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Change of Platelet Reactivity to Antiplatelet Therapy after Stenting Procedure for Cerebral Artery Stenosis: VerifyNow Antiplatelet Assay before and after Stenting.

Lee DH, Kim HS, Kim SM, Kwon SU, Suh DC - Neurointervention (2012)

Bottom Line: The two test results were compared in terms of aspirin-reaction unit (ARU), P2Y12 reaction units (PRU), baseline (BASE), and percentage inhibition.For clopidogrel the medians of the pre-BASE, PRU, and percent inhibition were 338 (279-454), 256 (56-325), and 27% (0-57%).There was no in-stent thrombosis and ischemic event in 1-month follow-up.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

ABSTRACT

Purpose: VerifyNow antiplatelet assays were performed before and after stenting for various cerebral artery stenoses to determine the effect of the procedure itself to the function of dual antiplatelets given.

Materials and methods: A total of 30 consecutive patients underwent cerebral arterial stenting procedure were enrolled. The antiplatelet pretreatment regimen was aspirin (100 mg daily) and clopidogrel (300 mg of loading dose followed by 75mg daily). VerifyNow antiplatelet assay performed before and right after stenting. The two test results were compared in terms of aspirin-reaction unit (ARU), P2Y12 reaction units (PRU), baseline (BASE), and percentage inhibition. We evaluated occurrence of any intra-procedural in-stent thrombosis or immediate thromboembolic complication, and ischemic events in 1-month follow-up.

Results: The median Pre-ARU was 418 (range, 350-586). For clopidogrel the medians of the pre-BASE, PRU, and percent inhibition were 338 (279-454), 256 (56-325), and 27% (0-57%). The medians of the post-ARU, BASE, PRU, and percent inhibition after stenting were 469 (range, 389-573), 378 (288-453), 274 (81-370), and 26% (0-79%). There was a significant increase of ARU (p=0.045), BASE (p=0.026), and PRU (p=0.018) before and after stenting. One immediate thromboembolic event was observed in poor-response group after stenting. There was no in-stent thrombosis and ischemic event in 1-month follow-up.

Conclusion: We observed a significant increase of platelet reactivity to dual antiplatelet therapy right after stenting procedure for various cerebral arterial stenoses.

No MeSH data available.


Related in: MedlinePlus

Individual changes of ARU (A) and PRU (B) values before and after the stenting procedures.
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Figure 1: Individual changes of ARU (A) and PRU (B) values before and after the stenting procedures.

Mentions: The median Pre-ARU was 418 (range, 350-586). For clopidogrel the medians of the pre-BASE, PRU, and % inhibition were 338 (range, 279-454), 256 (range, 56-325), and 27% (range, 0-57%). After stenting, the medians of the post-ARU, BASE, PRU, and % inhibition were 469 (range, 389-573), 378 (range, 288-453), 274 (range, 81-370), and 26% (range 0-79%). There were significant changes of ARU (p = 0.045), BASE (p = 0.026), and PRU (p = 0.018) before and after stenting (Fig. 1). Since the BASEs and PRUs increased at the same time, there was no significant difference in percent inhibitions.


Change of Platelet Reactivity to Antiplatelet Therapy after Stenting Procedure for Cerebral Artery Stenosis: VerifyNow Antiplatelet Assay before and after Stenting.

Lee DH, Kim HS, Kim SM, Kwon SU, Suh DC - Neurointervention (2012)

Individual changes of ARU (A) and PRU (B) values before and after the stenting procedures.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3299946&req=5

Figure 1: Individual changes of ARU (A) and PRU (B) values before and after the stenting procedures.
Mentions: The median Pre-ARU was 418 (range, 350-586). For clopidogrel the medians of the pre-BASE, PRU, and % inhibition were 338 (range, 279-454), 256 (range, 56-325), and 27% (range, 0-57%). After stenting, the medians of the post-ARU, BASE, PRU, and % inhibition were 469 (range, 389-573), 378 (range, 288-453), 274 (range, 81-370), and 26% (range 0-79%). There were significant changes of ARU (p = 0.045), BASE (p = 0.026), and PRU (p = 0.018) before and after stenting (Fig. 1). Since the BASEs and PRUs increased at the same time, there was no significant difference in percent inhibitions.

Bottom Line: The two test results were compared in terms of aspirin-reaction unit (ARU), P2Y12 reaction units (PRU), baseline (BASE), and percentage inhibition.For clopidogrel the medians of the pre-BASE, PRU, and percent inhibition were 338 (279-454), 256 (56-325), and 27% (0-57%).There was no in-stent thrombosis and ischemic event in 1-month follow-up.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

ABSTRACT

Purpose: VerifyNow antiplatelet assays were performed before and after stenting for various cerebral artery stenoses to determine the effect of the procedure itself to the function of dual antiplatelets given.

Materials and methods: A total of 30 consecutive patients underwent cerebral arterial stenting procedure were enrolled. The antiplatelet pretreatment regimen was aspirin (100 mg daily) and clopidogrel (300 mg of loading dose followed by 75mg daily). VerifyNow antiplatelet assay performed before and right after stenting. The two test results were compared in terms of aspirin-reaction unit (ARU), P2Y12 reaction units (PRU), baseline (BASE), and percentage inhibition. We evaluated occurrence of any intra-procedural in-stent thrombosis or immediate thromboembolic complication, and ischemic events in 1-month follow-up.

Results: The median Pre-ARU was 418 (range, 350-586). For clopidogrel the medians of the pre-BASE, PRU, and percent inhibition were 338 (279-454), 256 (56-325), and 27% (0-57%). The medians of the post-ARU, BASE, PRU, and percent inhibition after stenting were 469 (range, 389-573), 378 (288-453), 274 (81-370), and 26% (0-79%). There was a significant increase of ARU (p=0.045), BASE (p=0.026), and PRU (p=0.018) before and after stenting. One immediate thromboembolic event was observed in poor-response group after stenting. There was no in-stent thrombosis and ischemic event in 1-month follow-up.

Conclusion: We observed a significant increase of platelet reactivity to dual antiplatelet therapy right after stenting procedure for various cerebral arterial stenoses.

No MeSH data available.


Related in: MedlinePlus