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Severe organophosphate poisoning with delayed cholinergic crisis, intermediate syndrome and organophosphate induced delayed polyneuropathy on succession.

Azazh A - Ethiop J Health Sci (2011)

Bottom Line: Organophosphate compounds are the organic derivatives of Phosphorous containing acids and their effect on neuromuscular junction and Autonomic Synapses is clinically important.The patient reported here had severe Organophosphate Poisoning with various rare complications on a succession.This is the first report of Organophosphates Poisoning complicated by Intermediate Syndrome and Organophosphate Induced Delayed Polyneuropathy in Ethiopia and it is reported to increase awareness of health care workers on these rare complications of a common problem.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Medicine, Medical Faculty, Addis Ababa University.

ABSTRACT
Organophosphate compounds are the organic derivatives of Phosphorous containing acids and their effect on neuromuscular junction and Autonomic Synapses is clinically important. After exposure these agents cause acute and sub acute manifestations depending on the type and severity of the agents like Acute Cholinergic Manifestations, Intermediate Syndrome with Nicotinic features and Delayed Central Nervous System Complications. The patient reported here had severe Organophosphate Poisoning with various rare complications on a succession. This is the first report of Organophosphates Poisoning complicated by Intermediate Syndrome and Organophosphate Induced Delayed Polyneuropathy in Ethiopia and it is reported to increase awareness of health care workers on these rare complications of a common problem.

No MeSH data available.


Related in: MedlinePlus

Organophosphate compound (OPC), the top and neuromuscular junction (NMJ), the bottom.
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Figure 2: Organophosphate compound (OPC), the top and neuromuscular junction (NMJ), the bottom.

Mentions: Organophosphate compounds are the organic derivatives of Phosphorous containing acids and their effect on Neuromuscular Junction and Autonomic synapses is clinically important. In the Neuromuscular Junction Acetylcholine is released when a nerve impulse reaches terminal axonal end and it diffuses across the Synaptic Cleft and binds to Cholinergic Nicotinic receptors on the muscle fibers, causing them to contract. The enzyme, Cholinesterase splits Acetylcholine into Acetic Acid and Choline, thus stopping its action (Figure 1). The end products of the metabolism of Acetylcholine are taken up by nerve fibers and resynthesized into Acetylcholine. In Organophosphate poisoning the Cholinesterase are phosphorylated by the Phosphate end of Organophosphates; then the net result is accumulation of excessive Acetyl Chlorine with resultant effect on Muscarinic, Nicotinic and central nervous system (Figure 2).


Severe organophosphate poisoning with delayed cholinergic crisis, intermediate syndrome and organophosphate induced delayed polyneuropathy on succession.

Azazh A - Ethiop J Health Sci (2011)

Organophosphate compound (OPC), the top and neuromuscular junction (NMJ), the bottom.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3275864&req=5

Figure 2: Organophosphate compound (OPC), the top and neuromuscular junction (NMJ), the bottom.
Mentions: Organophosphate compounds are the organic derivatives of Phosphorous containing acids and their effect on Neuromuscular Junction and Autonomic synapses is clinically important. In the Neuromuscular Junction Acetylcholine is released when a nerve impulse reaches terminal axonal end and it diffuses across the Synaptic Cleft and binds to Cholinergic Nicotinic receptors on the muscle fibers, causing them to contract. The enzyme, Cholinesterase splits Acetylcholine into Acetic Acid and Choline, thus stopping its action (Figure 1). The end products of the metabolism of Acetylcholine are taken up by nerve fibers and resynthesized into Acetylcholine. In Organophosphate poisoning the Cholinesterase are phosphorylated by the Phosphate end of Organophosphates; then the net result is accumulation of excessive Acetyl Chlorine with resultant effect on Muscarinic, Nicotinic and central nervous system (Figure 2).

Bottom Line: Organophosphate compounds are the organic derivatives of Phosphorous containing acids and their effect on neuromuscular junction and Autonomic Synapses is clinically important.The patient reported here had severe Organophosphate Poisoning with various rare complications on a succession.This is the first report of Organophosphates Poisoning complicated by Intermediate Syndrome and Organophosphate Induced Delayed Polyneuropathy in Ethiopia and it is reported to increase awareness of health care workers on these rare complications of a common problem.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Medicine, Medical Faculty, Addis Ababa University.

ABSTRACT
Organophosphate compounds are the organic derivatives of Phosphorous containing acids and their effect on neuromuscular junction and Autonomic Synapses is clinically important. After exposure these agents cause acute and sub acute manifestations depending on the type and severity of the agents like Acute Cholinergic Manifestations, Intermediate Syndrome with Nicotinic features and Delayed Central Nervous System Complications. The patient reported here had severe Organophosphate Poisoning with various rare complications on a succession. This is the first report of Organophosphates Poisoning complicated by Intermediate Syndrome and Organophosphate Induced Delayed Polyneuropathy in Ethiopia and it is reported to increase awareness of health care workers on these rare complications of a common problem.

No MeSH data available.


Related in: MedlinePlus