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The effect of erythromycin on gastrointestinal motility in subtotal gastrectomized patients.

Lee AL, Kim CB - J Korean Surg Soc (2012)

Bottom Line: No significant differences were found for the demographics between the two groups.We only found a significant difference for the number of Kolomarks passed by the stomach on the 3rd postoperative day (P = 0.026).Our results demonstrated that 200 mg of EM intravenous infusion during the postoperative period induced rapid gastric emptying, although it did not improve gastrointestinal motility for the entire gastrointestinal tract in subtotal gastrectomized patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Our objective was to determine the effect of erythromycin (EM) in improving gastrointestinal motility in subtotal gastrectomized patients. We used radio-opaque Kolomarks as an objective method. We conducted a prospective, controlled clinical trial study of 24 patients.

Methods: All patients underwent subtotal gastrectomy with 3 capsules containing Kolomarks (20 markers per 1 capsule) in the remnant stomach before anastomosis. From the day of the operation to the 2nd postoperative day, patients in the EM group began receiving 200 mg of EM intravenously for 30 minutes continuously. We counted the number of Kolomarks in the stomach, passed by stomach, in rectum, and in stool with serial simple abdominal X-ray films on the first postoperative day up to the 7th postoperative day.

Results: The study population included 14 patients in the control group and 10 patients in the EM group. The two study groups were compared in terms of their characteristics including age, gender, past medical history, cancer stage, and operation type. No significant differences were found for the demographics between the two groups. We only found a significant difference for the number of Kolomarks passed by the stomach on the 3rd postoperative day (P = 0.026).

Conclusion: Our results demonstrated that 200 mg of EM intravenous infusion during the postoperative period induced rapid gastric emptying, although it did not improve gastrointestinal motility for the entire gastrointestinal tract in subtotal gastrectomized patients.

No MeSH data available.


Related in: MedlinePlus

Abdominal X-ray film in erythromycin group on 1st postoperative day. There are 57 Kolomarks in stomach.
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Figure 1: Abdominal X-ray film in erythromycin group on 1st postoperative day. There are 57 Kolomarks in stomach.

Mentions: The mean values for the glucose levels on the 1st, 3rd, and 7th postoperative day were higher in the EM group than in the control group, although there were no significant differences in each group. The mean values in the EM group for the passage of flatus and length of hospital stay were lower than in the control group. However, no significant differences were founded in each group (80.6 ± 23.8 in the control group vs. 78.8 ± 7.6 in the EM group; P = 0.744). Abdominal X-ray films were used to count the number of Kolomarks for each postoperative day (Figs. 1-4). On the 1st postoperative day, the mean value of the number of Kolomarks in the stomach was found to be higher in EM group than in the control group (54.8 ± 8.0 in the control group vs. 55.5 ± 4.9 in the EM group). The mean value of the number of Kolomarks passed by stomach on the 3rd postoperative day in the EM group was higher than in the control group (30.8 ± 25.6 in the control group vs. 49.9 ± 17.7 in the EM group). The mean values of the number of Kolomarks in the rectum on the 3rd postoperative day and in the stool on 5th and 7th postoperative day, also, were higher in the EM group than in the control group (0.4 ± 0.7 in the control group vs. 1.2 ± 1.6 in the EM group, 5.2 ± 12.4 in the control group vs. 10.5 ± 17.7 in the EM group, 19.9 ± 22.6 in the control group vs. 23.6 ± 25.1 in the EM group, respectively). However, we only found a significant difference for the number of Kolomarks passed by the stomach on the 3rd postoperative day (P = 0.026) (Table 2).


The effect of erythromycin on gastrointestinal motility in subtotal gastrectomized patients.

Lee AL, Kim CB - J Korean Surg Soc (2012)

Abdominal X-ray film in erythromycin group on 1st postoperative day. There are 57 Kolomarks in stomach.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3294108&req=5

Figure 1: Abdominal X-ray film in erythromycin group on 1st postoperative day. There are 57 Kolomarks in stomach.
Mentions: The mean values for the glucose levels on the 1st, 3rd, and 7th postoperative day were higher in the EM group than in the control group, although there were no significant differences in each group. The mean values in the EM group for the passage of flatus and length of hospital stay were lower than in the control group. However, no significant differences were founded in each group (80.6 ± 23.8 in the control group vs. 78.8 ± 7.6 in the EM group; P = 0.744). Abdominal X-ray films were used to count the number of Kolomarks for each postoperative day (Figs. 1-4). On the 1st postoperative day, the mean value of the number of Kolomarks in the stomach was found to be higher in EM group than in the control group (54.8 ± 8.0 in the control group vs. 55.5 ± 4.9 in the EM group). The mean value of the number of Kolomarks passed by stomach on the 3rd postoperative day in the EM group was higher than in the control group (30.8 ± 25.6 in the control group vs. 49.9 ± 17.7 in the EM group). The mean values of the number of Kolomarks in the rectum on the 3rd postoperative day and in the stool on 5th and 7th postoperative day, also, were higher in the EM group than in the control group (0.4 ± 0.7 in the control group vs. 1.2 ± 1.6 in the EM group, 5.2 ± 12.4 in the control group vs. 10.5 ± 17.7 in the EM group, 19.9 ± 22.6 in the control group vs. 23.6 ± 25.1 in the EM group, respectively). However, we only found a significant difference for the number of Kolomarks passed by the stomach on the 3rd postoperative day (P = 0.026) (Table 2).

Bottom Line: No significant differences were found for the demographics between the two groups.We only found a significant difference for the number of Kolomarks passed by the stomach on the 3rd postoperative day (P = 0.026).Our results demonstrated that 200 mg of EM intravenous infusion during the postoperative period induced rapid gastric emptying, although it did not improve gastrointestinal motility for the entire gastrointestinal tract in subtotal gastrectomized patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Our objective was to determine the effect of erythromycin (EM) in improving gastrointestinal motility in subtotal gastrectomized patients. We used radio-opaque Kolomarks as an objective method. We conducted a prospective, controlled clinical trial study of 24 patients.

Methods: All patients underwent subtotal gastrectomy with 3 capsules containing Kolomarks (20 markers per 1 capsule) in the remnant stomach before anastomosis. From the day of the operation to the 2nd postoperative day, patients in the EM group began receiving 200 mg of EM intravenously for 30 minutes continuously. We counted the number of Kolomarks in the stomach, passed by stomach, in rectum, and in stool with serial simple abdominal X-ray films on the first postoperative day up to the 7th postoperative day.

Results: The study population included 14 patients in the control group and 10 patients in the EM group. The two study groups were compared in terms of their characteristics including age, gender, past medical history, cancer stage, and operation type. No significant differences were found for the demographics between the two groups. We only found a significant difference for the number of Kolomarks passed by the stomach on the 3rd postoperative day (P = 0.026).

Conclusion: Our results demonstrated that 200 mg of EM intravenous infusion during the postoperative period induced rapid gastric emptying, although it did not improve gastrointestinal motility for the entire gastrointestinal tract in subtotal gastrectomized patients.

No MeSH data available.


Related in: MedlinePlus