Limits...
Long-term lead elimination from plasma and whole blood after poisoning.

Rentschler G, Broberg K, Lundh T, Skerfving S - Int Arch Occup Environ Health (2011)

Bottom Line: Kinetics after end of exposure was modelled.Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

View Article: PubMed Central - PubMed

Affiliation: Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se

ABSTRACT

Objective: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

Methods: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

Conclusion: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

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Related in: MedlinePlus

Lead elimination from plasma (P–Pb; a) and whole blood (B–Pb; b) during the first 800 days after end of exposure in five cases of poisoning
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Fig1: Lead elimination from plasma (P–Pb; a) and whole blood (B–Pb; b) during the first 800 days after end of exposure in five cases of poisoning

Mentions: The median P–Pb at first sampling (median 5, range 1–74 days after end of exposure) was 17 (range 2–42) μg/L (Fig. 1a). The modelled median value for P–Pb (C1 + C2) was 23 (range 3–38) μg/L at time t = 0. In Cases 1–4, the median of C2 was 0.65 (range 0.6–0.8) μg/L, in Case 5 1.6 μg/L.Fig. 1


Long-term lead elimination from plasma and whole blood after poisoning.

Rentschler G, Broberg K, Lundh T, Skerfving S - Int Arch Occup Environ Health (2011)

Lead elimination from plasma (P–Pb; a) and whole blood (B–Pb; b) during the first 800 days after end of exposure in five cases of poisoning
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3299963&req=5

Fig1: Lead elimination from plasma (P–Pb; a) and whole blood (B–Pb; b) during the first 800 days after end of exposure in five cases of poisoning
Mentions: The median P–Pb at first sampling (median 5, range 1–74 days after end of exposure) was 17 (range 2–42) μg/L (Fig. 1a). The modelled median value for P–Pb (C1 + C2) was 23 (range 3–38) μg/L at time t = 0. In Cases 1–4, the median of C2 was 0.65 (range 0.6–0.8) μg/L, in Case 5 1.6 μg/L.Fig. 1

Bottom Line: Kinetics after end of exposure was modelled.Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

View Article: PubMed Central - PubMed

Affiliation: Division of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Gerda.Rentschler@med.lu.se

ABSTRACT

Objective: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

Methods: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

Results: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

Conclusion: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

Show MeSH
Related in: MedlinePlus