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Clarithromycin monohydrate: a synchrotron X-ray powder study.

Noguchi S, Fujiki S, Iwao Y, Miura K, Itai S - Acta Crystallogr Sect E Struct Rep Online (2012)

Bottom Line: In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring.The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring.The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.

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ABSTRACT
In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.

No MeSH data available.


The final Rietveld plot. The experimental diffraction profile is indicated by red crosses. The calculated diffraction and difference profiles are depicted as solid green and blue lines, respectively. The vertical green bars correspond to the positions of the Bragg peaks.
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Fap3: The final Rietveld plot. The experimental diffraction profile is indicated by red crosses. The calculated diffraction and difference profiles are depicted as solid green and blue lines, respectively. The vertical green bars correspond to the positions of the Bragg peaks.


Clarithromycin monohydrate: a synchrotron X-ray powder study.

Noguchi S, Fujiki S, Iwao Y, Miura K, Itai S - Acta Crystallogr Sect E Struct Rep Online (2012)

The final Rietveld plot. The experimental diffraction profile is indicated by red crosses. The calculated diffraction and difference profiles are depicted as solid green and blue lines, respectively. The vertical green bars correspond to the positions of the Bragg peaks.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3295456&req=5

Fap3: The final Rietveld plot. The experimental diffraction profile is indicated by red crosses. The calculated diffraction and difference profiles are depicted as solid green and blue lines, respectively. The vertical green bars correspond to the positions of the Bragg peaks.
Bottom Line: In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring.The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring.The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.

No MeSH data available.