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Association between a Primitive Brain Tumor and Cerebral Aspergillosis.

Hélage S, Duyckaerts C, Seilhean D, Hauw JJ, Chiras J - Case Rep Med (2012)

Bottom Line: This infection of the central nervous system is generally the complication of an invasive aspergillosis with hematogenic scattering from pulmonary focal spots.It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer.Clinicopathological aspects and therapeutic approach are described.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire de Neuropathologie Escourolle, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47-83 boulevard de l'Hôpital, 75651 Paris cedex 13, France.

ABSTRACT
Cerebral aspergillosis is a rare pathology of poor prognosis in spite of the use of adapted antifungal treatments. This infection of the central nervous system is generally the complication of an invasive aspergillosis with hematogenic scattering from pulmonary focal spots. It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer. A case of lethal cerebral aspergillosis in a patient with an infiltrative glioma treated with corticotherapy and radiotherapy is reported. Clinicopathological aspects and therapeutic approach are described.

No MeSH data available.


Related in: MedlinePlus

Autopsic brain coronal section. Right thalamus and corona radiata abscessed hemorrhagic infarcts.
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fig2: Autopsic brain coronal section. Right thalamus and corona radiata abscessed hemorrhagic infarcts.

Mentions: on the infectious side, there were abscesses of both superior pulmonary lobes. The microscopic examination brought to light aspergillar abscesses with branched out Grocott-positive filaments, within necrotic tissue. An aspect of fasciitis of the left lower limb was also found. The macroscopic examination of the brain revealed an abscessed right frontal callosal mass (Figure 2) and satellite microabscesses separated from this main focal spot, associated with bilateral uncal herniation. During microscopy, we noticed zones of necrosis rich in altered polynuclear cells (Figure 3). PAS (periodic acid Schiff) and Grocott-positive mycelial strands were brought to light, often surrounded with polynuclear cells. Within these abscessed focal spots of mycelial origin, the branched-out aspect of filaments and their morphology suggested mycosis due to Aspergillus fumigates,


Association between a Primitive Brain Tumor and Cerebral Aspergillosis.

Hélage S, Duyckaerts C, Seilhean D, Hauw JJ, Chiras J - Case Rep Med (2012)

Autopsic brain coronal section. Right thalamus and corona radiata abscessed hemorrhagic infarcts.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3295534&req=5

fig2: Autopsic brain coronal section. Right thalamus and corona radiata abscessed hemorrhagic infarcts.
Mentions: on the infectious side, there were abscesses of both superior pulmonary lobes. The microscopic examination brought to light aspergillar abscesses with branched out Grocott-positive filaments, within necrotic tissue. An aspect of fasciitis of the left lower limb was also found. The macroscopic examination of the brain revealed an abscessed right frontal callosal mass (Figure 2) and satellite microabscesses separated from this main focal spot, associated with bilateral uncal herniation. During microscopy, we noticed zones of necrosis rich in altered polynuclear cells (Figure 3). PAS (periodic acid Schiff) and Grocott-positive mycelial strands were brought to light, often surrounded with polynuclear cells. Within these abscessed focal spots of mycelial origin, the branched-out aspect of filaments and their morphology suggested mycosis due to Aspergillus fumigates,

Bottom Line: This infection of the central nervous system is generally the complication of an invasive aspergillosis with hematogenic scattering from pulmonary focal spots.It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer.Clinicopathological aspects and therapeutic approach are described.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire de Neuropathologie Escourolle, Institut du Cerveau et de la Moelle épinière, Université Pierre et Marie Curie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 47-83 boulevard de l'Hôpital, 75651 Paris cedex 13, France.

ABSTRACT
Cerebral aspergillosis is a rare pathology of poor prognosis in spite of the use of adapted antifungal treatments. This infection of the central nervous system is generally the complication of an invasive aspergillosis with hematogenic scattering from pulmonary focal spots. It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer. A case of lethal cerebral aspergillosis in a patient with an infiltrative glioma treated with corticotherapy and radiotherapy is reported. Clinicopathological aspects and therapeutic approach are described.

No MeSH data available.


Related in: MedlinePlus