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Hantavirus infections in humans and animals, China.

Zhang YZ, Zou Y, Fu ZF, Plyusnin A - Emerging Infect. Dis. (2010)

Bottom Line: After implementation of comprehensive preventive measures, including vaccination, in the past decade in China, incidence of HFRS has dramatically decreased; only 11,248 HFRS cases were reported in 2007.Mortality rates also declined from the highest level of 14.2% in 1969 to ?1% during 1995-2007.However, the numbers of HFRS cases and deaths in China remain the highest in the world.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory for Infectious Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
Hemorrhagic fever with renal syndrome (HFRS) is a serious public health problem in the People's Republic of China. Although 7 sero/genotypes of hantaviruses have been found in rodents, only Hantaan virus (carried by Apodemus agrarius mice) and Seoul virus (carried by Rattus norvegicus rats) reportedly cause disease in humans. During 1950-2007, a total of 1,557,622 cases of HFRS in humans and 46,427 deaths (3%) were reported in China. HFRS has been reported in 29 of 31 provinces in China. After implementation of comprehensive preventive measures, including vaccination, in the past decade in China, incidence of HFRS has dramatically decreased; only 11,248 HFRS cases were reported in 2007. Mortality rates also declined from the highest level of 14.2% in 1969 to ?1% during 1995-2007. However, the numbers of HFRS cases and deaths in China remain the highest in the world.

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Related in: MedlinePlus

Geographic distribution and annual incidence of hemorrhagic fever with renal syndrome in China in 1986 (A), 1996 (B), and 2006 (C).
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Figure 2: Geographic distribution and annual incidence of hemorrhagic fever with renal syndrome in China in 1986 (A), 1996 (B), and 2006 (C).

Mentions: Before 1950, HFRS cases had been reported in only 2 provinces (9), Heilongjiang and Jilin, which are located in northeastern China and share borders with Russia and North Korea, respectively. By the end of the 1950s, sporadic HFRS cases were reported in 8 provinces, spreading southward from northeastern to eastern and central China. By the end of the 1960s, HFRS cases were noted in 18 provinces; by the end of the 1970s, in 19 provinces; and during the 1980s and 1990s, in 27 and 28 provinces in southern and southwestern China, respectively. Especially after the discovery of SEOV in 1981 (15), HFRS distribution became nationwide; only 3 provinces (Qinghai, Xizang, and Xinjiang) remained unaffected (Figure 2). During 2000–2007, HFRS cases declined dramatically (Figure 2, panel C). Since 2005, however, 2 HFRS cases have been reported in Qinghai Province, where HFRS had never been found before; further studies are needed to clarify whether these 2 cases were indigenous or imported.


Hantavirus infections in humans and animals, China.

Zhang YZ, Zou Y, Fu ZF, Plyusnin A - Emerging Infect. Dis. (2010)

Geographic distribution and annual incidence of hemorrhagic fever with renal syndrome in China in 1986 (A), 1996 (B), and 2006 (C).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3298307&req=5

Figure 2: Geographic distribution and annual incidence of hemorrhagic fever with renal syndrome in China in 1986 (A), 1996 (B), and 2006 (C).
Mentions: Before 1950, HFRS cases had been reported in only 2 provinces (9), Heilongjiang and Jilin, which are located in northeastern China and share borders with Russia and North Korea, respectively. By the end of the 1950s, sporadic HFRS cases were reported in 8 provinces, spreading southward from northeastern to eastern and central China. By the end of the 1960s, HFRS cases were noted in 18 provinces; by the end of the 1970s, in 19 provinces; and during the 1980s and 1990s, in 27 and 28 provinces in southern and southwestern China, respectively. Especially after the discovery of SEOV in 1981 (15), HFRS distribution became nationwide; only 3 provinces (Qinghai, Xizang, and Xinjiang) remained unaffected (Figure 2). During 2000–2007, HFRS cases declined dramatically (Figure 2, panel C). Since 2005, however, 2 HFRS cases have been reported in Qinghai Province, where HFRS had never been found before; further studies are needed to clarify whether these 2 cases were indigenous or imported.

Bottom Line: After implementation of comprehensive preventive measures, including vaccination, in the past decade in China, incidence of HFRS has dramatically decreased; only 11,248 HFRS cases were reported in 2007.Mortality rates also declined from the highest level of 14.2% in 1969 to ?1% during 1995-2007.However, the numbers of HFRS cases and deaths in China remain the highest in the world.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory for Infectious Disease Control and Prevention, Beijing, People's Republic of China.

ABSTRACT
Hemorrhagic fever with renal syndrome (HFRS) is a serious public health problem in the People's Republic of China. Although 7 sero/genotypes of hantaviruses have been found in rodents, only Hantaan virus (carried by Apodemus agrarius mice) and Seoul virus (carried by Rattus norvegicus rats) reportedly cause disease in humans. During 1950-2007, a total of 1,557,622 cases of HFRS in humans and 46,427 deaths (3%) were reported in China. HFRS has been reported in 29 of 31 provinces in China. After implementation of comprehensive preventive measures, including vaccination, in the past decade in China, incidence of HFRS has dramatically decreased; only 11,248 HFRS cases were reported in 2007. Mortality rates also declined from the highest level of 14.2% in 1969 to ?1% during 1995-2007. However, the numbers of HFRS cases and deaths in China remain the highest in the world.

Show MeSH
Related in: MedlinePlus