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Chemokine receptor 5 △32 allele in patients with severe pandemic (H1N1) 2009.

Keynan Y, Juno J, Meyers A, Ball TB, Kumar A, Rubinstein E, Fowke KR - Emerging Infect. Dis. (2010)

Bottom Line: Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population.We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. keynany@yahoo.com

ABSTRACT
Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.

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Amplification of the chemokine receptor 5 (CCR5) Δ32 locus in white patients. Lane 1, heterozygous positive control; lanes 2–5 and 7–11, patient samples; lane 6, 100-bp ladder; lane 12, negative control. CCR5Δ32 heterozygosity is observed in samples 2, 3, 4, 5, and 11.
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Figure 1: Amplification of the chemokine receptor 5 (CCR5) Δ32 locus in white patients. Lane 1, heterozygous positive control; lanes 2–5 and 7–11, patient samples; lane 6, 100-bp ladder; lane 12, negative control. CCR5Δ32 heterozygosity is observed in samples 2, 3, 4, 5, and 11.

Mentions: The CCR5Δ32 allele was not found in the nonwhite patients, but it was found in 5 of the 9 white patients (Figure); overall allele frequency for white patients was 27.8%. Among the 5 who were heterozygous for the CCR5Δ32 allele, 1 died, 1 remained in the intensive care unit for >1 month, and 3 were discharged.


Chemokine receptor 5 △32 allele in patients with severe pandemic (H1N1) 2009.

Keynan Y, Juno J, Meyers A, Ball TB, Kumar A, Rubinstein E, Fowke KR - Emerging Infect. Dis. (2010)

Amplification of the chemokine receptor 5 (CCR5) Δ32 locus in white patients. Lane 1, heterozygous positive control; lanes 2–5 and 7–11, patient samples; lane 6, 100-bp ladder; lane 12, negative control. CCR5Δ32 heterozygosity is observed in samples 2, 3, 4, 5, and 11.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3294998&req=5

Figure 1: Amplification of the chemokine receptor 5 (CCR5) Δ32 locus in white patients. Lane 1, heterozygous positive control; lanes 2–5 and 7–11, patient samples; lane 6, 100-bp ladder; lane 12, negative control. CCR5Δ32 heterozygosity is observed in samples 2, 3, 4, 5, and 11.
Mentions: The CCR5Δ32 allele was not found in the nonwhite patients, but it was found in 5 of the 9 white patients (Figure); overall allele frequency for white patients was 27.8%. Among the 5 who were heterozygous for the CCR5Δ32 allele, 1 died, 1 remained in the intensive care unit for >1 month, and 3 were discharged.

Bottom Line: Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population.We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. keynany@yahoo.com

ABSTRACT
Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease.

Show MeSH