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Pleural malakoplakia caused by Rhodococcus equi infection in a patient after stem cell transplantation.

Behnes CL, Neumann S, Schweyer S, Radzun HJ - Diagn Pathol (2012)

Bottom Line: Malakoplakia is a disease especially of the urinary tract with typical plaques most frequently observed in the urinary bladder's mucosa.Some of these extravesical malakoplakias are associated with an infection by Rhodococcus equi, a rare human pathogen well known from veterinary medicine.Here we present the first case of a pleural malakoplakia without lung involvement caused by a proved Rhodococcus equi infection.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Göttingen, Robert-Koch-Str, 40, 37075 Göttingen, Germany. clbehnes@med.uni-goettingen.de

ABSTRACT
Malakoplakia is a disease especially of the urinary tract with typical plaques most frequently observed in the urinary bladder's mucosa. In the context of immunosuppression malakoplakia can also occur in other organs. Some of these extravesical malakoplakias are associated with an infection by Rhodococcus equi, a rare human pathogen well known from veterinary medicine. Here we present the first case of a pleural malakoplakia without lung involvement caused by a proved Rhodococcus equi infection.

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Radiologic and macroscopic findings. Axial computer tomography of the chest (A) and the surgical specimen (B) revealed a 12 cm in diameter well circumscribed tumor adherent to pleura and lung.
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Figure 1: Radiologic and macroscopic findings. Axial computer tomography of the chest (A) and the surgical specimen (B) revealed a 12 cm in diameter well circumscribed tumor adherent to pleura and lung.

Mentions: Three months later the patient was admitted to the hospital with retrosternal pain and a reduced general condition. The clinical examinations revealed pneumonic rales over the right lung, slightly elevated temperature, and elevated infection parameters. Primarily the diagnosis of pneumonia was made and the patient was treated with antibiotics and antimycotics. The following computertomography of the chest revealed a 12 cm in diameter and well circumscribed round mass affecting the right upper lobe of the lung (Figure 1). Differential diagnosis included an organized pneumonia or a malignant tumor. The lesion seemed to repress but not to infiltrate the lung and showed no signs of recovery under therapy.


Pleural malakoplakia caused by Rhodococcus equi infection in a patient after stem cell transplantation.

Behnes CL, Neumann S, Schweyer S, Radzun HJ - Diagn Pathol (2012)

Radiologic and macroscopic findings. Axial computer tomography of the chest (A) and the surgical specimen (B) revealed a 12 cm in diameter well circumscribed tumor adherent to pleura and lung.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3298786&req=5

Figure 1: Radiologic and macroscopic findings. Axial computer tomography of the chest (A) and the surgical specimen (B) revealed a 12 cm in diameter well circumscribed tumor adherent to pleura and lung.
Mentions: Three months later the patient was admitted to the hospital with retrosternal pain and a reduced general condition. The clinical examinations revealed pneumonic rales over the right lung, slightly elevated temperature, and elevated infection parameters. Primarily the diagnosis of pneumonia was made and the patient was treated with antibiotics and antimycotics. The following computertomography of the chest revealed a 12 cm in diameter and well circumscribed round mass affecting the right upper lobe of the lung (Figure 1). Differential diagnosis included an organized pneumonia or a malignant tumor. The lesion seemed to repress but not to infiltrate the lung and showed no signs of recovery under therapy.

Bottom Line: Malakoplakia is a disease especially of the urinary tract with typical plaques most frequently observed in the urinary bladder's mucosa.Some of these extravesical malakoplakias are associated with an infection by Rhodococcus equi, a rare human pathogen well known from veterinary medicine.Here we present the first case of a pleural malakoplakia without lung involvement caused by a proved Rhodococcus equi infection.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Göttingen, Robert-Koch-Str, 40, 37075 Göttingen, Germany. clbehnes@med.uni-goettingen.de

ABSTRACT
Malakoplakia is a disease especially of the urinary tract with typical plaques most frequently observed in the urinary bladder's mucosa. In the context of immunosuppression malakoplakia can also occur in other organs. Some of these extravesical malakoplakias are associated with an infection by Rhodococcus equi, a rare human pathogen well known from veterinary medicine. Here we present the first case of a pleural malakoplakia without lung involvement caused by a proved Rhodococcus equi infection.

Show MeSH
Related in: MedlinePlus