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Serum neutrophil gelatinase-associated lipocalin as a marker of kidney function in pregnancy - useful or doubtful?

Małyszko JS, Rams L, Drozdowska-Rams L, Małyszko J - Arch Med Sci (2010)

Bottom Line: Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2(nd) trimester, then decreased in the 3(rd) trimester.Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function.It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Transplantology, Medical University, Bialystok, Poland.

ABSTRACT

Introduction: The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C could reflect kidney function in pregnant healthy women.

Material and methods: The studies were performed on 130 healthy pregnant women (n = 63, 3(rd) trimester; n = 21, 2(nd) trimester; n = 46, 1(st) trimester) and 30 healthy female volunteers. Serum NGAL, cystatin C, IL-6, and hs-CRP were assayed using commercially available kits.

Results: Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2(nd) trimester, then decreased in the 3(rd) trimester. In univariate analysis, NGAL correlated with serum cystatin C, number of pregnancies, white blood cell count, total iron-binding capacity (TIBC), ferritin, and IL-6, and tended to correlate with eGFR. In multiple regression analysis the only predictor of serum NGAL was cystatin C.

Conclusions: Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function. It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.

No MeSH data available.


Related in: MedlinePlus

Correlation between NGAL and cystatin C in pregnant females
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Figure 1: Correlation between NGAL and cystatin C in pregnant females

Mentions: All the data are presented in Table I. We observed a statistically significant fall in serum creatinine in the 2nd trimester together with a rise in eGFR, when compared with the 1st trimester. Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2nd trimester, then decreased in the 3rd trimester. In pregnant females, eGFR (all formulae) was significantly higher in the 2nd trimester when compared to the 1st and 3rd trimesters. NGAL correlated with serum cystatin C (r = 0.25, p < 0.05), number of pregnancies (r = 0.25, p < 0.05), white blood cell count (r = 0.29, p < 0.01), neutrophil count (r = 0.35, p < 0.01), TIBC (r = –0.21, p < 0.05), ferritin (r = 0.36, p < 0.01), and IL-6 (r = 0.23, p < 0.05), and tended to correlate with eGFR. Serum cystatin C correlated with eGFR by MDRD (r = –0.19, p < 0.05), white blood cell count (r = 0.22, p < 0.05), neutrophil count (r = 0.33, p < 0.001), TIBC (r = 0.43, p < 0.001), IL-6 (r = 0.30, p < 0.01), hs-CRP (r = 0.20, p < 0.05), number of pregnancies (r = 0.45, p < 0.001), and NGAL (r = 0.25, p < 0.05) (Figure 1), and tended to correlate with creatinine. In multiple regression analysis the associate of serum NGAL was cystatin C (beta value 0.84, p = 0.008), multiple adjusted r2 = 0.70, F = 2.99, p < 0.034, SE = 5.54.


Serum neutrophil gelatinase-associated lipocalin as a marker of kidney function in pregnancy - useful or doubtful?

Małyszko JS, Rams L, Drozdowska-Rams L, Małyszko J - Arch Med Sci (2010)

Correlation between NGAL and cystatin C in pregnant females
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3298344&req=5

Figure 1: Correlation between NGAL and cystatin C in pregnant females
Mentions: All the data are presented in Table I. We observed a statistically significant fall in serum creatinine in the 2nd trimester together with a rise in eGFR, when compared with the 1st trimester. Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2nd trimester, then decreased in the 3rd trimester. In pregnant females, eGFR (all formulae) was significantly higher in the 2nd trimester when compared to the 1st and 3rd trimesters. NGAL correlated with serum cystatin C (r = 0.25, p < 0.05), number of pregnancies (r = 0.25, p < 0.05), white blood cell count (r = 0.29, p < 0.01), neutrophil count (r = 0.35, p < 0.01), TIBC (r = –0.21, p < 0.05), ferritin (r = 0.36, p < 0.01), and IL-6 (r = 0.23, p < 0.05), and tended to correlate with eGFR. Serum cystatin C correlated with eGFR by MDRD (r = –0.19, p < 0.05), white blood cell count (r = 0.22, p < 0.05), neutrophil count (r = 0.33, p < 0.001), TIBC (r = 0.43, p < 0.001), IL-6 (r = 0.30, p < 0.01), hs-CRP (r = 0.20, p < 0.05), number of pregnancies (r = 0.45, p < 0.001), and NGAL (r = 0.25, p < 0.05) (Figure 1), and tended to correlate with creatinine. In multiple regression analysis the associate of serum NGAL was cystatin C (beta value 0.84, p = 0.008), multiple adjusted r2 = 0.70, F = 2.99, p < 0.034, SE = 5.54.

Bottom Line: Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2(nd) trimester, then decreased in the 3(rd) trimester.Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function.It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Transplantology, Medical University, Bialystok, Poland.

ABSTRACT

Introduction: The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C could reflect kidney function in pregnant healthy women.

Material and methods: The studies were performed on 130 healthy pregnant women (n = 63, 3(rd) trimester; n = 21, 2(nd) trimester; n = 46, 1(st) trimester) and 30 healthy female volunteers. Serum NGAL, cystatin C, IL-6, and hs-CRP were assayed using commercially available kits.

Results: Serum cystatin C rose steadily during the pregnancy, whereas NGAL rose in the 2(nd) trimester, then decreased in the 3(rd) trimester. In univariate analysis, NGAL correlated with serum cystatin C, number of pregnancies, white blood cell count, total iron-binding capacity (TIBC), ferritin, and IL-6, and tended to correlate with eGFR. In multiple regression analysis the only predictor of serum NGAL was cystatin C.

Conclusions: Serum NGAL in pregnancy might reflect subclinical inflammation rather than kidney function. It seems that NGAL, similarly to cystatin C, is not useful to monitor renal function in pregnancy.

No MeSH data available.


Related in: MedlinePlus