Limits...
Association between diabetes complications and leukocyte counts in Iranian patients.

Moradi S, Kerman SR, Rohani F, Salari F - J Inflamm Res (2012)

Bottom Line: They are also renowned for being an economic burden.The study was carried out in Iran during 2007 and 2008.The subjects were split into two groups according to their leukocyte levels: low (≤7000/mm(3)) and high (>7000/mm(3)); and then analyzed by Student's t-test or Mann-Whitney U-test as appropriate.

View Article: PubMed Central - PubMed

Affiliation: Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications.

Methods: The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low (≤7000/mm(3)) and high (>7000/mm(3)); and then analyzed by Student's t-test or Mann-Whitney U-test as appropriate.

Results: The average leukocyte count in these patients was 7594 ± 1965/mm(3). Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P < 0.0001). According to this analysis, a leukocyte count of 6750/mm(3) with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm(3) with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication.

Conclusion: An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.

No MeSH data available.


Related in: MedlinePlus

ROC analysis based on having at least one microvascular complication.Abbreviation: ROC, receiver operating characteristic.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3278259&req=5

f1-jir-5-007: ROC analysis based on having at least one microvascular complication.Abbreviation: ROC, receiver operating characteristic.

Mentions: Leukocyte counts had significant difference in patients with and without retinopathy and albuminuria (P < 0.0001). Furthermore, the subjects were divided into two groups according to any kind of complication and we found a significant difference in leukocyte counts within these groups (P < 0.0001). Receiver operating characteristic analysis was done to find the best cutoff point for leukocyte counts in relation to any complications. According to this analysis, a leukocyte count of 6750/mm3 with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm3 with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication. Our cutoff point of 7000/mm3 had a sensitivity of 73.3% and a specificity of 66.0% (area under the curve = 0.778, P < 0.0001), (Figure 1).


Association between diabetes complications and leukocyte counts in Iranian patients.

Moradi S, Kerman SR, Rohani F, Salari F - J Inflamm Res (2012)

ROC analysis based on having at least one microvascular complication.Abbreviation: ROC, receiver operating characteristic.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3278259&req=5

f1-jir-5-007: ROC analysis based on having at least one microvascular complication.Abbreviation: ROC, receiver operating characteristic.
Mentions: Leukocyte counts had significant difference in patients with and without retinopathy and albuminuria (P < 0.0001). Furthermore, the subjects were divided into two groups according to any kind of complication and we found a significant difference in leukocyte counts within these groups (P < 0.0001). Receiver operating characteristic analysis was done to find the best cutoff point for leukocyte counts in relation to any complications. According to this analysis, a leukocyte count of 6750/mm3 with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm3 with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication. Our cutoff point of 7000/mm3 had a sensitivity of 73.3% and a specificity of 66.0% (area under the curve = 0.778, P < 0.0001), (Figure 1).

Bottom Line: They are also renowned for being an economic burden.The study was carried out in Iran during 2007 and 2008.The subjects were split into two groups according to their leukocyte levels: low (≤7000/mm(3)) and high (>7000/mm(3)); and then analyzed by Student's t-test or Mann-Whitney U-test as appropriate.

View Article: PubMed Central - PubMed

Affiliation: Endocrine and Metabolism Research Center (Firouzgar), Hemmat Campus, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT

Background: The long term complications of diabetes can be fatal. They are also renowned for being an economic burden. Previous studies have demonstrated a relationship between inflammatory markers and complications of diabetes. The objective of this study was to evaluate the relationship between leukocyte counts and these complications.

Methods: The study included 184 patients diagnosed with type 2 diabetes. The study was carried out in Iran during 2007 and 2008. Data collected on the subjects were as follows: age, gender, weight, height, blood pressure, smoking history, lipid profile including low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol, triglycerides, and leukocyte count, albuminuria, and retinopathy. Furthermore, information on cardiac history for 100 patients was collected. The subjects were split into two groups according to their leukocyte levels: low (≤7000/mm(3)) and high (>7000/mm(3)); and then analyzed by Student's t-test or Mann-Whitney U-test as appropriate.

Results: The average leukocyte count in these patients was 7594 ± 1965/mm(3). Leukocyte count was significantly different in patients with and without retinopathy and albuminuria (P < 0.0001). According to this analysis, a leukocyte count of 6750/mm(3) with a sensitivity of 80.2% and a specificity of 56.4%, and a count of 7550/mm(3) with a sensitivity of 63.2% and a specificity of 74.6% indicated at least one diabetes complication.

Conclusion: An elevated leukocyte count even within the normal range was associated with chronic complications in type 2 diabetes.

No MeSH data available.


Related in: MedlinePlus