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e-PKGene: a knowledge-based research tool for analysing the impact of genetics on drug exposure.

Hachad H, Overby CL, Argon S, Yeung CK, Ragueneau-Majlessi I, Levy RH - Hum. Genomics (2011)

Bottom Line: The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information.It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites.This review gives a brief description of the database organisation, its search functionalities and examples of use.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmaceutics, University of Washington, Seattle, USA.

ABSTRACT
e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.

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Related in: MedlinePlus

Example of initial search page. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).
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Figure 2: Example of initial search page. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).

Mentions: The e-PKGene website allows initial searching based on compound (or metabolite), gene or population. Selection of a search category retrieves a list of all available options. For example, a search by gene generates an alphabetical list of all compounds and metabolites with available data. In the following example (Figure 2), a tamoxifen-based search is conducted. The tamoxifen query generates a results screen (Figure 3) which indicates the total number of available citations, the genes studied and the examined populations (with the number of citations). Note that tamoxifen has been flagged as a 'prodrug' (circled in red) to remind the user that additional information may be available by searching for the active moiety. Beneath the summary of results table, the citations are listed chronologically, along with their PMID number.


e-PKGene: a knowledge-based research tool for analysing the impact of genetics on drug exposure.

Hachad H, Overby CL, Argon S, Yeung CK, Ragueneau-Majlessi I, Levy RH - Hum. Genomics (2011)

Example of initial search page. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3286185&req=5

Figure 2: Example of initial search page. Display from e-PKGene ((http://www.pharmacogeneticsinfo.org); accessed 18th November 2010).
Mentions: The e-PKGene website allows initial searching based on compound (or metabolite), gene or population. Selection of a search category retrieves a list of all available options. For example, a search by gene generates an alphabetical list of all compounds and metabolites with available data. In the following example (Figure 2), a tamoxifen-based search is conducted. The tamoxifen query generates a results screen (Figure 3) which indicates the total number of available citations, the genes studied and the examined populations (with the number of citations). Note that tamoxifen has been flagged as a 'prodrug' (circled in red) to remind the user that additional information may be available by searching for the active moiety. Beneath the summary of results table, the citations are listed chronologically, along with their PMID number.

Bottom Line: The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information.It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites.This review gives a brief description of the database organisation, its search functionalities and examples of use.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmaceutics, University of Washington, Seattle, USA.

ABSTRACT
e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.

Show MeSH
Related in: MedlinePlus