed as percentage of baseline values correlated with those of plasma NA only in the older men (r = 0.56, P < 0.05).Fig. 2


Cardiovascular and hormonal responses to static handgrip in young and older healthy men.

Krzemiński K, Cybulski G, Ziemba A, Nazar K - Eur. J. Appl. Physiol. (2011)

The relationships between the changes in plasma adrenomedullin (∆ADM) and those of: noradrenaline (∆NA), endothellin-1 (∆ET-1), plasma renin activity (∆PRA) as well as between ∆ET-1 and ∆PRA in older subjects. All variables are expressed as percentage of baseline values
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3299973&req=5

Fig2: The relationships between the changes in plasma adrenomedullin (∆ADM) and those of: noradrenaline (∆NA), endothellin-1 (∆ET-1), plasma renin activity (∆PRA) as well as between ∆ET-1 and ∆PRA in older subjects. All variables are expressed as percentage of baseline values
Mentions: A significant positive relationships between baseline values of plasma ADM and plasma NA concentrations were ascertained for older and younger groups of subjects (r = 0.76, P < 0.001; r = 0.62, P < 0.01; respectively). The exercise-evoked increases in plasma ADM concentrations expressed as percentage of baseline values correlated with those of plasma NA, ET-1 and PRA only in the older men (r = 0.80, P < 0.001; r = 0.74, P < 0.001 and r = 0.84, P < 0.001; respectively; Fig. 2). The exercise-evoked increases in plasma ET-1 concentrations expressed as percentage of baseline values correlated with those of plasma NA only in the older men (r = 0.56, P < 0.05).Fig. 2

Bottom Line: SV decreased only in older men (p < 0.001).The baseline plasma ADM and catecholamines were higher in older man compared to young subjects.These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego str, 02-106 Warsaw, Poland. krzem@cmdik.pan.pl

ABSTRACT
The purpose of this study was to investigate the effect of age on cardiovascular changes and plasma concentrations of adrenomedullin (ADM), catecholamines, endothelin-1 (ET-1) and plasma renin activity (PRA) in healthy men. A total of 15 young (21 ± 0.3 years) and 15 older (64 ± 0.7 years) healthy men performed two 3-min bouts of static handgrip at 30% of maximal voluntary contraction, alternately with each hand without any break between the bouts. During exercise heart rate (HR), blood pressure (BP), stroke volume (SV) and pre-ejection period (PEP) and left ventricle ejection time (LVET) were measured. Blood samples were taken before exercise, at the end of both exercise bouts and in the fifth minute of the recovery period. The handgrip-induced increases in HR and cardiac output were significantly smaller in older than in young men (p < 0.01). SV decreased only in older men (p < 0.001). There were no differences between groups in BP increases. The baseline plasma ADM and catecholamines were higher in older man compared to young subjects. Handgrip caused increases in plasma ADM, ET-1 and PRA only in older men (p < 0.05). The increases in plasma ADM correlated positively with those of noradrenaline (NA), PRA, ET-1 and LVET and negatively with changes in total peripheral resistance (TPR), SV, PEP and PEP/LVET ratio. The increases in plasma ET-1 correlated positively with those of NA, PRA, TPR, mean BP and SV. These results revealed that ADM, ET-1 and angiotensin II can contribute to maintain vascular tone during static exercise in older but not in younger men.

Show MeSH
Related in: MedlinePlus