Limits...
Long-term lead elimination from plasma and whole blood after poisoning.

Rentschler G, Broberg K, Lundh T, Skerfving S - Int Arch Occup Environ Health (2011)

Bottom Line: Kinetics after end of exposure was modelled.Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

View Article: PubMed Central - PubMed

Affiliation: Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se

ABSTRACT

Objective: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

Methods: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

Conclusion: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

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Related in: MedlinePlus

Relationship between lead levels in urine (U–Pb) and plasma (P–Pb) in sequential samples from five cases of poisoning. The association between U–Pb and P–Pb follows the equation U–Pb = 12 + 22*P–Pb
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Fig3: Relationship between lead levels in urine (U–Pb) and plasma (P–Pb) in sequential samples from five cases of poisoning. The association between U–Pb and P–Pb follows the equation U–Pb = 12 + 22*P–Pb

Mentions: There seemed to be a rectilinear relationship between U–Pb and P–Pb; the former expressed as μg/g crea was 22 times higher than the latter (R2 linear = 0.5; p < 0.001), expressed as μg/L (Fig. 3).Fig. 3


Long-term lead elimination from plasma and whole blood after poisoning.

Rentschler G, Broberg K, Lundh T, Skerfving S - Int Arch Occup Environ Health (2011)

Relationship between lead levels in urine (U–Pb) and plasma (P–Pb) in sequential samples from five cases of poisoning. The association between U–Pb and P–Pb follows the equation U–Pb = 12 + 22*P–Pb
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3299963&req=5

Fig3: Relationship between lead levels in urine (U–Pb) and plasma (P–Pb) in sequential samples from five cases of poisoning. The association between U–Pb and P–Pb follows the equation U–Pb = 12 + 22*P–Pb
Mentions: There seemed to be a rectilinear relationship between U–Pb and P–Pb; the former expressed as μg/g crea was 22 times higher than the latter (R2 linear = 0.5; p < 0.001), expressed as μg/L (Fig. 3).Fig. 3

Bottom Line: Kinetics after end of exposure was modelled.Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

View Article: PubMed Central - PubMed

Affiliation: Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se

ABSTRACT

Objective: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

Methods: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

Conclusion: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

Show MeSH
Related in: MedlinePlus