Axonal damage in the making: neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter.
Bottom Line: NfH-SMI35 was not correlated to any of the MR indices.The resulting change of proton mobility influences MTR and T1.This permits the in vivo detection of these subtle tissue changes on a proteomic level in patients with MS.
Affiliation: UCL Institute of Neurology, Department of Neuroinflammation, Queen Square, London WC1N 3BG, UK. email@example.comShow MeSH
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Mentions: Representative 1.5 T MR images of post mortem MS brain slice are shown in Figs. 2A–C. Fig. 2A shows the appearance of artefacts due to fixation of the brain slice on a cork board. These areas were not used for analyses. The quantitative data for the T1 relaxation time and MTR of the NLWM was summarised in Table 3. Significant correlations were detected between NfH SMI34 and T1 (R = 0.70, p = 0.01, Fig. 3A) and — inversely — with the MTR (R = − 0.73, p<0.01, Fig. 3B). No correlations were detected between MRI indices and any other of the measured brain proteins.
Affiliation: UCL Institute of Neurology, Department of Neuroinflammation, Queen Square, London WC1N 3BG, UK. firstname.lastname@example.org