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Phenotype characterization of embryoid body structures generated by a crystal comet effect tail in an intercellular cancer collision scenario.

Diaz JA, Murillo MF - Cancer Manag Res (2012)

Bottom Line: The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation.Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues.Reversal mechanisms in biology are intimately linked with DNA repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hospital Departmental Villavicencio, Hospital Departmental Granada, Medicine School, University Cooperative of Colombia, Villavicencio, Meta, Colombia.

ABSTRACT
Cancer is, by definition, the uncontrolled growth of autonomous cells that eventually destroy adjacent tissues and generate architectural disorder. However, this concept cannot be totally true. In three well documented studies, we have demonstrated that cancer tissues produce order zones that evolve over time and generate embryoid body structures in a space-time interval. The authors decided to revise the macroscopic and microscopic material in well-developed malignant tumors in which embryoid bodies were identified to determine the phenotype characterization that serves as a guideline for easy recognition. The factors responsible for this morphogenesis are physical, bioelectric, and magnetic susceptibilities produced by crystals that act as molecular designers for the topographic gradients that guide the surrounding silhouette and establish tissue head-tail positional identities. The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation. Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues. The significance of these observations is that they can also be predicted by experimental image data collected by the Large Hadron Collider (LHC) accelerator at the European Organization for Nuclear Research, in which two-beam subatomic collision particles in the resulting debris show hyperorder domains similar to those identified by us in intercellular cancer collisions. Our findings suggest that we are dealing with true reverse biologic system information in an activated collective cancer stem cell memory, in which physics participates in the elaboration of geometric complexes and chiral biomolecules that serve to build bodies with embryoid print as it develops during gestation. Reversal mechanisms in biology are intimately linked with DNA repair. Further genotype studies must be carried out to determine whether the subproducts of these structures can be used in novel strategies to treat cancer.

No MeSH data available.


Related in: MedlinePlus

Close-up observation of scheduled short crystal migrations that guide and sculpt the surrounding silhouette characteristics of the embryo body with surprising precision. (A) Detachment subimage of (B) image, demonstrating geometric template platform guided by crystal displacement establishing head, tail positional identity in a case of endometrial adenocarcinoma, endocervical smear, Papanicolaou staining (40×). (C) Detachment panoramic subimage of (D, E, and F) which reveals in detail how short crystal migrations sculpting the surrounding embryoid body silhouette establish positional tissue ligands in a case of peritoneal carcinomatosis ascitic fluid. Papanicolaou staining (40×). (G) Well defined embryoid body in a case of breast adenocarcinoma with hematoxylin and eosin staining (20×). (H) Detachment subimage of (I) image which reveals embryoid body segmentation generated by massive crystal synchronic migrations in a case of undifferentiated necrotic tumor with hematoxylin and eosin staining (20×).
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f3-cmar-4-009: Close-up observation of scheduled short crystal migrations that guide and sculpt the surrounding silhouette characteristics of the embryo body with surprising precision. (A) Detachment subimage of (B) image, demonstrating geometric template platform guided by crystal displacement establishing head, tail positional identity in a case of endometrial adenocarcinoma, endocervical smear, Papanicolaou staining (40×). (C) Detachment panoramic subimage of (D, E, and F) which reveals in detail how short crystal migrations sculpting the surrounding embryoid body silhouette establish positional tissue ligands in a case of peritoneal carcinomatosis ascitic fluid. Papanicolaou staining (40×). (G) Well defined embryoid body in a case of breast adenocarcinoma with hematoxylin and eosin staining (20×). (H) Detachment subimage of (I) image which reveals embryoid body segmentation generated by massive crystal synchronic migrations in a case of undifferentiated necrotic tumor with hematoxylin and eosin staining (20×).

Mentions: The morphogenesis of this embryoid body is attributable to scheduled short crystal migrations that act as molecular designers for the fine topographic map gradients that guide and sculpt the surrounding silhouette characteristics of the embryo body with surprising precision. These crystal migrations apparently generate the guidance ligand between cells that establishes head-tail positional identities (Figure 3A–I). The structures are located in a time-space interval within amniotic cavity-like domains, which are similar to a cordon (Figure 4A–I). The structures have the ability to generate mirror and fractal images (Figure 5A–I). Embryoid bodies show characteristic somite-like embryologic segmentation (Figure 6A–I). In our observations, the phenotype was more relevant, and a frequent characteristic was the positional identity within the crystal at the site of the optic placode assembled from the trajectory of the crystal that migrates from different positions and converges in the optic cavity, similar to somite-like structures.


Phenotype characterization of embryoid body structures generated by a crystal comet effect tail in an intercellular cancer collision scenario.

Diaz JA, Murillo MF - Cancer Manag Res (2012)

Close-up observation of scheduled short crystal migrations that guide and sculpt the surrounding silhouette characteristics of the embryo body with surprising precision. (A) Detachment subimage of (B) image, demonstrating geometric template platform guided by crystal displacement establishing head, tail positional identity in a case of endometrial adenocarcinoma, endocervical smear, Papanicolaou staining (40×). (C) Detachment panoramic subimage of (D, E, and F) which reveals in detail how short crystal migrations sculpting the surrounding embryoid body silhouette establish positional tissue ligands in a case of peritoneal carcinomatosis ascitic fluid. Papanicolaou staining (40×). (G) Well defined embryoid body in a case of breast adenocarcinoma with hematoxylin and eosin staining (20×). (H) Detachment subimage of (I) image which reveals embryoid body segmentation generated by massive crystal synchronic migrations in a case of undifferentiated necrotic tumor with hematoxylin and eosin staining (20×).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3278205&req=5

f3-cmar-4-009: Close-up observation of scheduled short crystal migrations that guide and sculpt the surrounding silhouette characteristics of the embryo body with surprising precision. (A) Detachment subimage of (B) image, demonstrating geometric template platform guided by crystal displacement establishing head, tail positional identity in a case of endometrial adenocarcinoma, endocervical smear, Papanicolaou staining (40×). (C) Detachment panoramic subimage of (D, E, and F) which reveals in detail how short crystal migrations sculpting the surrounding embryoid body silhouette establish positional tissue ligands in a case of peritoneal carcinomatosis ascitic fluid. Papanicolaou staining (40×). (G) Well defined embryoid body in a case of breast adenocarcinoma with hematoxylin and eosin staining (20×). (H) Detachment subimage of (I) image which reveals embryoid body segmentation generated by massive crystal synchronic migrations in a case of undifferentiated necrotic tumor with hematoxylin and eosin staining (20×).
Mentions: The morphogenesis of this embryoid body is attributable to scheduled short crystal migrations that act as molecular designers for the fine topographic map gradients that guide and sculpt the surrounding silhouette characteristics of the embryo body with surprising precision. These crystal migrations apparently generate the guidance ligand between cells that establishes head-tail positional identities (Figure 3A–I). The structures are located in a time-space interval within amniotic cavity-like domains, which are similar to a cordon (Figure 4A–I). The structures have the ability to generate mirror and fractal images (Figure 5A–I). Embryoid bodies show characteristic somite-like embryologic segmentation (Figure 6A–I). In our observations, the phenotype was more relevant, and a frequent characteristic was the positional identity within the crystal at the site of the optic placode assembled from the trajectory of the crystal that migrates from different positions and converges in the optic cavity, similar to somite-like structures.

Bottom Line: The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation.Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues.Reversal mechanisms in biology are intimately linked with DNA repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hospital Departmental Villavicencio, Hospital Departmental Granada, Medicine School, University Cooperative of Colombia, Villavicencio, Meta, Colombia.

ABSTRACT
Cancer is, by definition, the uncontrolled growth of autonomous cells that eventually destroy adjacent tissues and generate architectural disorder. However, this concept cannot be totally true. In three well documented studies, we have demonstrated that cancer tissues produce order zones that evolve over time and generate embryoid body structures in a space-time interval. The authors decided to revise the macroscopic and microscopic material in well-developed malignant tumors in which embryoid bodies were identified to determine the phenotype characterization that serves as a guideline for easy recognition. The factors responsible for this morphogenesis are physical, bioelectric, and magnetic susceptibilities produced by crystals that act as molecular designers for the topographic gradients that guide the surrounding silhouette and establish tissue head-tail positional identities. The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation. Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues. The significance of these observations is that they can also be predicted by experimental image data collected by the Large Hadron Collider (LHC) accelerator at the European Organization for Nuclear Research, in which two-beam subatomic collision particles in the resulting debris show hyperorder domains similar to those identified by us in intercellular cancer collisions. Our findings suggest that we are dealing with true reverse biologic system information in an activated collective cancer stem cell memory, in which physics participates in the elaboration of geometric complexes and chiral biomolecules that serve to build bodies with embryoid print as it develops during gestation. Reversal mechanisms in biology are intimately linked with DNA repair. Further genotype studies must be carried out to determine whether the subproducts of these structures can be used in novel strategies to treat cancer.

No MeSH data available.


Related in: MedlinePlus