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Disposable screen-printed sensors for determination of duloxetine hydrochloride.

Alarfaj NA, Ammar RA, El-Tohamy MF - Chem Cent J (2012)

Bottom Line: Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers.The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms.Results of the analysis were validated statistically by recovery studies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, College of Science, King Saud University, P,O, Box 22452, Riyadh 11495, Saudi Arabia. star2000star@gmail.com.

ABSTRACT
A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

No MeSH data available.


Scanning electron micrographs of electrode surface. a) Carbon ink containing DOP, b) Carbon ink without DOP.
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Figure 1: Scanning electron micrographs of electrode surface. a) Carbon ink containing DOP, b) Carbon ink without DOP.

Mentions: SPCEs are heterogeneous carbon electrodes having a composite structure since the printing ink matrix colligates different phases (carbon powder, plasticizer and polymeric binder which is PVC dissolved in a proper organic solvent). After printing and curing, carbon tracks were deposited on the substrate with a final composition of 34.6% plasticizer, 57.7% carbon and 7.7% polymeric binder. This composition combines those of both carbon pastes (28.6% plasticizer and 71.4% carbon) and PVC membranes (50% plasticizer, and 50% PVC). Scanning electron microscopy (SEM) indicated that addition of the plasticizer into the printing carbon ink produced a semi-liquid phase with smooth electrode surface (Figure 1). Such unique composition makes the SPCEs to combine the electroanalytical behavior of both PVC and CPE.


Disposable screen-printed sensors for determination of duloxetine hydrochloride.

Alarfaj NA, Ammar RA, El-Tohamy MF - Chem Cent J (2012)

Scanning electron micrographs of electrode surface. a) Carbon ink containing DOP, b) Carbon ink without DOP.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3275491&req=5

Figure 1: Scanning electron micrographs of electrode surface. a) Carbon ink containing DOP, b) Carbon ink without DOP.
Mentions: SPCEs are heterogeneous carbon electrodes having a composite structure since the printing ink matrix colligates different phases (carbon powder, plasticizer and polymeric binder which is PVC dissolved in a proper organic solvent). After printing and curing, carbon tracks were deposited on the substrate with a final composition of 34.6% plasticizer, 57.7% carbon and 7.7% polymeric binder. This composition combines those of both carbon pastes (28.6% plasticizer and 71.4% carbon) and PVC membranes (50% plasticizer, and 50% PVC). Scanning electron microscopy (SEM) indicated that addition of the plasticizer into the printing carbon ink produced a semi-liquid phase with smooth electrode surface (Figure 1). Such unique composition makes the SPCEs to combine the electroanalytical behavior of both PVC and CPE.

Bottom Line: Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers.The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms.Results of the analysis were validated statistically by recovery studies.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, College of Science, King Saud University, P,O, Box 22452, Riyadh 11495, Saudi Arabia. star2000star@gmail.com.

ABSTRACT
A screen-printed disposable electrode system for the determination of duloxetine hydrochloride (DL) was developed using screen-printing technology. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrodes was used as duloxetine hydrochloride sensor. The proposed sensors worked satisfactorily in the concentration range from 1.0 × 10-6-1.0 × 10-2 mol L-1 with detection limit reaching 5.0 × 10-7 mol L-1 and adequate shelf life of 6 months. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically by recovery studies.

No MeSH data available.