Limits...
CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung.

Terada T - Diagn Pathol (2012)

Bottom Line: CD3-positive and CD45RO-positive inflammatory T-cells were scattered in small amount.The patient was treated with chemotherapy (CHOP: cyclophosphamide, hydroxydaunorbicin, vincristine, and predonisone), and the lung tumor disappeared.The patient is now free of the lymphoma 10 years after the first manifestation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan. piyo0111jp@yahoo.co.jp

ABSTRACT

Unlabelled: CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed tomography, and magnetic resonance imaging showed a small (2×1×1 cm) opacity of the right upper lobe. Transbronchial lung biopsy was performed. It showed severe proliferation of small lymphocytes. The small lymphocytes were centrocytes-like, and minor plasma cell differentiation was recognized. Lymphoepithelial lesions were scattered. Immunohistochemically, the tumor cells were positive for CD5, CD20, CD43, CD45, CD79α, bcl-2, and κ-chain, but negative for CD2, CD3, CD10, CD21, CD23, CD35, CD45RO, CD56, IgA, IgG, IgM, IgD, λ-chain, TdT, and cyclin D1. The Ki-67 labeling was 10%. CD3-positive and CD45RO-positive inflammatory T-cells were scattered in small amount. The pathological diagnosis was CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. The patient was treated with chemotherapy (CHOP: cyclophosphamide, hydroxydaunorbicin, vincristine, and predonisone), and the lung tumor disappeared. The patient is now free of the lymphoma 10 years after the first manifestation.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1541653085652296.

Show MeSH

Related in: MedlinePlus

Immunohistochemical features. The tumor cells are positive for CD5 (A), CD20 (B), and κ-chain (C). λ-chain was negative (D). A, B, C: ×200. D, x400. The tumor cells were negative for CD3 (E). A small amount of CD3-positive inflammatory cells are seen (E). E: ×200.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3298797&req=5

Figure 2: Immunohistochemical features. The tumor cells are positive for CD5 (A), CD20 (B), and κ-chain (C). λ-chain was negative (D). A, B, C: ×200. D, x400. The tumor cells were negative for CD3 (E). A small amount of CD3-positive inflammatory cells are seen (E). E: ×200.

Mentions: Immunohistochemically, the tumor cells were positive for CD5 (Figure 2A), CD20 (Figure 2B), CD43, CD45, CD79α, bcl-2, and κ-chain (Figure 2C), but negative for λ-chain (Figure 2D), CD2, CD3 (Figure 2E), CD10, CD21, CD23, CD35, CD45RO, CD56, TdT, IgA, IgG, IgM, IgD, and cyclin D1. The Ki-67 labeling was 10%. CD3-positive and CD45RO-positive inflammatory T-cells were scattered in a small amount. Light chains immunostainings showed light chain restriction (Figures 2C and 2D) and a small number of plasma cells (Figure 2C). Methylgreenpyronine staining showed a small number of plasma cells. The pathological diagnosis was CD5-positive MALT lymphoma. After the TBLB, a bone marrow biopsy was performed. It showed normocellular marrow with normal erythroid, granulocytoid and megakaryocytic maturation. No atypical cells were identified in the bone marrow.


CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung.

Terada T - Diagn Pathol (2012)

Immunohistochemical features. The tumor cells are positive for CD5 (A), CD20 (B), and κ-chain (C). λ-chain was negative (D). A, B, C: ×200. D, x400. The tumor cells were negative for CD3 (E). A small amount of CD3-positive inflammatory cells are seen (E). E: ×200.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3298797&req=5

Figure 2: Immunohistochemical features. The tumor cells are positive for CD5 (A), CD20 (B), and κ-chain (C). λ-chain was negative (D). A, B, C: ×200. D, x400. The tumor cells were negative for CD3 (E). A small amount of CD3-positive inflammatory cells are seen (E). E: ×200.
Mentions: Immunohistochemically, the tumor cells were positive for CD5 (Figure 2A), CD20 (Figure 2B), CD43, CD45, CD79α, bcl-2, and κ-chain (Figure 2C), but negative for λ-chain (Figure 2D), CD2, CD3 (Figure 2E), CD10, CD21, CD23, CD35, CD45RO, CD56, TdT, IgA, IgG, IgM, IgD, and cyclin D1. The Ki-67 labeling was 10%. CD3-positive and CD45RO-positive inflammatory T-cells were scattered in a small amount. Light chains immunostainings showed light chain restriction (Figures 2C and 2D) and a small number of plasma cells (Figure 2C). Methylgreenpyronine staining showed a small number of plasma cells. The pathological diagnosis was CD5-positive MALT lymphoma. After the TBLB, a bone marrow biopsy was performed. It showed normocellular marrow with normal erythroid, granulocytoid and megakaryocytic maturation. No atypical cells were identified in the bone marrow.

Bottom Line: CD3-positive and CD45RO-positive inflammatory T-cells were scattered in small amount.The patient was treated with chemotherapy (CHOP: cyclophosphamide, hydroxydaunorbicin, vincristine, and predonisone), and the lung tumor disappeared.The patient is now free of the lymphoma 10 years after the first manifestation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan. piyo0111jp@yahoo.co.jp

ABSTRACT

Unlabelled: CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed tomography, and magnetic resonance imaging showed a small (2×1×1 cm) opacity of the right upper lobe. Transbronchial lung biopsy was performed. It showed severe proliferation of small lymphocytes. The small lymphocytes were centrocytes-like, and minor plasma cell differentiation was recognized. Lymphoepithelial lesions were scattered. Immunohistochemically, the tumor cells were positive for CD5, CD20, CD43, CD45, CD79α, bcl-2, and κ-chain, but negative for CD2, CD3, CD10, CD21, CD23, CD35, CD45RO, CD56, IgA, IgG, IgM, IgD, λ-chain, TdT, and cyclin D1. The Ki-67 labeling was 10%. CD3-positive and CD45RO-positive inflammatory T-cells were scattered in small amount. The pathological diagnosis was CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. The patient was treated with chemotherapy (CHOP: cyclophosphamide, hydroxydaunorbicin, vincristine, and predonisone), and the lung tumor disappeared. The patient is now free of the lymphoma 10 years after the first manifestation.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1541653085652296.

Show MeSH
Related in: MedlinePlus