Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.
Bottom Line: Cerebral malaria, a severe form of Plasmodium falciparum infection, is an important cause of mortality in sub-Saharan African children.Children with retinopathy-positive cerebral malaria had significantly less complex infections than those without retinopathy (OR = 3.7, 95% CI [1.51-9.10]).The complexity of infections significantly decreased over the malaria season in retinopathy-positive patients compared to retinopathy-negative patients.Limited diversity in the peripheral blood of cerebral malaria patients and correlation with tissues supports peripheral blood samples as appropriate for genome-wide association studies of parasite determinants of pathogenicity.
Affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Amory 3, Boston, MA 02115, USA. email@example.comShow MeSH
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Mentions: The complexity of infections in both patient groups decreased over the six months during which data were collected (i.e. from start to end of the malaria season). Retinopathy-positive CM patients had consistently and significantly fewer heterozygous calls per patient (p-value = 0.00007, Figure 4) than retinopathy-negative patients, throughout the period of study.
Affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Amory 3, Boston, MA 02115, USA. firstname.lastname@example.org