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Evaluation of serial C-reactive protein measurements after surgical treatment of pleural empyema.

Medeiros IL, Terra RM, Choi EM, Pego-Fernandes PM, Jatene FB - Clinics (Sao Paulo) (2012)

Bottom Line: The median C-reactive protein values were as follows: 146 mg/L (pre-operative), 134 mg/L (post-operative day 2), and 116 mg/L (post-operative day 7).There was a trend toward a decrease in these values during the first week after surgery, but this difference was only statistically significant on day 7 after surgery.Over the first week after surgery, the C-reactive protein values decreased similarly in both groups (successful and failed treatment).

View Article: PubMed Central - PubMed

Affiliation: Messejana Hospital, Fortaleza, CE, Brazil.

ABSTRACT

Objective: Serial C-reactive protein measurements have been used to diagnose and monitor the response to therapy in patients with pneumonia and other infectious diseases. Nonetheless, the role of C-reactive protein measurement after surgical treatment for pleural empyema is not well defined. The aim of this study is to describe the behavior of C-reactive protein levels after the surgical treatment of pleural empyema and to correlate this parameter with the patient's prognosis.

Methods: We retrospectively analyzed the records of patients with pleural empyema treated by either chest-tube drainage or surgery from January 2006 to December 2008. C-reactive protein levels were recorded preoperatively and 2 and 7 days postoperatively. The clinical outcome was binary: success or failure (mortality or the need for repeated pleural intervention).

Results: The study group comprised fifty-two patients. The median C-reactive protein values were as follows: 146 mg/L (pre-operative), 134 mg/L (post-operative day 2), and 116 mg/L (post-operative day 7). There was a trend toward a decrease in these values during the first week after surgery, but this difference was only statistically significant on day 7 after surgery. Over the first week after surgery, the C-reactive protein values decreased similarly in both groups (successful and failed treatment). No correlation between the preoperative C-reactive protein level and the clinical outcome was found.

Conclusions: We observed that, in contrast to other medical conditions, C-reactive protein levels fall slowly during the first postoperative week in patients who have undergone surgical treatment for pleural empyema. No correlation between the perioperative C-reactive protein level and the clinical outcome was observed.

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Related in: MedlinePlus

The CRP pattern of change according to outcome.
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Related In: Results  -  Collection

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f2-cln_67p243: The CRP pattern of change according to outcome.

Mentions: We divided the patients into two groups: successful treatment (69.2%) and failure (30.8%). Over the first week after surgery, the CRP values decreased to a similar extent in both groups (pā€Š=ā€Š0.64; Figure 2). The CRP values and WBC of success and failure groups were not significantly different before surgery or at postoperative days 2 and 7 (Table 2).


Evaluation of serial C-reactive protein measurements after surgical treatment of pleural empyema.

Medeiros IL, Terra RM, Choi EM, Pego-Fernandes PM, Jatene FB - Clinics (Sao Paulo) (2012)

The CRP pattern of change according to outcome.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3297033&req=5

f2-cln_67p243: The CRP pattern of change according to outcome.
Mentions: We divided the patients into two groups: successful treatment (69.2%) and failure (30.8%). Over the first week after surgery, the CRP values decreased to a similar extent in both groups (pā€Š=ā€Š0.64; Figure 2). The CRP values and WBC of success and failure groups were not significantly different before surgery or at postoperative days 2 and 7 (Table 2).

Bottom Line: The median C-reactive protein values were as follows: 146 mg/L (pre-operative), 134 mg/L (post-operative day 2), and 116 mg/L (post-operative day 7).There was a trend toward a decrease in these values during the first week after surgery, but this difference was only statistically significant on day 7 after surgery.Over the first week after surgery, the C-reactive protein values decreased similarly in both groups (successful and failed treatment).

View Article: PubMed Central - PubMed

Affiliation: Messejana Hospital, Fortaleza, CE, Brazil.

ABSTRACT

Objective: Serial C-reactive protein measurements have been used to diagnose and monitor the response to therapy in patients with pneumonia and other infectious diseases. Nonetheless, the role of C-reactive protein measurement after surgical treatment for pleural empyema is not well defined. The aim of this study is to describe the behavior of C-reactive protein levels after the surgical treatment of pleural empyema and to correlate this parameter with the patient's prognosis.

Methods: We retrospectively analyzed the records of patients with pleural empyema treated by either chest-tube drainage or surgery from January 2006 to December 2008. C-reactive protein levels were recorded preoperatively and 2 and 7 days postoperatively. The clinical outcome was binary: success or failure (mortality or the need for repeated pleural intervention).

Results: The study group comprised fifty-two patients. The median C-reactive protein values were as follows: 146 mg/L (pre-operative), 134 mg/L (post-operative day 2), and 116 mg/L (post-operative day 7). There was a trend toward a decrease in these values during the first week after surgery, but this difference was only statistically significant on day 7 after surgery. Over the first week after surgery, the C-reactive protein values decreased similarly in both groups (successful and failed treatment). No correlation between the preoperative C-reactive protein level and the clinical outcome was found.

Conclusions: We observed that, in contrast to other medical conditions, C-reactive protein levels fall slowly during the first postoperative week in patients who have undergone surgical treatment for pleural empyema. No correlation between the perioperative C-reactive protein level and the clinical outcome was observed.

Show MeSH
Related in: MedlinePlus