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Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder.

Savitz J, Nugent AC, Cannon DM, Carlson PJ, Davis R, Neumeister A, Rallis-Frutos D, Fromm S, Herscovitch P, Drevets WC - Sci Rep (2012)

Bottom Line: A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD.The rCBF in the right amygdala was significantly correlated with depression severity.Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.

View Article: PubMed Central - PubMed

Affiliation: Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH/NIMH, Bethesda, MD. jonathansavitz@hotmail.com

ABSTRACT
Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [(15)O-H(2)O] positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDD patients and 62 HCs were scanned following arterial cannulation and 15 MDD patients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.

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Related in: MedlinePlus

Image sections from a statistical parametric map of voxel t-values which show regions where rCBF is significantly increased or decreased in contrasts A and C of the whole brain analysis.Stereotaxic coordinates are provided beneath each section, and are interpreted as described in the legend for figure 1. Abbreviations: A = anterior to anterior commissure, P = posterior to anterior commissure, L = left hemisphere, R = right hemisphere, spACC = supragenual ACC, pgACC = pregenual ACC, INS = insula, Tpolar C = temporopolar cortex, AMY = amygdala. Row A shows regions of the brain that show greater rCBF in MDDart+ versus MDDart- patients (contrast A). A1: sagittal slice showing increased rCBF to the supragenual and pregenual ACC (x = −2, y = 26, z = 24), A2: coronal slice showing increased rCBF to the temporopolar cortex, bilaterally (x = 22, y = 7, z = −21), A3: sagittal slice showing increased rCBF to the right postcentral gyrus (x = 59, y = −25, z = 34). Row B shows regions of the brain that demonstrate reduced flow in the MDDart+ group relative to the MDDart- group (contrast A). B1: coronal image showing decreased rCBF to the right dorsal anterior insula/frontal operculum (x = 36, y = −1, z = 15), B2: axial slice showing decreased rCBF to the anterior insula, bilaterally (x = 36, y = −1, z = 15), B3: axial image showing decreased rCBF to the right anterior insula (located dorsal and rostral to the cluster of voxels activated in B2 in the vicinity of the intrasulcal BA47s cortex20) (x = 26, y = 20, z = 6) in the MDDart+ group relative to the MDDart- group. Row C shows regions of the brain associated with greater rCBF in response to arterial cannulation in the MDD+ group compared with the MDDart- group relative to differences between the HCart+ and HCart- groups (contrast C). C1: axial slice showing increased rCBF to the left temporopolar cortex and right amygdala (see figure 1 legend and below for amygdala coordinates), C2: coronal slice showing increased rCBF to the left temporopolar cortex and right amygdala (x = 24, y = 3, z = −17), C3: axial slice showing increased rCBF to the postcentral gyrus (x = 58, y = −24, z = 34). A4, B4, and C4: Key showing correspondence between image color and voxel t-value.
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f2: Image sections from a statistical parametric map of voxel t-values which show regions where rCBF is significantly increased or decreased in contrasts A and C of the whole brain analysis.Stereotaxic coordinates are provided beneath each section, and are interpreted as described in the legend for figure 1. Abbreviations: A = anterior to anterior commissure, P = posterior to anterior commissure, L = left hemisphere, R = right hemisphere, spACC = supragenual ACC, pgACC = pregenual ACC, INS = insula, Tpolar C = temporopolar cortex, AMY = amygdala. Row A shows regions of the brain that show greater rCBF in MDDart+ versus MDDart- patients (contrast A). A1: sagittal slice showing increased rCBF to the supragenual and pregenual ACC (x = −2, y = 26, z = 24), A2: coronal slice showing increased rCBF to the temporopolar cortex, bilaterally (x = 22, y = 7, z = −21), A3: sagittal slice showing increased rCBF to the right postcentral gyrus (x = 59, y = −25, z = 34). Row B shows regions of the brain that demonstrate reduced flow in the MDDart+ group relative to the MDDart- group (contrast A). B1: coronal image showing decreased rCBF to the right dorsal anterior insula/frontal operculum (x = 36, y = −1, z = 15), B2: axial slice showing decreased rCBF to the anterior insula, bilaterally (x = 36, y = −1, z = 15), B3: axial image showing decreased rCBF to the right anterior insula (located dorsal and rostral to the cluster of voxels activated in B2 in the vicinity of the intrasulcal BA47s cortex20) (x = 26, y = 20, z = 6) in the MDDart+ group relative to the MDDart- group. Row C shows regions of the brain associated with greater rCBF in response to arterial cannulation in the MDD+ group compared with the MDDart- group relative to differences between the HCart+ and HCart- groups (contrast C). C1: axial slice showing increased rCBF to the left temporopolar cortex and right amygdala (see figure 1 legend and below for amygdala coordinates), C2: coronal slice showing increased rCBF to the left temporopolar cortex and right amygdala (x = 24, y = 3, z = −17), C3: axial slice showing increased rCBF to the postcentral gyrus (x = 58, y = −24, z = 34). A4, B4, and C4: Key showing correspondence between image color and voxel t-value.

Mentions: Regions in which MDDart+ patients showed increased rCBF compared with MDDart- participants included (table 5 and fig. 2A): the supragenual and pregenual ACC, right entorhinal cortex, temporopolar cortex bilaterally, rostral temporal sulcal cortex (junction of superior and middle temporal gyri) bilaterally, ventromedial PFC, left ventrolateral PFC, left lateral orbitofrontal PFC, postcentral gyri and adjacent inferior parietal cortex bilaterally, and precuneus.


Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder.

Savitz J, Nugent AC, Cannon DM, Carlson PJ, Davis R, Neumeister A, Rallis-Frutos D, Fromm S, Herscovitch P, Drevets WC - Sci Rep (2012)

Image sections from a statistical parametric map of voxel t-values which show regions where rCBF is significantly increased or decreased in contrasts A and C of the whole brain analysis.Stereotaxic coordinates are provided beneath each section, and are interpreted as described in the legend for figure 1. Abbreviations: A = anterior to anterior commissure, P = posterior to anterior commissure, L = left hemisphere, R = right hemisphere, spACC = supragenual ACC, pgACC = pregenual ACC, INS = insula, Tpolar C = temporopolar cortex, AMY = amygdala. Row A shows regions of the brain that show greater rCBF in MDDart+ versus MDDart- patients (contrast A). A1: sagittal slice showing increased rCBF to the supragenual and pregenual ACC (x = −2, y = 26, z = 24), A2: coronal slice showing increased rCBF to the temporopolar cortex, bilaterally (x = 22, y = 7, z = −21), A3: sagittal slice showing increased rCBF to the right postcentral gyrus (x = 59, y = −25, z = 34). Row B shows regions of the brain that demonstrate reduced flow in the MDDart+ group relative to the MDDart- group (contrast A). B1: coronal image showing decreased rCBF to the right dorsal anterior insula/frontal operculum (x = 36, y = −1, z = 15), B2: axial slice showing decreased rCBF to the anterior insula, bilaterally (x = 36, y = −1, z = 15), B3: axial image showing decreased rCBF to the right anterior insula (located dorsal and rostral to the cluster of voxels activated in B2 in the vicinity of the intrasulcal BA47s cortex20) (x = 26, y = 20, z = 6) in the MDDart+ group relative to the MDDart- group. Row C shows regions of the brain associated with greater rCBF in response to arterial cannulation in the MDD+ group compared with the MDDart- group relative to differences between the HCart+ and HCart- groups (contrast C). C1: axial slice showing increased rCBF to the left temporopolar cortex and right amygdala (see figure 1 legend and below for amygdala coordinates), C2: coronal slice showing increased rCBF to the left temporopolar cortex and right amygdala (x = 24, y = 3, z = −17), C3: axial slice showing increased rCBF to the postcentral gyrus (x = 58, y = −24, z = 34). A4, B4, and C4: Key showing correspondence between image color and voxel t-value.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3297085&req=5

f2: Image sections from a statistical parametric map of voxel t-values which show regions where rCBF is significantly increased or decreased in contrasts A and C of the whole brain analysis.Stereotaxic coordinates are provided beneath each section, and are interpreted as described in the legend for figure 1. Abbreviations: A = anterior to anterior commissure, P = posterior to anterior commissure, L = left hemisphere, R = right hemisphere, spACC = supragenual ACC, pgACC = pregenual ACC, INS = insula, Tpolar C = temporopolar cortex, AMY = amygdala. Row A shows regions of the brain that show greater rCBF in MDDart+ versus MDDart- patients (contrast A). A1: sagittal slice showing increased rCBF to the supragenual and pregenual ACC (x = −2, y = 26, z = 24), A2: coronal slice showing increased rCBF to the temporopolar cortex, bilaterally (x = 22, y = 7, z = −21), A3: sagittal slice showing increased rCBF to the right postcentral gyrus (x = 59, y = −25, z = 34). Row B shows regions of the brain that demonstrate reduced flow in the MDDart+ group relative to the MDDart- group (contrast A). B1: coronal image showing decreased rCBF to the right dorsal anterior insula/frontal operculum (x = 36, y = −1, z = 15), B2: axial slice showing decreased rCBF to the anterior insula, bilaterally (x = 36, y = −1, z = 15), B3: axial image showing decreased rCBF to the right anterior insula (located dorsal and rostral to the cluster of voxels activated in B2 in the vicinity of the intrasulcal BA47s cortex20) (x = 26, y = 20, z = 6) in the MDDart+ group relative to the MDDart- group. Row C shows regions of the brain associated with greater rCBF in response to arterial cannulation in the MDD+ group compared with the MDDart- group relative to differences between the HCart+ and HCart- groups (contrast C). C1: axial slice showing increased rCBF to the left temporopolar cortex and right amygdala (see figure 1 legend and below for amygdala coordinates), C2: coronal slice showing increased rCBF to the left temporopolar cortex and right amygdala (x = 24, y = 3, z = −17), C3: axial slice showing increased rCBF to the postcentral gyrus (x = 58, y = −24, z = 34). A4, B4, and C4: Key showing correspondence between image color and voxel t-value.
Mentions: Regions in which MDDart+ patients showed increased rCBF compared with MDDart- participants included (table 5 and fig. 2A): the supragenual and pregenual ACC, right entorhinal cortex, temporopolar cortex bilaterally, rostral temporal sulcal cortex (junction of superior and middle temporal gyri) bilaterally, ventromedial PFC, left ventrolateral PFC, left lateral orbitofrontal PFC, postcentral gyri and adjacent inferior parietal cortex bilaterally, and precuneus.

Bottom Line: A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD.The rCBF in the right amygdala was significantly correlated with depression severity.Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.

View Article: PubMed Central - PubMed

Affiliation: Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH/NIMH, Bethesda, MD. jonathansavitz@hotmail.com

ABSTRACT
Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [(15)O-H(2)O] positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDD patients and 62 HCs were scanned following arterial cannulation and 15 MDD patients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.

Show MeSH
Related in: MedlinePlus