MQD--multiplex-quadrature detection in multi-dimensional NMR.
Bottom Line: With multiplex-quadrature detection (MQD) the tasks of coherence selection and quadrature separation in N-dimensional heteronuclear NMR experiments are merged.The minimum number of transients per indirect data point, which have to be combined to give pure-phase spectra, is thus decreased by a factor (3/4)(N-1).This reduction is achieved without adjustable parameters.
Affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Str. 69, 4040 Linz, Austria.Show MeSH
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Mentions: To assess the selection efficiency of the multiplex-phase cycled experiments the programs CCCP23 (for simulating coherence-transfer pathways) and POMA24 (for Cartesian product operator calculations25) were used. The results of the MQD pulse sequences for basic 2D and 3D NMR experiments are summarized in Figure 1. The spectra shown in Figure 3 comparing MQD to States and States-TPPI applying deliberately misset pulses, with and without phase cycling for axial peak suppression, prove the axial peak suppression efficiency to be on par with the slower classical approach.
Affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Str. 69, 4040 Linz, Austria.