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Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study.

Brooks SJ, Barker GJ, O'Daly OG, Brammer M, Williams SC, Benedict C, Schiöth HB, Treasure J, Campbell IC - BMC Psychiatry (2011)

Bottom Line: Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC.RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum.In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions.

View Article: PubMed Central - HTML - PubMed

Affiliation: Section of Eating Disorders, Institute of Psychiatry, King's College London, London, SE5 8AF UK. samantha.brooks@neuro.uu.se

ABSTRACT

Background: Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume.

Methods: Voxel based morphometry (VBM), corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN) and 21 women (HC) was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS).

Results: Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN.

Conclusions: In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions. Differences in regional GMV may be linked to levels of appetitive restraint, but whether they are state or trait is unclear. Nevertheless, these discrete brain volume differences provide candidate brain regions for further structural and functional study in people with eating disorders.

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Related in: MedlinePlus

Gray matter differences between women with restricting (n = 8) and binge purge AN (n = 6). Voxel-based morphometry maps thresholded at p = 0.01 for false positives and corrected for covariates (Total gray matter volume, Age, BMI, Years Education, Trait Anxiety). Red indicates deficits in gray matter volume in women with RAN compared to BPAN. Z score coordinates given are from the Talairach atlas.
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Figure 2: Gray matter differences between women with restricting (n = 8) and binge purge AN (n = 6). Voxel-based morphometry maps thresholded at p = 0.01 for false positives and corrected for covariates (Total gray matter volume, Age, BMI, Years Education, Trait Anxiety). Red indicates deficits in gray matter volume in women with RAN compared to BPAN. Z score coordinates given are from the Talairach atlas.

Mentions: After correcting for total GMV, age, BMI, years of education and trait anxiety, the data shows that relative to the BPAN group, the RAN group, had significantly lower GMV in the left cerebellum, bilateral parahippocampal gyrus, right anterior insula and left orbitofrontal cortex (OFC) (P < 0.001). See Table 4 Figure 2.


Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study.

Brooks SJ, Barker GJ, O'Daly OG, Brammer M, Williams SC, Benedict C, Schiöth HB, Treasure J, Campbell IC - BMC Psychiatry (2011)

Gray matter differences between women with restricting (n = 8) and binge purge AN (n = 6). Voxel-based morphometry maps thresholded at p = 0.01 for false positives and corrected for covariates (Total gray matter volume, Age, BMI, Years Education, Trait Anxiety). Red indicates deficits in gray matter volume in women with RAN compared to BPAN. Z score coordinates given are from the Talairach atlas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3278387&req=5

Figure 2: Gray matter differences between women with restricting (n = 8) and binge purge AN (n = 6). Voxel-based morphometry maps thresholded at p = 0.01 for false positives and corrected for covariates (Total gray matter volume, Age, BMI, Years Education, Trait Anxiety). Red indicates deficits in gray matter volume in women with RAN compared to BPAN. Z score coordinates given are from the Talairach atlas.
Mentions: After correcting for total GMV, age, BMI, years of education and trait anxiety, the data shows that relative to the BPAN group, the RAN group, had significantly lower GMV in the left cerebellum, bilateral parahippocampal gyrus, right anterior insula and left orbitofrontal cortex (OFC) (P < 0.001). See Table 4 Figure 2.

Bottom Line: Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC.RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum.In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions.

View Article: PubMed Central - HTML - PubMed

Affiliation: Section of Eating Disorders, Institute of Psychiatry, King's College London, London, SE5 8AF UK. samantha.brooks@neuro.uu.se

ABSTRACT

Background: Previous Magnetic Resonance Imaging (MRI) studies of people with anorexia nervosa (AN) have shown differences in brain structure. This study aimed to provide preliminary extensions of this data by examining how different levels of appetitive restraint impact on brain volume.

Methods: Voxel based morphometry (VBM), corrected for total intracranial volume, age, BMI, years of education in 14 women with AN (8 RAN and 6 BPAN) and 21 women (HC) was performed. Correlations between brain volume and dietary restraint were done using Statistical Package for the Social Sciences (SPSS).

Results: Increased right dorsolateral prefrontal cortex (DLPFC) and reduced right anterior insular cortex, bilateral parahippocampal gyrus, left fusiform gyrus, left cerebellum and right posterior cingulate volumes in AN compared to HC. RAN compared to BPAN had reduced left orbitofrontal cortex, right anterior insular cortex, bilateral parahippocampal gyrus and left cerebellum. Age negatively correlated with right DLPFC volume in HC but not in AN; dietary restraint and BMI predicted 57% of variance in right DLPFC volume in AN.

Conclusions: In AN, brain volume differences were found in appetitive, somatosensory and top-down control brain regions. Differences in regional GMV may be linked to levels of appetitive restraint, but whether they are state or trait is unclear. Nevertheless, these discrete brain volume differences provide candidate brain regions for further structural and functional study in people with eating disorders.

Show MeSH
Related in: MedlinePlus