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Positive result in the early passive phase of the tilt-table test: a predictor of neurocardiogenic syncope in young men.

Uhm JS, Youn HJ, Chung WB, Choi YS, Park CS, Oh YS, Chung WS, Park KI, Kim TS - Korean J. Intern. Med. (2012)

Bottom Line: The subjects with positive results were followed without medication.The frequency of previous syncopal episodes ≥ 4 (p = 0.001) and a positive result during the passive phase (p = 0.022) were significantly related to a high recurrence rate.A positive result during the early passive phase (≤ 12 minutes) was significantly related to a higher recurrence rate than was that during the late passive phase (> 12 minutes; p = 0.011).

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.

ABSTRACT

Background/aims: This study elucidated the prognostic factors for neurocardiogenic syncope in males in their late teens and early twenties.

Methods: Tilt-table testing (TTT) was performed on 665 males (age range, 17 to 27 years) following the Italian protocol. The subjects were tilted head-up at a 70° angle on a table for 30 minutes during the passive phase. If the passive phase was negative, the subjects were given sublingual nitroglycerin and tilted to the same angle for 20 minutes during the drug-provocation phase. The subjects with positive results were followed without medication. We analyzed factors related to the recurrence rate of syncope.

Results: Of 305 subjects (45.8%) with positive results, 223 (age range, 18 to 26 years) were followed for 12 months. The frequency of previous syncopal episodes ≥ 4 (p = 0.001) and a positive result during the passive phase (p = 0.022) were significantly related to a high recurrence rate. A positive result during the early passive phase (≤ 12 minutes) was significantly related to a higher recurrence rate than was that during the late passive phase (> 12 minutes; p = 0.011).

Conclusions: A positive result during the early passive phase of TTT and frequent previous syncopal episodes were prognostic factors for neurocardiogenic syncope in men in their late teens and early twenties.

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Related in: MedlinePlus

Flow diagram and number of subjects. Eighty-two patients were excluded because they were lost to follow-up or because they took medicine.
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Figure 1: Flow diagram and number of subjects. Eighty-two patients were excluded because they were lost to follow-up or because they took medicine.

Mentions: Of the 665 male subjects (mean age, 22.0 years; range, 17 to 27) who underwent testing, 305 (45.8%) had positive results on TTT. Of the subjects with positive results, 82 were excluded because of abnormal ECGs or loss to follow-up (Fig. 1). We followed 223 subjects (mean age, 21.1 years; range, 18 to 26) for 12 months. The frequency of previous syncopal episodes was 3.4 ± 5.0 (Table 1).


Positive result in the early passive phase of the tilt-table test: a predictor of neurocardiogenic syncope in young men.

Uhm JS, Youn HJ, Chung WB, Choi YS, Park CS, Oh YS, Chung WS, Park KI, Kim TS - Korean J. Intern. Med. (2012)

Flow diagram and number of subjects. Eighty-two patients were excluded because they were lost to follow-up or because they took medicine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3295990&req=5

Figure 1: Flow diagram and number of subjects. Eighty-two patients were excluded because they were lost to follow-up or because they took medicine.
Mentions: Of the 665 male subjects (mean age, 22.0 years; range, 17 to 27) who underwent testing, 305 (45.8%) had positive results on TTT. Of the subjects with positive results, 82 were excluded because of abnormal ECGs or loss to follow-up (Fig. 1). We followed 223 subjects (mean age, 21.1 years; range, 18 to 26) for 12 months. The frequency of previous syncopal episodes was 3.4 ± 5.0 (Table 1).

Bottom Line: The subjects with positive results were followed without medication.The frequency of previous syncopal episodes ≥ 4 (p = 0.001) and a positive result during the passive phase (p = 0.022) were significantly related to a high recurrence rate.A positive result during the early passive phase (≤ 12 minutes) was significantly related to a higher recurrence rate than was that during the late passive phase (> 12 minutes; p = 0.011).

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea.

ABSTRACT

Background/aims: This study elucidated the prognostic factors for neurocardiogenic syncope in males in their late teens and early twenties.

Methods: Tilt-table testing (TTT) was performed on 665 males (age range, 17 to 27 years) following the Italian protocol. The subjects were tilted head-up at a 70° angle on a table for 30 minutes during the passive phase. If the passive phase was negative, the subjects were given sublingual nitroglycerin and tilted to the same angle for 20 minutes during the drug-provocation phase. The subjects with positive results were followed without medication. We analyzed factors related to the recurrence rate of syncope.

Results: Of 305 subjects (45.8%) with positive results, 223 (age range, 18 to 26 years) were followed for 12 months. The frequency of previous syncopal episodes ≥ 4 (p = 0.001) and a positive result during the passive phase (p = 0.022) were significantly related to a high recurrence rate. A positive result during the early passive phase (≤ 12 minutes) was significantly related to a higher recurrence rate than was that during the late passive phase (> 12 minutes; p = 0.011).

Conclusions: A positive result during the early passive phase of TTT and frequent previous syncopal episodes were prognostic factors for neurocardiogenic syncope in men in their late teens and early twenties.

Show MeSH
Related in: MedlinePlus