Limits...
Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system.

Worsøe J, Fynne L, Gregersen T, Schlageter V, Christensen LA, Dahlerup JF, Rijkhoff NJ, Laurberg S, Krogh K - BMC Gastroenterol (2011)

Bottom Line: Comparing experiments (1) and (2) there were no systematic differences in gastric transit or small intestinal transit when using the magnet-PillCam unit and the much smaller magnetic pill.In experiments (2) and (3), short bursts of very fast movements lasting less than 5% of the time accounted for more than half the distance covered during the first two hours in the small intestine, irrespective of whether the small intestine was in the fasting or postprandial state.MTS-1 is reliable for determination of gastric transit and small intestinal transit time.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark. jonas.worsoe@gmail.com

ABSTRACT

Background: Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal transit. The aim was to test the validity of MTS-1 for assessment of gastric transit time and small intestinal transit time, and to illustrate transit patterns detected by the system.

Methods: A small magnet was ingested and tracked by an external matrix of 16 magnetic field sensors (4 × 4) giving a position defined by 5 coordinates (position: x, y, z, and angle: θ, φ). Eight healthy subjects were each investigated three times: (1) with a small magnet mounted on a capsule endoscope (PillCam); (2) with the magnet alone and the small intestine in the fasting state; and (3) with the magnet alone and the small intestine in the postprandial state.

Results: Experiment (1) showed good agreement and no systematic differences between MTS-1 and capsule endoscopy when assessing gastric transit (median difference 1 min; range: 0-6 min) and small intestinal transit time (median difference 0.5 min; range: 0-52 min). Comparing experiments (1) and (2) there were no systematic differences in gastric transit or small intestinal transit when using the magnet-PillCam unit and the much smaller magnetic pill. In experiments (2) and (3), short bursts of very fast movements lasting less than 5% of the time accounted for more than half the distance covered during the first two hours in the small intestine, irrespective of whether the small intestine was in the fasting or postprandial state. The mean contraction frequency in the small intestine was significantly lower in the fasting state than in the postprandial state (9.90 min-1 vs. 10.53 min-1) (p = 0.03).

Conclusion: MTS-1 is reliable for determination of gastric transit and small intestinal transit time. It is possible to distinguish between the mean contraction frequency of small intestine in the fasting state and in the postprandial state.

Show MeSH

Related in: MedlinePlus

Correlation of anatomical data and motility data using the PillCam and the Magnet Tracking System, Left: image from the stomach with simultaneous MTS-1 data (orientation θ and ϕ on the y-axis) showing a contraction frequency of approximately 3 min-1 (arbitrary unit), consistent with localization in the stomach. Right: image from the proximal small intestine with simultaneous MTS-1 data showing a contraction frequency of approximately 9-10 min-1 (arbitrary unit) consistent with localization in the small intestine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3295650&req=5

Figure 2: Correlation of anatomical data and motility data using the PillCam and the Magnet Tracking System, Left: image from the stomach with simultaneous MTS-1 data (orientation θ and ϕ on the y-axis) showing a contraction frequency of approximately 3 min-1 (arbitrary unit), consistent with localization in the stomach. Right: image from the proximal small intestine with simultaneous MTS-1 data showing a contraction frequency of approximately 9-10 min-1 (arbitrary unit) consistent with localization in the small intestine.

Mentions: The validity of gastric transit and small intestinal transit determined with MTS-1 was tested through comparison with the simultaneous use of a PillCam (Figure 2). The video capsule (PillCam, Given, Yoqnaem, Israel) measures 11 × 26 mm and contains an imaging device (field of view of 156°) and a light source at one end of the capsule [34]. Images were transmitted at a rate of two images s-1 with a battery powered light source lasting for a minimum of eight hours.


Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system.

Worsøe J, Fynne L, Gregersen T, Schlageter V, Christensen LA, Dahlerup JF, Rijkhoff NJ, Laurberg S, Krogh K - BMC Gastroenterol (2011)

Correlation of anatomical data and motility data using the PillCam and the Magnet Tracking System, Left: image from the stomach with simultaneous MTS-1 data (orientation θ and ϕ on the y-axis) showing a contraction frequency of approximately 3 min-1 (arbitrary unit), consistent with localization in the stomach. Right: image from the proximal small intestine with simultaneous MTS-1 data showing a contraction frequency of approximately 9-10 min-1 (arbitrary unit) consistent with localization in the small intestine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3295650&req=5

Figure 2: Correlation of anatomical data and motility data using the PillCam and the Magnet Tracking System, Left: image from the stomach with simultaneous MTS-1 data (orientation θ and ϕ on the y-axis) showing a contraction frequency of approximately 3 min-1 (arbitrary unit), consistent with localization in the stomach. Right: image from the proximal small intestine with simultaneous MTS-1 data showing a contraction frequency of approximately 9-10 min-1 (arbitrary unit) consistent with localization in the small intestine.
Mentions: The validity of gastric transit and small intestinal transit determined with MTS-1 was tested through comparison with the simultaneous use of a PillCam (Figure 2). The video capsule (PillCam, Given, Yoqnaem, Israel) measures 11 × 26 mm and contains an imaging device (field of view of 156°) and a light source at one end of the capsule [34]. Images were transmitted at a rate of two images s-1 with a battery powered light source lasting for a minimum of eight hours.

Bottom Line: Comparing experiments (1) and (2) there were no systematic differences in gastric transit or small intestinal transit when using the magnet-PillCam unit and the much smaller magnetic pill.In experiments (2) and (3), short bursts of very fast movements lasting less than 5% of the time accounted for more than half the distance covered during the first two hours in the small intestine, irrespective of whether the small intestine was in the fasting or postprandial state.MTS-1 is reliable for determination of gastric transit and small intestinal transit time.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark. jonas.worsoe@gmail.com

ABSTRACT

Background: Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal transit. The aim was to test the validity of MTS-1 for assessment of gastric transit time and small intestinal transit time, and to illustrate transit patterns detected by the system.

Methods: A small magnet was ingested and tracked by an external matrix of 16 magnetic field sensors (4 × 4) giving a position defined by 5 coordinates (position: x, y, z, and angle: θ, φ). Eight healthy subjects were each investigated three times: (1) with a small magnet mounted on a capsule endoscope (PillCam); (2) with the magnet alone and the small intestine in the fasting state; and (3) with the magnet alone and the small intestine in the postprandial state.

Results: Experiment (1) showed good agreement and no systematic differences between MTS-1 and capsule endoscopy when assessing gastric transit (median difference 1 min; range: 0-6 min) and small intestinal transit time (median difference 0.5 min; range: 0-52 min). Comparing experiments (1) and (2) there were no systematic differences in gastric transit or small intestinal transit when using the magnet-PillCam unit and the much smaller magnetic pill. In experiments (2) and (3), short bursts of very fast movements lasting less than 5% of the time accounted for more than half the distance covered during the first two hours in the small intestine, irrespective of whether the small intestine was in the fasting or postprandial state. The mean contraction frequency in the small intestine was significantly lower in the fasting state than in the postprandial state (9.90 min-1 vs. 10.53 min-1) (p = 0.03).

Conclusion: MTS-1 is reliable for determination of gastric transit and small intestinal transit time. It is possible to distinguish between the mean contraction frequency of small intestine in the fasting state and in the postprandial state.

Show MeSH
Related in: MedlinePlus