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Association between pregnancy loss and urinary phthalate levels around the time of conception.

Toft G, Jönsson BA, Lindh CH, Jensen TK, Hjollund NH, Vested A, Bonde JP - Environ. Health Perspect. (2011)

Bottom Line: Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother.The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% CI: 4.5, 369.5).Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.

View Article: PubMed Central - PubMed

Affiliation: Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. guntof@rm.dk

ABSTRACT

Background: Animal studies indicate that some phthalate metabolites may harm female reproductive function.

Objectives: We assessed the associations between exposure to phthalate metabolites and pregnancy loss.

Methods: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, n = 111). Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother.

Results: Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio (OR) = 2.9; 95% confidence interval (CI): 1.1, 7.6]. The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% CI: 4.5, 369.5).

Conclusions: The phthalate metabolite MEHP was associated with higher occurrence of pregnancy loss. Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.

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Related in: MedlinePlus

Overview of the timing of selected samples for phthalate analyses in relation to time of conception, hCG analysis, and ascertainment of clinical pregnancy. The times given represent averages in the study population.
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f1: Overview of the timing of selected samples for phthalate analyses in relation to time of conception, hCG analysis, and ascertainment of clinical pregnancy. The times given represent averages in the study population.

Mentions: In 2009, at least one series of stored urine samples was available for 242 of the 430 women who were enrolled in the pregnancy planner study. In 77 women, no urine samples were collected because conception occurred during the first menstrual cycle. In addition, some samples (n = 111) were lost during the storage period for unknown reasons. Age and average amounts of smoking and drinking were very similar between women with and without analyzed samples; but waiting time to pregnancy was shorter and the proportion of couples achieving a pregnancy after 12 months was higher among women without phthalate measurements, because this group included a large proportion of women who became pregnant in the first menstrual cycle (data not shown). From each of the women with available urine samples, we selected up to two urine samples for analysis of phthalate metabolites (Figure 1), including one conception sample from day 10 after the first day of the last menstrual period before their first pregnancy (registered as either a clinical pregnancy or hCG elevation) (n = 128), and one preconception sample from day 10 of the previous menstrual period termed, when available (n = 111).


Association between pregnancy loss and urinary phthalate levels around the time of conception.

Toft G, Jönsson BA, Lindh CH, Jensen TK, Hjollund NH, Vested A, Bonde JP - Environ. Health Perspect. (2011)

Overview of the timing of selected samples for phthalate analyses in relation to time of conception, hCG analysis, and ascertainment of clinical pregnancy. The times given represent averages in the study population.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3295336&req=5

f1: Overview of the timing of selected samples for phthalate analyses in relation to time of conception, hCG analysis, and ascertainment of clinical pregnancy. The times given represent averages in the study population.
Mentions: In 2009, at least one series of stored urine samples was available for 242 of the 430 women who were enrolled in the pregnancy planner study. In 77 women, no urine samples were collected because conception occurred during the first menstrual cycle. In addition, some samples (n = 111) were lost during the storage period for unknown reasons. Age and average amounts of smoking and drinking were very similar between women with and without analyzed samples; but waiting time to pregnancy was shorter and the proportion of couples achieving a pregnancy after 12 months was higher among women without phthalate measurements, because this group included a large proportion of women who became pregnant in the first menstrual cycle (data not shown). From each of the women with available urine samples, we selected up to two urine samples for analysis of phthalate metabolites (Figure 1), including one conception sample from day 10 after the first day of the last menstrual period before their first pregnancy (registered as either a clinical pregnancy or hCG elevation) (n = 128), and one preconception sample from day 10 of the previous menstrual period termed, when available (n = 111).

Bottom Line: Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother.The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% CI: 4.5, 369.5).Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.

View Article: PubMed Central - PubMed

Affiliation: Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. guntof@rm.dk

ABSTRACT

Background: Animal studies indicate that some phthalate metabolites may harm female reproductive function.

Objectives: We assessed the associations between exposure to phthalate metabolites and pregnancy loss.

Methods: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n = 128) and during the previous cycle (if any, n = 111). Subclinical embryonal loss was identified by repeated measurement of urinary human chorionic gonadotropin, and information on clinical spontaneous abortions was obtained by telephone interview with the mother.

Results: Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio (OR) = 2.9; 95% confidence interval (CI): 1.1, 7.6]. The corresponding OR for subclinical embryonal loss (n = 32) was 40.7 (95% CI: 4.5, 369.5).

Conclusions: The phthalate metabolite MEHP was associated with higher occurrence of pregnancy loss. Because this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.

Show MeSH
Related in: MedlinePlus