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New methods for finding disease-susceptibility genes: impact and potential.

McCarthy MI, Smedley D, Hide W - Genome Biol. (2003)

Bottom Line: Improved techniques for defining disease-gene location and evaluating the biological candidacy of regional transcripts will hasten disease-gene discovery.

View Article: PubMed Central - HTML - PubMed

Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, Headington, Oxford 0X3 7LJ, UK. mark.mccarthy@drl.ox.ac.uk

ABSTRACT
Improved techniques for defining disease-gene location and evaluating the biological candidacy of regional transcripts will hasten disease-gene discovery.

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Related in: MedlinePlus

Candidate-gene identification past and present. In the past, the emphasis was on using linkage analysis to direct positional-cloning efforts, and on the application of our limited understanding of disease pathogenesis to select biologically relevant candidate genes. Now, additional techniques are providing new routes to the identification of disease-susceptibility genes. See text for further details.
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Figure 1: Candidate-gene identification past and present. In the past, the emphasis was on using linkage analysis to direct positional-cloning efforts, and on the application of our limited understanding of disease pathogenesis to select biologically relevant candidate genes. Now, additional techniques are providing new routes to the identification of disease-susceptibility genes. See text for further details.

Mentions: The key to accelerating the discovery of susceptibility genes for multifactorial conditions clearly lies in developing improved strategies for refining both disease-gene location and assessments of biological candidacy (see Figure 1). This article describes some recent developments, with an emphasis on their impact on susceptibility-gene identification in man.


New methods for finding disease-susceptibility genes: impact and potential.

McCarthy MI, Smedley D, Hide W - Genome Biol. (2003)

Candidate-gene identification past and present. In the past, the emphasis was on using linkage analysis to direct positional-cloning efforts, and on the application of our limited understanding of disease pathogenesis to select biologically relevant candidate genes. Now, additional techniques are providing new routes to the identification of disease-susceptibility genes. See text for further details.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC328443&req=5

Figure 1: Candidate-gene identification past and present. In the past, the emphasis was on using linkage analysis to direct positional-cloning efforts, and on the application of our limited understanding of disease pathogenesis to select biologically relevant candidate genes. Now, additional techniques are providing new routes to the identification of disease-susceptibility genes. See text for further details.
Mentions: The key to accelerating the discovery of susceptibility genes for multifactorial conditions clearly lies in developing improved strategies for refining both disease-gene location and assessments of biological candidacy (see Figure 1). This article describes some recent developments, with an emphasis on their impact on susceptibility-gene identification in man.

Bottom Line: Improved techniques for defining disease-gene location and evaluating the biological candidacy of regional transcripts will hasten disease-gene discovery.

View Article: PubMed Central - HTML - PubMed

Affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, Headington, Oxford 0X3 7LJ, UK. mark.mccarthy@drl.ox.ac.uk

ABSTRACT
Improved techniques for defining disease-gene location and evaluating the biological candidacy of regional transcripts will hasten disease-gene discovery.

Show MeSH
Related in: MedlinePlus