Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurements.
Bottom Line: In comparison to the purely elastic model, visco-elasticity significantly reduced the average relative root-mean-square errors between numerical and experimental waveforms over the 70 locations measured in the in vitro model: from 3.0% to 2.5% (p<0.012) for pressure and from 15.7% to 10.8% (p<0.002) for the flow rate.In the frequency domain, average relative errors between numerical and experimental amplitudes from the 5th to the 20th harmonic decreased from 0.7% to 0.5% (p<0.107) for pressure and from 7.0% to 3.3% (p<10(-6)) for the flow rate.These results provide additional support for the use of 1-D reduced modelling to accurately simulate clinically relevant problems at a reasonable computational cost.
Affiliation: Department of Bioengineering, Imperial College, London SW7 2AZ, UK. email@example.comShow MeSH
Mentions: Here we estimated (which was not measured in Matthys et al., 2007) from an uniaxial extension test in a sample of the same silicone material used in the experimental setup. Fig. 2 (top) shows the extension and measured load F used in the test, which were normalised by their corresponding maximum values Fmax and . The test was carried out using a tensometer and 1 kN load cell (Instron 5542, High Wycombe, UK), loading and unloading at a rate of 20 mm to a maximum extension of 1 mm. Three consecutive loading and unloading cycles were followed by 30 s at zero extension, loading to maximum extension which was held for 60 s before the final unloading to zero extension.
Affiliation: Department of Bioengineering, Imperial College, London SW7 2AZ, UK. firstname.lastname@example.org