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The burden of trachoma in South Sudan: assessing the health losses from a condition of graded severity.

Gouda H, Powles J, Barendregt J, Emerson P, Ngondi J - PLoS Negl Trop Dis (2012)

Bottom Line: Different assumptions about disability weights and duration were used to estimate the Years Lived with Disability (YLD).Women experience more of this burden than men.The sensitivity of the results to different assumptions about the disability weights is partly dependent upon the assumed duration of the different disease states.

View Article: PubMed Central - PubMed

Affiliation: Institute of Public Health, University of Cambridge, Cambridge, United Kingdom. h.gouda@uq.edu.au

ABSTRACT

Introduction: Trachoma is a disease that can lead to visual impairment and ultimately blindness. Previous estimates of health losses from trachoma using the Global Burden of Disease methodology have not, however, included the stage prior to visual impairment. We estimated the burden of all stages of trachoma in South Sudan and assessed the uncertainty associated with the severity and duration of stages of trachoma prior to full blindness.

Methods: The prevalence of trachoma with normal vision, low vision and blindness in the Republic of South Sudan has been estimated previously. These estimates were used to model the incidence and duration of the different stages employing DISMOD II. Different assumptions about disability weights and duration were used to estimate the Years Lived with Disability (YLD).

Results: We have estimated the total burden of trachoma in South Sudan to be between 136,562 and 163,695 YLD and trichiasis with normal vision contributes between 5% and 21% of the total depending on the disability weight applied. Women experience more of this burden than men. The sensitivity of the results to different assumptions about the disability weights is partly dependent upon the assumed duration of the different disease states.

Interpretation: A better understanding of the natural history of trachoma is critical for a more accurate burden estimate.

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Related in: MedlinePlus

YLDs (3,1) lost due to trichiasis by age in South Sudan.
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pntd-0001538-g002: YLDs (3,1) lost due to trichiasis by age in South Sudan.

Mentions: Most of the burden associated with trichiasis with normal vision is experienced during childhood and while the burden of trichiasis with low vision is placed upon young adults and blindness is mostly experienced in later life (Figure 2). Age weighting emphasizes the contribution of trichiasis with normal and low vision on the total burden of trachoma (Figure 1).


The burden of trachoma in South Sudan: assessing the health losses from a condition of graded severity.

Gouda H, Powles J, Barendregt J, Emerson P, Ngondi J - PLoS Negl Trop Dis (2012)

YLDs (3,1) lost due to trichiasis by age in South Sudan.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3295813&req=5

pntd-0001538-g002: YLDs (3,1) lost due to trichiasis by age in South Sudan.
Mentions: Most of the burden associated with trichiasis with normal vision is experienced during childhood and while the burden of trichiasis with low vision is placed upon young adults and blindness is mostly experienced in later life (Figure 2). Age weighting emphasizes the contribution of trichiasis with normal and low vision on the total burden of trachoma (Figure 1).

Bottom Line: Different assumptions about disability weights and duration were used to estimate the Years Lived with Disability (YLD).Women experience more of this burden than men.The sensitivity of the results to different assumptions about the disability weights is partly dependent upon the assumed duration of the different disease states.

View Article: PubMed Central - PubMed

Affiliation: Institute of Public Health, University of Cambridge, Cambridge, United Kingdom. h.gouda@uq.edu.au

ABSTRACT

Introduction: Trachoma is a disease that can lead to visual impairment and ultimately blindness. Previous estimates of health losses from trachoma using the Global Burden of Disease methodology have not, however, included the stage prior to visual impairment. We estimated the burden of all stages of trachoma in South Sudan and assessed the uncertainty associated with the severity and duration of stages of trachoma prior to full blindness.

Methods: The prevalence of trachoma with normal vision, low vision and blindness in the Republic of South Sudan has been estimated previously. These estimates were used to model the incidence and duration of the different stages employing DISMOD II. Different assumptions about disability weights and duration were used to estimate the Years Lived with Disability (YLD).

Results: We have estimated the total burden of trachoma in South Sudan to be between 136,562 and 163,695 YLD and trichiasis with normal vision contributes between 5% and 21% of the total depending on the disability weight applied. Women experience more of this burden than men. The sensitivity of the results to different assumptions about the disability weights is partly dependent upon the assumed duration of the different disease states.

Interpretation: A better understanding of the natural history of trachoma is critical for a more accurate burden estimate.

Show MeSH
Related in: MedlinePlus