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Acute effects of different levels of continuous positive airway pressure on cardiac autonomic modulation in chronic heart failure and chronic obstructive pulmonary disease.

Reis MS, Sampaio LM, Lacerda D, De Oliveira LV, Pereira GB, Pantoni CB, Thommazo LD, Catai AM, Borghi-Silva A - Arch Med Sci (2010)

Bottom Line: Non-invasive ventilation may improve autonomic modulation and ventilatory parameters in severely disabled patients.Respiratory rate, end tidal carbon dioxide (E(T)CO(2)), peripheral oxygen saturation (SpO(2)), heart rate (HR), blood pressure and heart rate variability in the time and frequency domains were measured during spontaneous breathing and under the sham, CPAP5 and CPAP10 conditions.In the CHF group, CPAP5 and CPAP10 increased the SDNN value (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Cardiopulmonary Physiotherapy Laboratory, Center for Research in Physical Exercise, Federal University of São Carlos, São Paulo, Brazil.

ABSTRACT

Introduction: Non-invasive ventilation may improve autonomic modulation and ventilatory parameters in severely disabled patients. The aim of the present study was to evaluate the physiological influence of acute treatment with different levels of continuous positive airway pressure (CPAP) on the autonomic balance of heart and respiratory responses in patients with stable chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF).

Materials and methods: A COPD group (n = 10), CHF group (n = 8) and healthy subjects (n = 10) were evaluated. The participants were randomized to receive three different levels of CPAP on the same day: sham ventilation (Sham), 5 cmH(2)0 (CPAP5) and 10 cmH(2)0 (CPAP10) for 10 min. Respiratory rate, end tidal carbon dioxide (E(T)CO(2)), peripheral oxygen saturation (SpO(2)), heart rate (HR), blood pressure and heart rate variability in the time and frequency domains were measured during spontaneous breathing and under the sham, CPAP5 and CPAP10 conditions.

Results: All groups experienced a reduction in E(T)CO(2) values during treatment with CPAP (p < 0.05). CPAP increased SpO(2) and HR in the COPD group (p < 0.05). The COPD group also had lower RMSSD values during treatment with different levels of CPAP when compared to the control group (p < 0.05). In the CHF group, CPAP5 and CPAP10 increased the SDNN value (p < 0.05). CPAP10 reduced the SDNN value in the COPD group (p < 0.05).

Conclusion: The findings suggest that CPAP may cause improvements in the neural control of heart rate in patients with stable COPD and CHF. For each patient, the "best CPAP level" should be defined as the best respiratory response and autonomic balance.

No MeSH data available.


Related in: MedlinePlus

Flowchart – sample loss of each studied group
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Figure 1: Flowchart – sample loss of each studied group

Mentions: Figure 1 shows the sample loss of each studied group. Table I displays the mean values of the demographic and anthropometric characteristics of the sample, pulmonary function, classification of dyspnoea, echocardiogram, cause of heart failure and medications used in the CHF and COPD groups. No significant differences were found between groups regarding age, height and body mass index (BMI). However, the COPD group had a significantly lower body mass when compared to the control group. As expected, patients with COPD had moderate-to-severe forms of the disease [28].


Acute effects of different levels of continuous positive airway pressure on cardiac autonomic modulation in chronic heart failure and chronic obstructive pulmonary disease.

Reis MS, Sampaio LM, Lacerda D, De Oliveira LV, Pereira GB, Pantoni CB, Thommazo LD, Catai AM, Borghi-Silva A - Arch Med Sci (2010)

Flowchart – sample loss of each studied group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3298341&req=5

Figure 1: Flowchart – sample loss of each studied group
Mentions: Figure 1 shows the sample loss of each studied group. Table I displays the mean values of the demographic and anthropometric characteristics of the sample, pulmonary function, classification of dyspnoea, echocardiogram, cause of heart failure and medications used in the CHF and COPD groups. No significant differences were found between groups regarding age, height and body mass index (BMI). However, the COPD group had a significantly lower body mass when compared to the control group. As expected, patients with COPD had moderate-to-severe forms of the disease [28].

Bottom Line: Non-invasive ventilation may improve autonomic modulation and ventilatory parameters in severely disabled patients.Respiratory rate, end tidal carbon dioxide (E(T)CO(2)), peripheral oxygen saturation (SpO(2)), heart rate (HR), blood pressure and heart rate variability in the time and frequency domains were measured during spontaneous breathing and under the sham, CPAP5 and CPAP10 conditions.In the CHF group, CPAP5 and CPAP10 increased the SDNN value (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Cardiopulmonary Physiotherapy Laboratory, Center for Research in Physical Exercise, Federal University of São Carlos, São Paulo, Brazil.

ABSTRACT

Introduction: Non-invasive ventilation may improve autonomic modulation and ventilatory parameters in severely disabled patients. The aim of the present study was to evaluate the physiological influence of acute treatment with different levels of continuous positive airway pressure (CPAP) on the autonomic balance of heart and respiratory responses in patients with stable chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF).

Materials and methods: A COPD group (n = 10), CHF group (n = 8) and healthy subjects (n = 10) were evaluated. The participants were randomized to receive three different levels of CPAP on the same day: sham ventilation (Sham), 5 cmH(2)0 (CPAP5) and 10 cmH(2)0 (CPAP10) for 10 min. Respiratory rate, end tidal carbon dioxide (E(T)CO(2)), peripheral oxygen saturation (SpO(2)), heart rate (HR), blood pressure and heart rate variability in the time and frequency domains were measured during spontaneous breathing and under the sham, CPAP5 and CPAP10 conditions.

Results: All groups experienced a reduction in E(T)CO(2) values during treatment with CPAP (p < 0.05). CPAP increased SpO(2) and HR in the COPD group (p < 0.05). The COPD group also had lower RMSSD values during treatment with different levels of CPAP when compared to the control group (p < 0.05). In the CHF group, CPAP5 and CPAP10 increased the SDNN value (p < 0.05). CPAP10 reduced the SDNN value in the COPD group (p < 0.05).

Conclusion: The findings suggest that CPAP may cause improvements in the neural control of heart rate in patients with stable COPD and CHF. For each patient, the "best CPAP level" should be defined as the best respiratory response and autonomic balance.

No MeSH data available.


Related in: MedlinePlus