Limits...
Phenotype characterization of embryoid body structures generated by a crystal comet effect tail in an intercellular cancer collision scenario.

Diaz JA, Murillo MF - Cancer Manag Res (2012)

Bottom Line: The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation.Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues.Reversal mechanisms in biology are intimately linked with DNA repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hospital Departmental Villavicencio, Hospital Departmental Granada, Medicine School, University Cooperative of Colombia, Villavicencio, Meta, Colombia.

ABSTRACT
Cancer is, by definition, the uncontrolled growth of autonomous cells that eventually destroy adjacent tissues and generate architectural disorder. However, this concept cannot be totally true. In three well documented studies, we have demonstrated that cancer tissues produce order zones that evolve over time and generate embryoid body structures in a space-time interval. The authors decided to revise the macroscopic and microscopic material in well-developed malignant tumors in which embryoid bodies were identified to determine the phenotype characterization that serves as a guideline for easy recognition. The factors responsible for this morphogenesis are physical, bioelectric, and magnetic susceptibilities produced by crystals that act as molecular designers for the topographic gradients that guide the surrounding silhouette and establish tissue head-tail positional identities. The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation. Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues. The significance of these observations is that they can also be predicted by experimental image data collected by the Large Hadron Collider (LHC) accelerator at the European Organization for Nuclear Research, in which two-beam subatomic collision particles in the resulting debris show hyperorder domains similar to those identified by us in intercellular cancer collisions. Our findings suggest that we are dealing with true reverse biologic system information in an activated collective cancer stem cell memory, in which physics participates in the elaboration of geometric complexes and chiral biomolecules that serve to build bodies with embryoid print as it develops during gestation. Reversal mechanisms in biology are intimately linked with DNA repair. Further genotype studies must be carried out to determine whether the subproducts of these structures can be used in novel strategies to treat cancer.

No MeSH data available.


Related in: MedlinePlus

Crystals generate embryoid bodies in the interior of the hexagonal geometry. (A) Detachment subimage of (B) image of embryoid body self-assembly into a geometric triangular chiral hexagonal-like crystal complex in a case of colon adenocarcinoma with hematoxylin and eosin staining (20×). (C) Detachment subimage of (D) image of embryoid body into hexagonal-like crystal complex in a case of lung squamous cell carcinoma with hematoxylin and eosin staining (20×). (E,F) Embryoid body self-assembly in a case of prostate adenocarcinoma with hematoxylin and eosin staining (40×). (G) Well defined embryoid formation in a case of Grade 1 cervical intraepithelial neoplasia with hematoxylin and eosin staining (20×). (H and I) Macroscopic representation of an embryoid body assembled into a geometric hexagonal template platform in a case of gastric adenocarcinoma.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3278205&req=5

f2-cmar-4-009: Crystals generate embryoid bodies in the interior of the hexagonal geometry. (A) Detachment subimage of (B) image of embryoid body self-assembly into a geometric triangular chiral hexagonal-like crystal complex in a case of colon adenocarcinoma with hematoxylin and eosin staining (20×). (C) Detachment subimage of (D) image of embryoid body into hexagonal-like crystal complex in a case of lung squamous cell carcinoma with hematoxylin and eosin staining (20×). (E,F) Embryoid body self-assembly in a case of prostate adenocarcinoma with hematoxylin and eosin staining (40×). (G) Well defined embryoid formation in a case of Grade 1 cervical intraepithelial neoplasia with hematoxylin and eosin staining (20×). (H and I) Macroscopic representation of an embryoid body assembled into a geometric hexagonal template platform in a case of gastric adenocarcinoma.

Mentions: When the hexagon is assembled, the walls of the crystal structure trap molecules in their interior. In this closed environment, when the collision process stops, deceleration of the particles generates subcollisions and subejected crystal effect tails. It is at this particular moment that migration of crystals occurs in the interior of the hexagon embryoid bodies. It is conceivable from the biological point of view, that this process adds new amino acids to a chain reaction protein core with the creation of folding macromolecule adequate positional print identity (Figure 2A–I). The point at which electromagnetism and biology converges is when the appearance of these structures is detected.


Phenotype characterization of embryoid body structures generated by a crystal comet effect tail in an intercellular cancer collision scenario.

Diaz JA, Murillo MF - Cancer Manag Res (2012)

Crystals generate embryoid bodies in the interior of the hexagonal geometry. (A) Detachment subimage of (B) image of embryoid body self-assembly into a geometric triangular chiral hexagonal-like crystal complex in a case of colon adenocarcinoma with hematoxylin and eosin staining (20×). (C) Detachment subimage of (D) image of embryoid body into hexagonal-like crystal complex in a case of lung squamous cell carcinoma with hematoxylin and eosin staining (20×). (E,F) Embryoid body self-assembly in a case of prostate adenocarcinoma with hematoxylin and eosin staining (40×). (G) Well defined embryoid formation in a case of Grade 1 cervical intraepithelial neoplasia with hematoxylin and eosin staining (20×). (H and I) Macroscopic representation of an embryoid body assembled into a geometric hexagonal template platform in a case of gastric adenocarcinoma.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3278205&req=5

f2-cmar-4-009: Crystals generate embryoid bodies in the interior of the hexagonal geometry. (A) Detachment subimage of (B) image of embryoid body self-assembly into a geometric triangular chiral hexagonal-like crystal complex in a case of colon adenocarcinoma with hematoxylin and eosin staining (20×). (C) Detachment subimage of (D) image of embryoid body into hexagonal-like crystal complex in a case of lung squamous cell carcinoma with hematoxylin and eosin staining (20×). (E,F) Embryoid body self-assembly in a case of prostate adenocarcinoma with hematoxylin and eosin staining (40×). (G) Well defined embryoid formation in a case of Grade 1 cervical intraepithelial neoplasia with hematoxylin and eosin staining (20×). (H and I) Macroscopic representation of an embryoid body assembled into a geometric hexagonal template platform in a case of gastric adenocarcinoma.
Mentions: When the hexagon is assembled, the walls of the crystal structure trap molecules in their interior. In this closed environment, when the collision process stops, deceleration of the particles generates subcollisions and subejected crystal effect tails. It is at this particular moment that migration of crystals occurs in the interior of the hexagon embryoid bodies. It is conceivable from the biological point of view, that this process adds new amino acids to a chain reaction protein core with the creation of folding macromolecule adequate positional print identity (Figure 2A–I). The point at which electromagnetism and biology converges is when the appearance of these structures is detected.

Bottom Line: The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation.Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues.Reversal mechanisms in biology are intimately linked with DNA repair.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Hospital Departmental Villavicencio, Hospital Departmental Granada, Medicine School, University Cooperative of Colombia, Villavicencio, Meta, Colombia.

ABSTRACT
Cancer is, by definition, the uncontrolled growth of autonomous cells that eventually destroy adjacent tissues and generate architectural disorder. However, this concept cannot be totally true. In three well documented studies, we have demonstrated that cancer tissues produce order zones that evolve over time and generate embryoid body structures in a space-time interval. The authors decided to revise the macroscopic and microscopic material in well-developed malignant tumors in which embryoid bodies were identified to determine the phenotype characterization that serves as a guideline for easy recognition. The factors responsible for this morphogenesis are physical, bioelectric, and magnetic susceptibilities produced by crystals that act as molecular designers for the topographic gradients that guide the surrounding silhouette and establish tissue head-tail positional identities. The structures are located in amniotic-like cavities and show characteristic somite-like embryologic segmentation. Immunophenotypic study has demonstrated exclusion factor positional identity in relation to enolase-immunopositive expression of embryoid body and human chorionic gonadotropin immunopositivity exclusion factor expression in the surrounding tissues. The significance of these observations is that they can also be predicted by experimental image data collected by the Large Hadron Collider (LHC) accelerator at the European Organization for Nuclear Research, in which two-beam subatomic collision particles in the resulting debris show hyperorder domains similar to those identified by us in intercellular cancer collisions. Our findings suggest that we are dealing with true reverse biologic system information in an activated collective cancer stem cell memory, in which physics participates in the elaboration of geometric complexes and chiral biomolecules that serve to build bodies with embryoid print as it develops during gestation. Reversal mechanisms in biology are intimately linked with DNA repair. Further genotype studies must be carried out to determine whether the subproducts of these structures can be used in novel strategies to treat cancer.

No MeSH data available.


Related in: MedlinePlus