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Fluoride bioavailability in saliva and plaque.

Naumova EA, Kuehnl P, Hertenstein P, Markovic L, Jordan RA, Gaengler P, Arnold WH - BMC Oral Health (2012)

Bottom Line: Different fluoride formulations may have different effects on caries prevention.No difference was found between NaF and amine fluoride.However, no significant difference in bioavailability between NaF and amine fluoride, in saliva, or in plaque was found.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Health, Department of Dentistry, University of Witten/Herdecke, Alfred Herrhausenstrasse 50, 58448 Witten, Germany.

ABSTRACT

Background: Different fluoride formulations may have different effects on caries prevention. It was the aim of this clinical study to assess the fluoride content, provided by NaF compared to amine fluoride, in saliva and plaque.

Methods: Eight trained volunteers brushed their teeth in the morning for 3 minutes with either NaF or amine fluoride, and saliva and 3-day-plaque-regrowth was collected at 5 time intervals during 6 hours after tooth brushing. The amount of collected saliva and plaque was measured, and the fluoride content was analysed using a fluoride sensitive electrode. All subjects repeated all study cycles 5 times, and 3 cycles per subject underwent statistical analysis using the Wilcoxon-Mann-Whitney test.

Results: Immediately after brushing the fluoride concentration in saliva increased rapidly and dropped to the baseline level after 360 minutes. No difference was found between NaF and amine fluoride. All plaque fluoride levels were elevated after 30 minutes until 120 minutes after tooth brushing, and decreasing after 360 minutes to baseline. According to the highly individual profile of fluoride in saliva and plaque, both levels of bioavailability correlated for the first 30 minutes, and the fluoride content of saliva and plaque was back to baseline after 6 hours.

Conclusions: Fluoride levels in saliva and plaque are interindividually highly variable. However, no significant difference in bioavailability between NaF and amine fluoride, in saliva, or in plaque was found.

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Related in: MedlinePlus

Fluoride content in plaque. Fluoride content in plaque after brushing with NaF or amine fluoride. The fluoride content in plaque is increasing 30 and 120 minutes after using NaF or amine fluoride and dropping to baseline level after 360 minutes. The differences are not significant.
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Figure 3: Fluoride content in plaque. Fluoride content in plaque after brushing with NaF or amine fluoride. The fluoride content in plaque is increasing 30 and 120 minutes after using NaF or amine fluoride and dropping to baseline level after 360 minutes. The differences are not significant.

Mentions: The fluoride content in plaque increased 30 minutes after tooth brushing, but the increase was not significant (p = 0.152). The range of the NaF arm was 3 to 1063 ppm, and for the amine fluoride arm was 24.3 to 1201 ppm fluoride. Between 30 minutes and 2 hours the fluoride content within plaque decreased slightly and after 6 hours the fluoride content in plaque was close to the baseline level with no significant differences (Figure 3). Six hours after tooth brushing the mean fluoride content in plaque and the high intraindividual and interindividual range represented the baseline levels with no statistical differences (Figure 4)


Fluoride bioavailability in saliva and plaque.

Naumova EA, Kuehnl P, Hertenstein P, Markovic L, Jordan RA, Gaengler P, Arnold WH - BMC Oral Health (2012)

Fluoride content in plaque. Fluoride content in plaque after brushing with NaF or amine fluoride. The fluoride content in plaque is increasing 30 and 120 minutes after using NaF or amine fluoride and dropping to baseline level after 360 minutes. The differences are not significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3295678&req=5

Figure 3: Fluoride content in plaque. Fluoride content in plaque after brushing with NaF or amine fluoride. The fluoride content in plaque is increasing 30 and 120 minutes after using NaF or amine fluoride and dropping to baseline level after 360 minutes. The differences are not significant.
Mentions: The fluoride content in plaque increased 30 minutes after tooth brushing, but the increase was not significant (p = 0.152). The range of the NaF arm was 3 to 1063 ppm, and for the amine fluoride arm was 24.3 to 1201 ppm fluoride. Between 30 minutes and 2 hours the fluoride content within plaque decreased slightly and after 6 hours the fluoride content in plaque was close to the baseline level with no significant differences (Figure 3). Six hours after tooth brushing the mean fluoride content in plaque and the high intraindividual and interindividual range represented the baseline levels with no statistical differences (Figure 4)

Bottom Line: Different fluoride formulations may have different effects on caries prevention.No difference was found between NaF and amine fluoride.However, no significant difference in bioavailability between NaF and amine fluoride, in saliva, or in plaque was found.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Health, Department of Dentistry, University of Witten/Herdecke, Alfred Herrhausenstrasse 50, 58448 Witten, Germany.

ABSTRACT

Background: Different fluoride formulations may have different effects on caries prevention. It was the aim of this clinical study to assess the fluoride content, provided by NaF compared to amine fluoride, in saliva and plaque.

Methods: Eight trained volunteers brushed their teeth in the morning for 3 minutes with either NaF or amine fluoride, and saliva and 3-day-plaque-regrowth was collected at 5 time intervals during 6 hours after tooth brushing. The amount of collected saliva and plaque was measured, and the fluoride content was analysed using a fluoride sensitive electrode. All subjects repeated all study cycles 5 times, and 3 cycles per subject underwent statistical analysis using the Wilcoxon-Mann-Whitney test.

Results: Immediately after brushing the fluoride concentration in saliva increased rapidly and dropped to the baseline level after 360 minutes. No difference was found between NaF and amine fluoride. All plaque fluoride levels were elevated after 30 minutes until 120 minutes after tooth brushing, and decreasing after 360 minutes to baseline. According to the highly individual profile of fluoride in saliva and plaque, both levels of bioavailability correlated for the first 30 minutes, and the fluoride content of saliva and plaque was back to baseline after 6 hours.

Conclusions: Fluoride levels in saliva and plaque are interindividually highly variable. However, no significant difference in bioavailability between NaF and amine fluoride, in saliva, or in plaque was found.

Show MeSH
Related in: MedlinePlus