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e-PKGene: a knowledge-based research tool for analysing the impact of genetics on drug exposure.

Hachad H, Overby CL, Argon S, Yeung CK, Ragueneau-Majlessi I, Levy RH - Hum. Genomics (2011)

Bottom Line: The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information.It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites.This review gives a brief description of the database organisation, its search functionalities and examples of use.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmaceutics, University of Washington, Seattle, USA.

ABSTRACT
e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.

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Related in: MedlinePlus

Sample 'impact of pharmacokinetics' screen for PMID 17947222. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).
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Figure 6: Sample 'impact of pharmacokinetics' screen for PMID 17947222. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).

Mentions: More detailed information is retrieved in the 'impact of pharmacokinetics' screen for an individual citation (Figure 6), where specific pharmacokinetic parameters (AUC, clearance or plasma concentration) for the selected compound and any active metabolites are displayed for all the studies. Additional information extracted from the citation is displayed in the 'full study set' section.


e-PKGene: a knowledge-based research tool for analysing the impact of genetics on drug exposure.

Hachad H, Overby CL, Argon S, Yeung CK, Ragueneau-Majlessi I, Levy RH - Hum. Genomics (2011)

Sample 'impact of pharmacokinetics' screen for PMID 17947222. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3286185&req=5

Figure 6: Sample 'impact of pharmacokinetics' screen for PMID 17947222. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).
Mentions: More detailed information is retrieved in the 'impact of pharmacokinetics' screen for an individual citation (Figure 6), where specific pharmacokinetic parameters (AUC, clearance or plasma concentration) for the selected compound and any active metabolites are displayed for all the studies. Additional information extracted from the citation is displayed in the 'full study set' section.

Bottom Line: The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information.It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites.This review gives a brief description of the database organisation, its search functionalities and examples of use.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmaceutics, University of Washington, Seattle, USA.

ABSTRACT
e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.

Show MeSH
Related in: MedlinePlus