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Disposable screen-printed sensors for determination of duloxetine hydrochloride.

Alarfaj NA, Ammar RA, El-Tohamy MF - Chem Cent J (2012)

Bottom Line: Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers.The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms.Results of the analysis were validated statistically by recovery studies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, College of Science, King Saud University, P,O, Box 22452, Riyadh 11495, Saudi Arabia. star2000star@gmail.com.

ABSTRACT
A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

No MeSH data available.


Potentiometric titration of DL with phosphomolybdic acid 5.0 × 10-3 mol L-1 using SPCEs fabricated with different modes SPCE, PVC and CPEs (1.0 mL of 1.0 × 10-2 mol L-1 DL).
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Figure 4: Potentiometric titration of DL with phosphomolybdic acid 5.0 × 10-3 mol L-1 using SPCEs fabricated with different modes SPCE, PVC and CPEs (1.0 mL of 1.0 × 10-2 mol L-1 DL).

Mentions: In addition to the application of SPCEs in direct potentiometric determination of DL hydrochloride, the developed sensors were also used as end-point indicator electrodes in the potentiometric titration of DL hydrochloride with phosphomolybdic acid. The effect of electrode plasticizer on the titration performance was also investigated. Generally, the printed electrodes plasticized with DOP gave the highest total potential change (ΔE = 380 mV) compared with those plasticized with DBS, DOS and DBP (ΔE = 180, 148 and 90 mV for the plasticizers in the same order). Moreover, plain SPCEs showed the best titration curve (Figure 3) comparable to those modified with either the DL-PMA or ion-pairing agent. Under the same conditions, SPCEs showed a better titration curve than that obtained with CPEs and similar to PVC electrode (Figure 4). The titration curves were symmetrical with very well-defined inflexion points of potential jumps indicating the high sensitivity of the electrode. The titration process was highly reproducible with average recoveries 99.6 ± 0.8 and 99.6 ± 0.6% for 1.0 × 10-2 and 1.0 × 10-3 mol L-1 DL, respectively. It was found that the same electrode was successfully applied for more than 20 titration processes over 20 days with non-significant drift in the total potential change (ΔE = 286 ± 1 mV) and average recovery of 99.98 ± 0.8%.


Disposable screen-printed sensors for determination of duloxetine hydrochloride.

Alarfaj NA, Ammar RA, El-Tohamy MF - Chem Cent J (2012)

Potentiometric titration of DL with phosphomolybdic acid 5.0 × 10-3 mol L-1 using SPCEs fabricated with different modes SPCE, PVC and CPEs (1.0 mL of 1.0 × 10-2 mol L-1 DL).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3275491&req=5

Figure 4: Potentiometric titration of DL with phosphomolybdic acid 5.0 × 10-3 mol L-1 using SPCEs fabricated with different modes SPCE, PVC and CPEs (1.0 mL of 1.0 × 10-2 mol L-1 DL).
Mentions: In addition to the application of SPCEs in direct potentiometric determination of DL hydrochloride, the developed sensors were also used as end-point indicator electrodes in the potentiometric titration of DL hydrochloride with phosphomolybdic acid. The effect of electrode plasticizer on the titration performance was also investigated. Generally, the printed electrodes plasticized with DOP gave the highest total potential change (ΔE = 380 mV) compared with those plasticized with DBS, DOS and DBP (ΔE = 180, 148 and 90 mV for the plasticizers in the same order). Moreover, plain SPCEs showed the best titration curve (Figure 3) comparable to those modified with either the DL-PMA or ion-pairing agent. Under the same conditions, SPCEs showed a better titration curve than that obtained with CPEs and similar to PVC electrode (Figure 4). The titration curves were symmetrical with very well-defined inflexion points of potential jumps indicating the high sensitivity of the electrode. The titration process was highly reproducible with average recoveries 99.6 ± 0.8 and 99.6 ± 0.6% for 1.0 × 10-2 and 1.0 × 10-3 mol L-1 DL, respectively. It was found that the same electrode was successfully applied for more than 20 titration processes over 20 days with non-significant drift in the total potential change (ΔE = 286 ± 1 mV) and average recovery of 99.98 ± 0.8%.

Bottom Line: Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers.The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms.Results of the analysis were validated statistically by recovery studies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, College of Science, King Saud University, P,O, Box 22452, Riyadh 11495, Saudi Arabia. star2000star@gmail.com.

ABSTRACT
A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

No MeSH data available.